Skip to main content
Download PDF
  • Published:

Vitamin B12 in the Blood and in the Liver of Normal and of Totally Gastrectomized Pigs

Vitamin B12 i blod og lever fra normale og total gastrektomerede grise

Acta Veterinaria Scandinavica volume 14, pages 421–427 (1973)Cite this article

Abstract

The concentration of vitamin R12 in the blood was studied in five totally gastrectomized pigs followed for 10–18 months, and in four controls followed for 5¼–8 months. The concentration of vitamin B12 in the liver was investigated in three pigs of each group. The content of vitamin B12 in the blood was of the same magnitude in both groups. Thus, removal of the stomach does not compromise the normal presence of this vitamin in the blood. The B12 content in the liver was also unaffected by the operation, whereas it was increased after simultaneous administration of vitamin B6.

Sammendrag

Koncentrationen af vitamin B12 blev bestemt i blodet fra fem total gastrektomerede grise over en periode på 10–18 måneder, samt i fire kontrolgrise, som blev fulgt i 5¼–8 måneder. Koncentrationen af vitamin B12 i levervævet blev bestemt hos tre grise fra hver gruppe. Indholdet af vitamin B12 i blodet var af samme størrelsesorden hos de to grupper af grise. Indholdet af vitamin B12 i leveren ændredes ikke efter gastrektomien, hvorimod det øgedes ved indgift af vitamin B6.

References

  • Bence, J.: Die Rolle des Magens und der Leber in der Pathologie der perniziösen Anämie. (The role of the stomach and the liver for the pathology of pernicious anemia). Z. klin. Med. 1933, 126, 127–142.

    Google Scholar 

  • Dedichen, J.: Ref. in Landboe-Christensen, E. & C. L. S. Bohn 1946.

  • Geiger, A. J., L. S. Goodmann & L. N. Claiborn: Effects of gastrointestinal resections in swine on the antianemia potency of the liver. Yale J. Biol. Med. 1940/41, 13, 259–278.

  • Glass, G. B. J.: Gastric intrinsic factor and its function in the metabolism of vitamin B12. Physiol. Rev. 1963, 43, 529–849.

    Article  CAS  Google Scholar 

  • Gyrd-Hansen, N.: Anaesthesia in pigs using phencyclidine and halothane. Nord. Vet.-Med. 1971, 23, 281–287.

    CAS  PubMed  Google Scholar 

  • Harper, H. A.: Review of Physiological Chemistry. 8th Ed. Lange Medical Publications, Los Altos, California 1961.

  • Heinrich, H. C.: Radiometrische Intrinsic Factor-Studien am Menschen und am Schwein. (Radiometric studies of the intrinsic factor in man and in pigs). In Heinrich, H. C. (ed.): Vitamin B12 und Intrinsic Factor. Ferdinand Enke, Stuttgart 1957, pp. 213–240. 1st Europ. Symp., Hamburg 1956.

  • Hoedemaeker, P. J.: Investigations on the site of production of Castle’s gastric intrinsic factor. Thesis. Groningen 1965.

  • Hoff-Jørgensen, E.: Microbiological assay of vitamin B12. Meth. biochem. Anal. 1954, 1, 81–113.

    Google Scholar 

  • Håkansson, R., C. Owman & B. Sporrong: Parakrina celler i magtarmkanalen. (Paracrine cells in the gastro-intestinal tract). Nord. Med. 1971, 85, 169–174.

    Google Scholar 

  • Ivy, A. C.: The effects of gastrectomy in animals. Amer. J. dig. Dis. 1940, 7, 500–502.

    Article  Google Scholar 

  • Johnson, B. Connor: Vitamin B12 in animal nutrition. In Heinrich, H. C. (ed.): Vitamin B12 und Intrinsic Factor. Ferdinand Enke, Stuttgart 1957, pp. 133–155. 1st Europ. Symp., Hamburg 1956.

  • Kristensen, H. P. Østergaard: Vitamin B12-indholdet i Menneskeblod. (The contents of vitamin B12 in human blood). Thesis. Copenhagen 1958.

