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Carcinoma of the Small Intestine of Sheep in Iceland
A Pathological and Epizootiological Study
Carcinom i tyndtarmen hos får i Island. En patologisk og epizootiologisk undersøgelse
Acta Veterinaria Scandinavica volume 14, pages 392–409 (1973)
Abstract
This paper deals with an unusually high incidence, i.e. 0.97 % of carcinoma of the small intestine found in Icelandic sheep. The tumours were situated in the jejunum and upper ileum. The macroscopic and microscopic pathology is described and compared with carcinoma of the small intestine of domestic animals and humans.
Aetiological factors are discussed and the possibility of exposure to carcinogenic substances, especially nitrosamines in food concentrates, is suggested.
Finally these findings are discussed in relation to current ideas on carcinogenesis in the intestines.
Sammendrag
En usædvanlig høj incidens, d.v.s. 0.97 %, af carcinom i tyndtarmen observeret hos islandske får rapporteres. Svulsterne var lokaliserede til jejunum og den øverste del af ileum. Den makroskopiske og mikroskopiske patologi beskrives og sammenlignes med carcinom i tyndtarmen hos andre husdyr og mennesker.
Etiologiske faktorer diskuteres og den mulighed drøftes, at fårene er blevet udsat for carcinogene substanser, især nitrosaminer i kraftfoder.
Disse fund diskuteres med henblik på nugældende ideer om carcinogenese i tarmen.
References
Azzopardi, J. G. & D. J. Pollock: Argentaffin and argyrophil cells in gastric carcinoma. J. Path. Ract. 1963, 86, 443–451.
Burkitt,D.P.: Epidemiology of cancer of the colon and rectum. Cancer (Philad.) 1971, 28, 3–13.
Cordes, D. O. & E. H. Shortridge: Neoplasms of sheep: a survey of 256 cases recorded at Ruakura Animal Health Laboratory. N. Z. vet. J. 1971, 19, 55–64.
Cotchin, E.: Neoplasms of the domesticated mammals. Review Series No. 4 of the Commonwealth Rureau of Animal Health, Commonwealth Agricultural Rureaux, Farnham Royal, Rucks., England 1956.
Dodd, D. C.: Adenocarcinoma of the small intestine of sheep. N. Z. vet. J. 1960, 8, 109–112.
Ender, F., G. Havre, A. Helgebostad, N. Koppang, R. Madsen & L. Ceh: Isolation and identification of hepatotoxic factor in herring meal produced from sodium nitrite preserved herring. Naturwissenschaften 1964, 51, 637–638.
Evans, I. A.: The radiomimetic nature of bracken toxin. Cancer Res. 1968, 28, 2252–2261.
Evans, R. W.: Histological Appearances of Tumours. E. & S. Livingstone, Edinburgh and London 1966.
Koppang, N.: An outbreak of toxic liver injury in ruminants. Case reports pathological-anatomical investigations, and feeding experiments. Nord. Vet.-Med. 1964, 16, 305–322.
Koppang, N., P. Slagsvold, M. A. Hansen, E. Sögnen & R. Svenkerud: Feeding experiments with meal produced from herring preserved with sodium nitrite and formalin. Nord. Vet.-Med. 1964, 16, 343–362.
McDonald, J. W. & D. D. Leaver: Adenocarcinoma of the small intestine of merino sheep. Aust. vet. J. 1965, 41, 269–271.
McPeak, C. J.: Malignant tumors of the small intestine. Amer. J. Surg. 1967, 114, 402–411.
Monlux, A. W., W. A. Anderson & C. L. Davis: A survey of tumors occurring in cattle, sheep and swine. Amer. J. vet. Res. 1956, 17, 646–677.
Moulton, J. E.: Tumors in Domestic Animals. Univ. California Press, Berkeley and Los Angeles 1961.
Pearse, A. G. E.: Histochemistry. Vol. I. Churchill, London 1968.
Sakshaug, J., E. Sögnen, M. A. Hansen & N. Koppang: Dimethylnitrosamine, its hepatotoxic effect in sheep and its occurrence in toxic batches of herring meal. Nature (Lond.) 1965, 206, 1261–1262.
Schütte, K. H.: Esophageal tumors in sheep: some ecological observations. J. nat. Cancer Inst. 1968, 41, 821–824.
Webster, W. M.: Neoplasia in food animals with a special reference to the high incidence in sheep. N. Z. vet. J. 1966, 14, 203–214.
Webster, W. M.: A further survey of neoplasms in abattoir sheep. N. Z. vet. J. 1967, 15, 51–54.
Wood, D. A.: Tumors of the small intestines. Atlas of Tumor Pathology, Armed Forces Institute of Pathology, Washington D.C. 1967.
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Georgssonand, G., Vigfússon, H. Carcinoma of the Small Intestine of Sheep in Iceland. Acta Vet Scand 14, 392–409 (1973). https://doi.org/10.1186/BF03547427
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DOI: https://doi.org/10.1186/BF03547427