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The Role of Endotoxins in Methscopolamine Induced Ruminal Stasis in Calves

Betydelse av endotoxiner?

Acta Veterinaria Scandinavica volume 33, pages 129–138 (1992)Cite this article

Abstract

Methscopolamine was used to induce ruminal stasis in calves. Clinical and blood biochemical parameters were studied to judge the possible role of gastro-intestinal endotoxins from Gram-negative bacteria. Two trials were carried out where one injection of 100 mg and 3 consecutive injections of 70 mg of methscopolamine were administered. The animals showed signs of ruminal stasis. General clinical signs and changes in blood biochemical parameters were similar to what is found in endotoxaemia or in induced ruminal acidosis. Relevant parameters such as prostaglandin F2α metabolite, endotoxin, iron, zinc, calcium and glutamate dehydrogenase changed significantly indicating exposure of endotoxins.

Sammanfattning

II. Vid metylskopolamininducerad våmstas hos kalv. Metylskopolamin användes för att inducera våmstas hos kalv. Kliniska och blodkemiska parametrar studerades för att utvärdera möjligheten av resorption av endotoxiner från Gram-negativa bakterier i mag-tarmkanalen. Två försöksserier utfördes med metylskopolamin: 100 mg gavs som engångsdos respektive 3 upprepade injektioner med 70 mg. Djuren visade tydliga tecken på våmstas. Den kliniska bilden och förändringar i blodkemiska parametrar är likartade dem som syns vid endotoxinämi eller vid inducerad våmacidos. Viktiga parametrar som prostaglandin F2 α metabolit, endotoxin, järn, zink, kalcium och glutamatdehydrogenas förändrades signifikant, vilket indikerar att djuren exponerats för endotoxiner.

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Authors and Affiliations

  1. Department of Obstetrics and Gynaecology and Department of Clinical Chemistry, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Box 7039, S-750 07, Uppsala, Sweden

    S. Aiumlamai & H. Kindahl

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  1. S. Aiumlamai
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  2. H. Kindahl
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Aiumlamai, S., Kindahl, H. The Role of Endotoxins in Methscopolamine Induced Ruminal Stasis in Calves. Acta Vet Scand 33, 129–138 (1992). https://doi.org/10.1186/BF03547319

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Acta Veterinaria Scandinavica

ISSN: 1751-0147