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Secretion of Radioiodine in Milk Following a Single Oral Administration in the Cow

Die Ausscheidung von Radiojod in der Milch nach einmaliger Gabe per os bei Kuh

Utsöndring av radiojod i mjölk efter per oral engångsgiva åt ko

Summary

The secretion of radioiodine in the milk following the administration of a single oral dose was studied using I131. All of the values are corrected for the physical decay of the isotope.

I131 began to appear in the milk 30 minutes after administration with a maximal concentration of, on the average, 1.7 per cent of the given dose per 1 of milk at about six hours following administration. The subsequent reduction in the concentration showed a two exponential course with biological half-lives of 0.6 days and 10 days, respectively. The total secretion in the milk was between 10 and 27 per cent of the given dose of I131 in six days. The total secretion of radioiodine in the milk was seen to be dependent upon the cow’s milk production.

Zusammenfassung

Die Ausscheidung von Radiojod in der Milch nach einmaliger Gabe per os bei Kuh wurde mit J131 studiert. Sämtliche Werte wurden för den physikalischen Zerfall des Isotopes korrigiert.

J131 begann 30 Minuten nach der Eingabe in der Milch aufzutreten und hatte eine maximale Konzentration, mit einem Mittelwert von 1,7 Prozent der gegebenen Dosis per Liter Milch, sechs Stunden nach der Eingabe. Die darauffolgende Konzentrationsabnahme zeigte einen zweiexponentiellen Verlauf mit den biologischen Halbierungszeiten von 0,6 Tagen bezw. 10 Tagen. Totalt wurde zwischen 10 Prozent und 27 Prozent der gegebenen Menge J131 mit der Milch unter sechs Tagen ausgeschieden. Die Gesamtausscheidung von Radiojod in der Milch schien von der Milchproduktion der Kuh abhängig zu sein.

Sammanfattning

Utsöndringen av radiojod i mjölken efter per oral engångsgiva åt ko har studerats med J131. Samtliga värden har korrigerats för isotopens fysikaliska sönderfall.

J131 började uppträda i mjölken 30 minuter efter ingivningen och med en maximal koncentration av i medeltal 1,7 procent av given dos per liter mjölk omkring sex timmar efter ingivningen. Den efterföljande koncentrationsminskningen visade ett tvåexponentiellt förlopp med biologiska halveringstider på 0,6 dygn respektive 10 dygn. Totalt utsöndrades med mjölken mellan 10 procent och 27 procent av given mängd I131 på sex dygn. Totalutsöndringen av radiojod i mjölken syntes vara beroende av kons mjölkproduktion.

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The investigation was aided by grants from the Research Institute of National Defence, Swedish Agriculture Research Council, and the Swedish Atomic Research Council.

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Thorell, C.B. Secretion of Radioiodine in Milk Following a Single Oral Administration in the Cow. Acta Vet Scand 5, 217–223 (1964). https://doi.org/10.1186/BF03547376

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