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Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study

IV. Tissue Distribution and Elimination in Urine

Acta Veterinaria Scandinavica volume 15, pages 419–435 (1974)Cite this article

Abstract

LANNEK, BIRGITTA and PAUL LINDBERG: Toxicity of halogenated oxyquinolines in dogs. A clinical study. IV. Tissue distribution and elimination in urine. Acta vet. scand. 1974, 15, 419–435. — Distribution studies using 125I-labelled vioform given orally showed higher blood activity when fat was ingested. It is assumed that this is due to increased absorption from the gastrointestinal tract. Total activity eliminated in urine during 12 hrs. was well correlated with blood activity.

Distribution of activity in blood and tissues in dogs which were intoxicated and died did not show any significant traits as compared to dogs which remained healthy. The mortality was highest in dogs which were fed with fouled herring before the administration of fat and vioform.

vioform toxicity; halogenated oxyquinolines.

Sammanfattning

Toxiciteten av halogenerade oxikinoliner hos hund. En klinisk studie.

IV. Väunadsdistribution och elimination i urin.

Distributionsundersökningar med 125J-märkt vioform, vilket gavs perorait, visade högre blodaktivitet, när fett gavs samtidigt. Detta är troligen orsakat av ökad absorption från tarmkanalen. Total aktivitet eliminerad i urinen under 12 timmar var nära korrelerad med blodaktiviteten.

Distributionen av aktivitet i blod och vävnader hos hundar, vilka blev intoxikerade och dog, visade inga signifikanta drag i jämförelse med hundar som förblev friska.

Mortaliteten var högst hos hundar som gavs ruttnad strömming före tillförseln av fett och vioform.

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Authors and Affiliations

  1. Department of Medicine I, Royal Veterinary College, Stockholm 50, Stockholm, S-104 05, Sweden

    Birgitta Lannek & Paul Lindberg

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  1. Birgitta Lannek
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  2. Paul Lindberg
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Supported by grants from the Swedish Medical Research Council.

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Lannek, B., Lindberg, P. Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study. Acta Vet Scand 15, 419–435 (1974). https://doi.org/10.1186/BF03547468

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Acta Veterinaria Scandinavica

ISSN: 1751-0147