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Proteases of Clostridium Botulinum

I. Classification of Proteases and Literature Survey

Clostridium botulinum proteases

I. Klassifisering av proteaser og litteraturoversigt

Abstract

Proteolytic activity has long been regarded as an important characteristic for distinguishing between different types of Clostridium botulinum. While all strains of Clostridium botulinum type A examined so far possess proteolytic activity, the types B and F have both proteolytic and non-proteolytic varieties. Clostridium botulinum types C, D and E were generally regarded as non-proteolytic, but different investigators have shown proteolytic activity in certain strains of these types. A summary of the classification of proteolytic enzymes in general is given and further, investigations are reviewed on the proteolytic activity in Clostridium botulinum.

Sammendrag

Proteolytisk aktivitet betraktes som et viktig taksonomisk kriterium for Clostridium botulinum. Alle undersøkte Clostridium botulinum type A-stammer har proteolytisk aktivitet, mens Clostridium botulinum type B og F har både proteolytiske og ikke-proteolytiske stammer. Clostridium botulinum type C og D ble tidligere betraktet som ikke proteolytiske, men senere undersøkeiser har vist at svakt toksiske stammer har proteolytisk aktivitet. Det er delte meninger om hvorvidt Clostridium botulinum type E-stammer har proteolytisk aktivitet. I denne artikkel gis en kort oversikt om klassifisering av proteolytiske enzymer og videre en oversikt over utførte undersøkeiser av proteolytisk aktivitet hos forskjellige Clostridium botulinum stammer.

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Proteolytic enzyme or protease are the terms used throughout this study. However, in this particular article the terms used by the respective investigators are applied.

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Tjaberg, T.B. Proteases of Clostridium Botulinum. Acta Vet Scand 14, 184–192 (1973). https://doi.org/10.1186/BF03547421

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