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Proteases of Clostridium Botulinum
I. Classification of Proteases and Literature Survey
Clostridium botulinum proteases
I. Klassifisering av proteaser og litteraturoversigt
Acta Veterinaria Scandinavica volume 14, pages 184–192 (1973)
Abstract
Proteolytic activity has long been regarded as an important characteristic for distinguishing between different types of Clostridium botulinum. While all strains of Clostridium botulinum type A examined so far possess proteolytic activity, the types B and F have both proteolytic and non-proteolytic varieties. Clostridium botulinum types C, D and E were generally regarded as non-proteolytic, but different investigators have shown proteolytic activity in certain strains of these types. A summary of the classification of proteolytic enzymes in general is given and further, investigations are reviewed on the proteolytic activity in Clostridium botulinum.
Sammendrag
Proteolytisk aktivitet betraktes som et viktig taksonomisk kriterium for Clostridium botulinum. Alle undersøkte Clostridium botulinum type A-stammer har proteolytisk aktivitet, mens Clostridium botulinum type B og F har både proteolytiske og ikke-proteolytiske stammer. Clostridium botulinum type C og D ble tidligere betraktet som ikke proteolytiske, men senere undersøkeiser har vist at svakt toksiske stammer har proteolytisk aktivitet. Det er delte meninger om hvorvidt Clostridium botulinum type E-stammer har proteolytisk aktivitet. I denne artikkel gis en kort oversikt om klassifisering av proteolytiske enzymer og videre en oversikt over utførte undersøkeiser av proteolytisk aktivitet hos forskjellige Clostridium botulinum stammer.
References
Ashmarin, I. P. & I. V. Vorentsov: Some properties of highly purified proteinase from Clostridium botulinum type B. Biokhimiya 1963, 28, 816–823.
Bergman, Max A.: Classification of proteolytic enzymes. Adv. Enzymol. 1942, 2, 49–68.
Bergman, Max A. & J. S. Fruton: The specificity of proteinases. Adv. Enzymol. 1941, 1, 63–98.
DasGupta, B. R. & H. Sugiyama: Isolation and characterization of a protease from Clostridium botulinum type B. Biochim. biophys. Acta (Amst.) 1972, 268, 719–729.
Division of Microbiology, Bureau of Science, FDA: Serological studies of Clostridium botulinum. Report of the Spring 1969 Technical Meeting of the Interagency, Botulism Research Coordinating Committee (IBRCC) 1969.
Elberg, S. S. & K. F. Meyer: The extracellular proteolytic system of Clostridium parabotulinum. J. Bact. 1939, 37, 541–564.
Grassmann, W. & F. Schneider: Proteasen. (Proteases). Ergebn. Enzymforsch. 1936, 5, 79–116.
Hagihara, B.: Bacterial and Mould Proteases. In The Enzymes. 2nd Ed. Vol. IV, p. 193. Acad. Press, New York 1960.
Hartley, B. S.: Proteolytic enzymes. Ann. Rev. Biochem. 1960, 29, 45–72.
Hausken, O. W.: Serological studies on proteolytic enzymes of genus Clostridium. Acta path, microbiol. scand. 1967, 71, 387–392.
Kodama, H.: Studies on the proteolytic enzyme of Clostridium botulinum. Jap. J. vet. Res. 1961, 9, 127–128.
Lee, W. H. & H. Riemann: Correlation of toxic and non-toxic strains of Clostridium botulinum by DNA-composition and homology. J. gen. Microbiol. 1970, 60, 117–123.
Maschmann (1937, 1938). cit. Marjorie Stephenson: Bacterial Metabolism. 3rd Ed. p. 111, Longmans, Green & Co., London 1949.
Maschmann, E.: Bakterien-Proteasen. (Proteases from bacteria). Ergebn. Enzymforsch. 1943, 9, 155–192.
Millonigg, R. C.: Isolation of an aminopeptidase from type B Clostridium botulinum. J. Bact. 1956, 72, 301–307.
Sandvik, O.: Studies on casein precipitation enzymes of aerobic and facultatively anaerobic bacteria. Thesis, Veterinary College of Norway 1962.
Skulberg, A.: Studies on the formation of toxin by Clostridium botulinum. Thesis, Veterinary College of Norway 1964.
Smith, E. L.: Peptide bond cleavage (survey). In The Enzymes. 2nd Ed. Vol. IV, p. 1. Acad. Press, New York 1960.
Snipe, P., I. Tessmer & H. Sommer: Acid precipitation of botulinum toxin. J. infect. Dis. 1928, 42, 152–160.
Wagner, E., K. F. Meyer & C. C. Dozier: Metabolism of Bacillus botulinum in various media. J. Bact. 1925, 10, 341–412.
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Proteolytic enzyme or protease are the terms used throughout this study. However, in this particular article the terms used by the respective investigators are applied.
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Tjaberg, T.B. Proteases of Clostridium Botulinum. Acta Vet Scand 14, 184–192 (1973). https://doi.org/10.1186/BF03547421
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DOI: https://doi.org/10.1186/BF03547421