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Cerebro-Cortical Necrosis (C.C.N.) in Calf
An Experimental Reproduction of the Disease
Cerebro-cortical nekros (C.C.N.) hos kalv. En experimentell reproduktion av lidandet
Acta Veterinaria Scandinavica volume 14, pages 464–473 (1973)
Abstract
In four ruminant calves a state of thiamine deficiency was brought about with a thiamine antagonist, amprolium. Twice daily the calves were given Amprolmix® containing 25 % amprolium through a stomach tube. The dosage was 350–500 mg/kg body weight daily during the entire experimental period. After 31 days the first calf showed fully developed symptoms; two other calves fell ill after another four and eight days respectively. The fourth calf was killed before the disease became clinically manifest. In all calves cerebrocortical necroses were found on histological examination. The clinical picture is described. It was similar to that in spontaneous C.C.N.
In the calves exhibiting fully developed symptoms a moderate rise was observed in the pyruvate kinase and a heavy rise in the creatine Phosphokinase activity. On several occasions the total quantity of thiamine (free + phosphorylated) in the blood exceeded the upper normal limit without any extra supply of thiamine being given. Only on one occasion was a lowering observed, to a value just below the lower limit of normal variation.
Sammanfattning
Hos fyra idisslande kalvar framkallades ett tiaminbristtillstånd med hjälp av en tiaminantagonist, amprolium. Två gånger dagligen gavs kalvarna amprolmix® innehållande 25 % amprolium med strupsond. Doseringen var 350–500 mg per kg kroppsvikt dagligen under hela försöksperioden. Efter 31 dagar visade den första kalven fullt utvecklade symptom, två andra kalvar insjuknade efter ytterligare fyra respektive åtta dagar. Den fjärde kalven avlivades innan sjukdomen var kliniskt manifest. Hos samtliga kalvar kunde cerebro-corticala nekroser påvisas vid histologisk undersökning. En beskrivning av den kliniska bilden ges. Den överensstämde med den vid spontan C.C.N.
Hos de kalvar som visade fullt utvecklade symptom iakttogs en måttlig stegring av pyruvatkinas- och en kraftig stegring av creatin-phosphokinas-aktiviteten. Vid flera tillfällen översteg totalmängden tiamin (fritt + fosforylerat) i blodet den övre normalgränsen utan att någon extra tiamintillförsel hade skett. Endast vid ett tillfälle observerades en sänkning, till ett värde strax under nedre gränsen för normalvariationen.
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Lilja, CG. Cerebro-Cortical Necrosis (C.C.N.) in Calf. Acta Vet Scand 14, 464–473 (1973). https://doi.org/10.1186/BF03547433
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DOI: https://doi.org/10.1186/BF03547433