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Early Foetal Death in the Mare

Histological, Bacteriological and Cytological Findings in the Endometrium

Tidig fosterdöd hos sto: Histologiska, bakteriologiska och cytologiska observationer i endometriet. Femton ston, vilka tidigare resorberat eller aborterat ett flertai gånger, intensivstuderades före betäckning/insemination samt till och med 5 månaders dräktighet. Alla de 15 stona blev dräktiga under försöksperioden; 10 ston hade normal dräktighet under det första försöksåret. Fem ston resor-berade/aborterade 1 eller 2 gånger följt av en dräktighet vilken resulterade i levande fött föl

Acta Veterinaria Scandinavica volume 33, pages 147–160 (1992)Cite this article

Abstract

Fifteen mares which had each lost their pregnancies 2 to 8 times during the preceding 6 years were used in a study comprising 1 or 2 breeding seasons for each mare. During the research period all 15 mares conceived and 10 of the mares had normal pregnancies in the 1st experimental year. Five mares resorbed/aborted once or twice during the 1st year. This was followed by a pregnancy that terminated in a live foal.

Histopathological examinations of uterine biopsies showed a wide range of histopathological conditions, from absence of changes excessive for the mare’s age and parity to the most severe changes of the endometrium. Most likely, endometritis, acute as well as chronic degenerative endometritis, is the most common cause of early foetal death in the mare.

Good breeding management is essential and was often enough to make the mares produce a foal. Additional treatment was needed in some of the mares and was based on the course of the conceptus loss and the condition of the endometrium, as determined by clinical, histological, bacteriological and cytological examinations.

Sammanfattning

Vid histopatologisk undersökning av endometriet återfanns hela skalan från en normal slemhinna till mycket kraftiga förändringar. Endometrit, akut såväl som kronisk degenerativ, utgör med stör sannolikhet en av de viktigaste orsakerna tili tidig fosterdöd hos sto.

Skötselfaktorer är av stor vikt för att undvika tidig fosterdöd. God skötsel innebär att stona hålls i god näringsbalans, betäcks få gånger nära ägglossning under den sexuella säsongen, att man söker undvika stressfaktorer, att akut endometrit diagnostice-ras och behandlas före betäckning samt att preventiva åtgärder vidtages mot förnyad endometrit hos infektionskänsliga ston.

References

  • Adams GP, Kastelic JP, Bergfeldt DR, Ginther OJ: Effect of uterine inflammation and ultrasonically-detected uterine pathology on fertility in the mare. J. Reprod. Fertil. 1987, Suppl. 35, 445–487.

    CAS  Google Scholar 

  • Andrews RV: Influence of the adrenal gland on gonadal function. Adv. Sex. Horm. Res. 1976,3, 197–215.

  • Asa CS, Ginther OJ: Glucocorticoid suppression of oestrus, follicles, LH and ovulation in the mare. J. Reprod. Fertil. 1982, Suppl. 32, 247–251.

  • Asbury AC: Failure of uterine defense mechanisms. In: Robinson NE (ed): Current Therapy in Equine Medicine. W.B. Saunders Company, Philadelphia, USA, 2, 1987, p. 508–511.

  • Bane A: Veterinary medical considerations on the cervix as fertility factor. Acta Obst. et Gynec. scand. 1959, 38, Suppl. 1, 59–68.

  • de la Concha-Bermejillo A, Kennedy PC: Prognostic value of endometrial biopsy in the mare: A retrospective analysis. J. Amer. vet. med. Ass. 1982, 181, 680–681.

    PubMed  Google Scholar 

  • la Cour A, Sprinkle TA Jr: Relationship of endometrial cytology and fertility in the broodmare. Equine Pract. 1985, 7, 27–36.

    Google Scholar 

  • Darenius K, Kindahl H, Madej A: Clinical and endocrine studies in mares with known history of repeated conceptus losses. Theriogenology 1988, 29, 1215–1232.

    Article  Google Scholar 

  • Darenius K, Fredriksson G, Kindahl H: Allyl trenbolone and flunixin meglumine treatment of mares with repeated embryonic loss. Equine vet. J. 1989, Suppl. 8, 35–39.

