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The in Vitro Effects of Peptide-Precipitating Lignosulphonic Acids on Various Biologically Active Substances Produced by or with Action on Microorganisms

In vitro virkninger av peptidpresipiterende ligninsulfonsyrer på forskjellige biologisk aktive stoffer, produsert av eller med virkning på mikroorganismer

Acta Veterinaria Scandinavica volume 14, pages 129–146 (1973)Cite this article

Abstract

The effects of lignosulphonic acids on colicins, coliphages, different antibiotics, ß-toxin of Staphylococcus aureus, lecithinases of Clostridium perfringens and of Bacillus cereus, hemolysins of Bacillus cereus and Escherichia coli, the bactericidal effect of lysolecithin and on specific and naturally occurring serum proteinase inhibitors have been studied. It was found that lignosulphonic acids distinctly inhibit the biological activities tested, with the possible exceptions of the inhibitory effects of serum antiproteinases, naturally occurring inhibitors in serum, and the bacteriolytic effect of coliphages. The inhibiting effects are discussed in relation to the use of animal fodder containing lignosulphonic acids, and to the appearance of a selected microbial flora in sulphite spent liquor recipients.

Sammendrag

En har studert virkninger av ligninsulfonsyrer på coliciner, colifager, forskjeilige antibiotika, ß-toksin fra Staphylococcus aureus, lecitinaser fra Clostridium perfringens og Bacillus cereus, hemolysiner fra Bacillus cereus og Escherichia coli, på den baktericide effekt av lysolecithin, og på spesifikke og naturlige forekommende antiproteinaser i serum. Det ble vist, at ligninsulfonsyrer har hemmende virkning på de undersøkte biologiske aktiviteter, muligens unntatt effekten av antiproteinaser, naturlig forekommende inhibitorer i serum og på den bakteriolytiske effekt av colifager.

Den hemmende virkning har en diskutert i relasjon til bruken av fórstoffer som inneholder ligninsulfonsyrer og i forhold til den selekterte mikrobielle flora en finner i resipienter for sulfittlut.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Veterinary College of Norway, Oslo Dep., Postbox 8146, Oslo 1, Norway

    Bjørn Næss & Olav Sandvik

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  1. Bjørn Næss
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  2. Olav Sandvik
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Næss, B., Sandvik, O. The in Vitro Effects of Peptide-Precipitating Lignosulphonic Acids on Various Biologically Active Substances Produced by or with Action on Microorganisms. Acta Vet Scand 14, 129–146 (1973). https://doi.org/10.1186/BF03547416

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Acta Veterinaria Scandinavica

ISSN: 1751-0147