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Megakaryocytes, Thrombocytes, and Blood-Clotting Time in Dogs With Experimental Hepatitis Contagiosa Canis
Megakaryozyten, Thrombozyten und Blutgerinnungszeit bei Hunden mit experimenteller Hepatitis contagiosa canis
Megakaryocyter, trombocyter och blodkoagulationstid hos hundar med experimentell Hepatitis contagiosa canis
Acta Veterinaria Scandinavica volume 5, pages 370–383 (1964)
Summary
This paper reports a study of total thrombocyte counts, prothrombin index, clotting-times, and qualitative and quantitative determinations of the megakaryocytes in dogs with experimentally produced Hepatitis contagiosa canis. The megakaryocytes were studied in rib-marrow sections. A marked decrease was noted in the total number of thrombocytes down to less than 20,000 platelets per mm3 within 4–7 days of the inoculation. The prothrombin index changed very little. The haemorrhagic tendency in Hepatitis contagiosa canis is considered to be due to the thrombocytopenia in combination with vascular damage. A decrease in the number of megakaryocytes and qualitative changes in these cells were demonstrated. A prolongation of the clotting-time was established and its causes are discussed.
Zusammenfassung
An Hunden mit experimenteller H.c.c. wurden die Veränderungen in der Gesamtanzahl der Thrombozyten, des Protrombinindexes, der Blutgerinnungszeit als auch die qualitativen und quantitativen Veränderungen im Megakaryozytenbild untersucht. Das letztgenannte wurde durch Biopsie der Rippen untersucht. Eine ausgeprägte Senkung der gesamten Thrombozyten bis zu Werten oft unter 20.000 Thombozyten/mm3 4–7 Tage nach der Inokulation, wurde festgestellt. Der Protrombinindex wurde kaum verändert. Es wird angenommen, dass die Neigung zu Blutungen bei der H.c.c. von der Thrombozytopenie samt Blutgefässschädigungen abhängig ist. Die Verminderung der Zahl der Megakaryozyten als auch die bei ihnen festgestellte qualitative Veränderungen werden angegeben. Einer Verlängerung der Blutgerinnungszeit wurde festgestellt und ihre Ursachen besprochen.
Sammanfattning
På hundar med experimenteilt framkallad H.c.c. har förändringar av totalantalet trombocyter, protrombinindex, blodkoagulationstider samt kvalitativa och kvantitativa förändringar i megakaryocytbilden följts. De senare har studerats på snitt från rebensbiopsier. En markant nedgång av totalantalet trombocyter till värden ofta understigande 20.000 trombocyter/mm3 4–7 dagar efter inokulationen har konstateras. Protrombinindex förändras lindrigt. Blödningsbenägenheten vid H.c.c. anses bero på trombocytopenin i kombination med kärlskada. Minskning av antalet megakaryocyter samt hos dem iakttagbara kvalitativa förändringar redovisas. En förlängning av blodets koagulationstid har konstaterats och dess orsaker diskuteras.
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Supported by grants from “Anslag för främjande av medicinsk forskning vid Veterinärhögskolan”.
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Lindblad, G., Bäckgren, A.W. Megakaryocytes, Thrombocytes, and Blood-Clotting Time in Dogs With Experimental Hepatitis Contagiosa Canis. Acta Vet Scand 5, 370–383 (1964). https://doi.org/10.1186/BF03547390
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DOI: https://doi.org/10.1186/BF03547390