  • Darenius K, Einarsson S, Kindahl H: Endocrine studies of early pregnancy loss in the mare; comparison within mare between pregnancy loss and consecutive pregnancy. Submitted for publication. 1992.

  • Doig PA, McKnight JD, Miller RB: The use of endometrial biopsy in the infertile mare. Can. vet. J. 1981, 22, 72–76.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Gadd JD: The relationship of bacterial cultures, microscopic smear examination and medical treatment to surgical correction of barren mares. Proc. 21st Ann. Conv. Amer. Ass. equine Pract. 1975, 362–368.

  • Gadd JD, Schirmer HKA: Correlation between vaginal pathogens and the intestinal bacterial flora in the mare with vaginitis. Proc. 14th Ann. Conv. Amer. Ass. equine Pract. 1968, 105–113.

  • Kenney RM: Clinical aspects of endometrial biopsy in fertility evaluation of the mare. Proc. 23rd Ann. Conv. Amer. Ass. equine Pract. 1977, 105–122.

  • Kenney RM: Cyclic and pathologic changes of the mare endometrium as detected by biopsy, with a note on early embryonic death. J. Amer. vet. med. Ass. 1978, 172, 241–262.

    CAS  PubMed  Google Scholar 

  • Kenney RM, Bergman RV, Cooper WL, Morse GW: Minimal contamination techniques for breeding mares: Technique and preliminary findings. Proc. 21st Ann. Conv. Amer. Ass. equine Pract. 1975, 327–336.

  • Leishman D, Miller RB, Doig PA: A quantitative study of the histological morphology of the endometrium of normal and barren mares. Can. J. comp. Med. 1982, 46, 17–20.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Neely DP, Liu IK, Hillman RB: Evaluation and therapy of genital diseases in the mare. In: JP Hughes (ed): Equine Reproduction, Veterinary Learning Systems Co., Inc., Publishers Hoffman-La Roche Inc., New Jersey, USA, 1983, p. 40–56.

  • Ricketts SW: Endometrial biopsy as a guide to diagnosis and endometrial pathology in the mare. J. Reprod. Fertil. 1975, Suppl. 23, 341–345.

  • Ricketts SW: Histological and histopathological studies of the endometrium of the mare. Thesis, The Royal College of Veterinary Surgeons, London, UK. 1978.

  • Ricketts SW: Uterine abnormalities. In: NE Robinson (ed): Current Therapy in Equine Medicine. W.B. Saunders Co., Philadelphia, USA, 2, 1987, p. 503–508.

  • Ricketts SW: Genital abnormalities and the barren mare. Proc. British Equine Vet. Ass., Equine Stud Medicine Course, Newmarket, UK 1988, 140–159.

  • Ricketts SW, Mackintosh ME: (1987) Role of anaerobic bacteria in equine endometritis. J. Reprod. Fertil. 1987, Suppl. 35, 343–351.

  • Shideler RK, McChesney AE, Voss JL, Squires EL: Relationship of endometrial biopsy and other management factors on fertility of broodmares. J. Eq. Vet. Sci.. 1982 2, 5–10.

    Article  Google Scholar 

  • Torp M: Histological studies of the uterus of mares with pregnancy loss. Norsk Vet. Tidsskr. 1989, 101, 5–13.

    Google Scholar 

  • Whitwell K: Investigations into fetal and neonatal losses in the horse. Vet. Clin. North Amer. Large Animal Practice 1980, 2, 313–331.

    Article  CAS  Google Scholar 

  • Woods GL, Baker CB, Baldwin JL, Ball BA, Bilinski J, Cooper WL, Ley WB, Mank EC, Erb HN: Early pregnancy loss in brood mares. J. Reprod. Fertil. 1987, Suppl. 35, 455–459.

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  1. Department of Obstetrics and Gynaecology, Swedish University of Agricultural Sciences, S-750 07, Uppsala, Sweden

    K. Darenius

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Darenius, K. Early Foetal Death in the Mare. Acta Vet Scand 33, 147–160 (1992). https://doi.org/10.1186/BF03547321

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Acta Veterinaria Scandinavica

ISSN: 1751-0147