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Electrocardiographic Examinations in Dogs With Experimental Hepatitis Contagiosa Canis

(Elektrokardiographische) EKG-Untersuchungen an Hunden mit experimenteller Hepatitis contagiosa canis.

EKG-undersökningar på hundar med experimentell Hepatitis contagiosa canis.

Summary

Dogs with experimentally produced Hepatitis contagiosa canis were subjected to repeated electrocardiographic examinations during the course of the disease. Varying degrees of depression of the STJ and S-T segments and deviations of the T-wave were noted. Serum-electrolyte studies made during the illness showed a decrease of potassium, sodium, and chlorides which did not seem to be the cause of the observed electrocardiographic abnormalities. Circulatory disturbances and changes in the endothelial cells described elsewhere are considered to be the cause of a disturbance in the metabolism and the function of the myocardium with resulting depression of the STJ and S-T segments and deviations of the T-wave.

Zusammenfassung

Hunde mit experimentell hervorgerufener H.c.c, wurden während des Krankheitsverlaufes wiederholt elektrokardiographisch untersucht. Man hat verschieden starke Senkungen vom STJ und S-T-Segment als auch Veränderungen der T-Welle beobachtet. Die gleichzeitig vorgenommenen Untersuchungen der Serumelektrolyte zeigen K-, Na- und Cl- Senkungen, die jedoch nicht als Ursache der beobachteten EKG-Veränderungen aufgefasst werden. Die in anderen Arbeiten beschiebenen Kreislaufstörungen und die Schädigungen des Endothels, werden als Ursache des veränderten Stoffwechsels und von Funktionsstörungen im Myokard mit Senkung des STJ und S-T- Segments und T-Wellen-deviation aufgefasst.

Sammanfattning

På hundar med experimentellt framkallad H.c.c. har under sjukdomsutvecklingen upprepade EKG-undersökningar företagits. Varierande grad av sänkninger av STJ och S-T segment och förändringar av T-vågen har konstaterats. Parallellt företagna serumelektrolytundersökningar visar K-, Na- och Cl- sänkningar, vilka dock icke synes vara orsak till de konstaterade EKG-förändringarna. I andra arbeten beskrivna cirkulationsrubbningar och endotelcellskador, anses vara orsak till ändrad metabolism och funktionsstörning i myokardiet med sänkning av STJ och S-T segment och T-vågsdeviationer som följd.

References

  1. Bellet, S.: The electrocardiogram in electrolyte imbalance. Arch. Intern. Med. 1955, 96, 618–638.

    CAS  Article  Google Scholar 

  2. Bland, J. H.: Disturbances of fluid balance. 2nd Ed. W. B. Saunders & Co. Philadelphia & London 1956.

  3. Brun, C.: Klorbestemmelse. En mikrometode. Nord. Med. 1949, 42, 1774–1776.

    CAS  Google Scholar 

  4. Espmarck, J. Å. & Salenstedt, C. R.: Haemagglutination-inhibition test for titration of antibodies against Hepatitis contagiosa canis (Infectious Canine Hepatitis). Arch. ges. Virusforsch. 1961, 11, 64–72.

    Article  Google Scholar 

  5. Goldberger, E.: Unipolar lead electrocardiography and vectorcardiography. 3rd Ed. Lea & Febiger. Philadelphia 1954.

  6. Goldman, M. J.: Principles of clinical electrocardiography. Lange Medical Publication, Los Altos California 1956.

  7. Lannek, N.: A clinical and experimental study on the electrocardiogram in dogs. Ivar Häggströms Boktryckeri AB Stockholm 1949.

  8. Lindblad, G., Brånemark, P. I. & Lindström, J.: Capillary form and function in dogs with experimental Hepatitis contagiosa canis. An intravital microvascular study. Acta vet. scand. 1964, 5, 384–393.

    Google Scholar 

  9. Lindblad, G. & Björkman, N.: Ultrastructural alterations in sinusoidal endothelium of liver and bone marrow in dogs with experimental Hepatitis contagiosa canis. Acta path, microbiol. scand. In press.

  10. Lindblad, G. & Persson, F.: Transaminase and transferase activities in blood plasma of dogs with experimentally produced Hepatitis contagiosa canis (H.c.c). Acta vet. scand. 1962, 3, 378–390.

    CAS  Article  Google Scholar 

  11. Persson, F., Persson, S. & Sibalin, M.: The aetiological role of Hepatitis contagiosa canis (H.c.c.) in chronic nephritis in dogs. Acta vet. scand. 1961, 2, 137–151.

    Article  Google Scholar 

  12. Rubarth, S.: An acute virus disease with liver lesions in dogs. (Hepatitis contagiosa canis). Acta path. microbiol. scand. Suppl. 69, 1947.

  13. Schaefer, H., Das Elektrokardiogram. Theorie und Klinik. Springer Verlag, Berlin, Göttingen und Heidelberg. 1951.

  14. Taussky, H. H. & Shorr, E.: A microcolorimetric method for the determination of inorganic phosphorus. J. Biol. Chem. 1953, 202, 675–685.

    CAS  Article  Google Scholar 

  15. Thalme, B.: A system of microliter methods suitable for routine clinical work. Acta med. scand. 1963. Suppl. 174.

  16. Thorén, L.: Vätskebalans. Almqvist & Wickseils Boktryckeri AB, Uppsala, 1960.

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Supported by grants from “Anslag för främjande av medicinsk forskning vid Veterinärhögskolan”.

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Lindblad, G. Electrocardiographic Examinations in Dogs With Experimental Hepatitis Contagiosa Canis. Acta Vet Scand 5, 394–403 (1964). https://doi.org/10.1186/BF03547392

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