  • Landboe-Christensen, E. & C. L. S. Bohn: On the curative effect of pure duodenal secretion from swine in cases of pernicious anemia. Acta med. scand. 1947, 127, 116–129.

    Article  Google Scholar 

  • Landboe-Christensen, E. & E. Hoff-Jørgensen: Observations on the histotopographic localization of the vitamin B12 binding factor in the fundus, pylorus and duodenum. Acta path, microbiol. scand. 1955, Suppl. 105, 104–117.

  • Meulengracht, E.: Continued investigations on the presence of the antianaemic factor in preparations of dried stomach substance from the cardia, fundus and pylorus, and the duodenum. V. Preparations from the duodenum. Acta med. scand. 1935, 85, 79–88.

    Article  CAS  Google Scholar 

  • Petri, S.: Bibliography of the papers by Svend Petri up to 1955 appears in dissertationes in honorem Svenonis Petri sexagenarii. Acta path, microbiol. scand. 1955, Suppl. 105, 12–15.

  • Petri, S. & C. Petri: Effect of vitamin B6 upon gastroprival central nervous system degenerations. III. Acta med. scand. 1970, 187, 129–131.

    Article  CAS  Google Scholar 

  • Petri, S., J. Bing, Ejnar Nielsen & Aa. Kjerbye Nielsen: On deficiency of antipernicious-anemic principle in liver extract from swine after elective resection of the fundus of the stomach. Acta med. scand. 1941, 109, 59–76.

    Google Scholar 

  • Petri, S., F. Nørgaard & W. Kiær: Therapeutic experiments on pig with preventive parenteral administration of vitamin B6. Acta med. scand. 1944, 119, 356–363.

    Article  CAS  Google Scholar 

  • Petri, C., Folke Rasmussen & S. Petri: Anaemia in the totally gastrectomized pig. In Advance Abstracts, 4th World Congress of Gastroenterology, Danish Gastroent. Ass., Copenhagen 1970, p. 574.

  • Prinz, W., H. Hill & H. C. Heinrich: Über die Resorption von radioaktiven, Co-markierten Vitamin B12 und B12-ähnlichen Verbindungen bei normalen, gastrektomierten und mit Dünndarmkanülen versehenen Schweinen unter Verwendung von resorptionsbeeinflussenden Faktoren. (Studies on the absorption of radioactive cobalt-marked vitamin B12 and B10-analogues in the normal, gastrectomized and duodenal canulated pigs, using various factors influencing absorption). Zbl. Vet.-Med. 1959, 6, 605–624.

    CAS  Google Scholar 

  • Sharp, E. A., R. M. McKean & E. C. von der Heide: Pernicious anemia: The behavior of various extracts of stomach and duodenum used to induce remissions. Ann. intern. Med. 1931, 4, 1282–1286.

  • Votila, U.: On the antianemic function of the small intestine. Acta med. scand. 1938, 95, 415–432.

    Article  Google Scholar 

  • Wolff, R.: La position du foie dans le metabolisme normal et pathologique de la vitamine B12. (The importance of the liver in the normal and pathological metabolism of vitamin B12). In H. C. Heinrich (ed.): Vitamin B12 und Intrinsic Factor. Ferdinand Enke, Stuttgart 1957, pp. 519–537. 1st Europ. Symp., Hamburg 1956.

Download references

Author information

Authors and Affiliations

  1. Pathological Institutes of Øresundshospitalet and of the Geriatric Centre (“De Gamles By”), and the Institute of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870, Copenhagen V, Denmark

    S. Petri, C. Petri & Folke Rasmussen

Authors
  1. S. Petri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Petri
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Folke Rasmussen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Financially aided by a grant from the P. Carl Petersen Foundation.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Petri, S., Petri, C. & Rasmussen, F. Vitamin B12 in the Blood and in the Liver of Normal and of Totally Gastrectomized Pigs. Acta Vet Scand 14, 421–427 (1973). https://doi.org/10.1186/BF03547429

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03547429

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147