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Half-Lives of Sulphadoxine and Trimethoprim After a Single Intravenous Infusion in Cows

Acta Veterinaria Scandinavica volume 15, pages 356–365 (1974)Cite this article

Abstract

DAVITIYANANDA, DANIS and FOLKE RASMUSSEN: Half-lives of sulphadoxine and trimethoprim after a single intravenous infusion in cows. Acta vet. scand. 1974, 15, 356–365. — The half-life of sulphadoxine in plasma (11 hrs.) is much longer than that of trimethoprim (50–103 min.) and in accordance to this traces of sulphadoxine are demonstrated in the milk 3 days after the infusion, while trimethoprim could not be detected in milk 2 days after the infusion. The apparent volume of distribution is 0.37 for sulphadoxine and 1.14 for trimethoprim, i.e. 37 % and 114 % of the body weight, respectively.

sulphadoxine; trimethoprim; half-life; cow.

Sammanfattning

Halueringstiderne for sulfadoxin og trimethoprim efter en enkelt intravenøs infusion på køer.

Halveringstiden for sulfadoxin i blodplasma (t½ = 11 timer) er meget længere end halveringstiden for trimethoprim (50–103 min.). I overensstemmelse med dette påvistes der spor af sulfadoxin i mælken i 3 dage efter infusionen, mens der ikke kunne påvises rester af trimethoprim i mælken 2 dage efter infusionen. Fordelingsvolumnet er 0.37 for sulfadoxin og 1.14 for trimethoprim, d.v.s. henholdsvis 37 % og 114 % af legemsvægten.

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Authors and Affiliations

  1. Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Copenhagen, DK-1870, Denmark

    Danis Davitiyananda & Folke Rasmussen

  2. Department of Pharmacology, Veterinary Faculty, Bangkok, Thailand, P.R. China

    Danis Davitiyananda

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  1. Danis Davitiyananda
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  2. Folke Rasmussen
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Supported by the Danish Agricultural and Veterinary Research Council.

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Davitiyananda, D., Rasmussen, F. Half-Lives of Sulphadoxine and Trimethoprim After a Single Intravenous Infusion in Cows. Acta Vet Scand 15, 356–365 (1974). https://doi.org/10.1186/BF03547464

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Acta Veterinaria Scandinavica

ISSN: 1751-0147