- Published:
Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study
IV. Tissue Distribution and Elimination in Urine
Acta Veterinaria Scandinavica volume 15, pages 419–435 (1974)
Abstract
LANNEK, BIRGITTA and PAUL LINDBERG: Toxicity of halogenated oxyquinolines in dogs. A clinical study. IV. Tissue distribution and elimination in urine. Acta vet. scand. 1974, 15, 419–435. — Distribution studies using 125I-labelled vioform given orally showed higher blood activity when fat was ingested. It is assumed that this is due to increased absorption from the gastrointestinal tract. Total activity eliminated in urine during 12 hrs. was well correlated with blood activity.
Distribution of activity in blood and tissues in dogs which were intoxicated and died did not show any significant traits as compared to dogs which remained healthy. The mortality was highest in dogs which were fed with fouled herring before the administration of fat and vioform.
vioform toxicity; halogenated oxyquinolines.
Sammanfattning
Toxiciteten av halogenerade oxikinoliner hos hund. En klinisk studie.
IV. Väunadsdistribution och elimination i urin.
Distributionsundersökningar med 125J-märkt vioform, vilket gavs perorait, visade högre blodaktivitet, när fett gavs samtidigt. Detta är troligen orsakat av ökad absorption från tarmkanalen. Total aktivitet eliminerad i urinen under 12 timmar var nära korrelerad med blodaktiviteten.
Distributionen av aktivitet i blod och vävnader hos hundar, vilka blev intoxikerade och dog, visade inga signifikanta drag i jämförelse med hundar som förblev friska.
Mortaliteten var högst hos hundar som gavs ruttnad strömming före tillförseln av fett och vioform.
References
Berggren, L. & O. Hansson: Absorption of intestinal antiseptics derived from 8-hydroxyquinolines. Clin. Pharmacol. Ther. 1968, 9, 67–70.
Best, C. H. & N. B. Taylor: The Physiological Basis of Medical Practice. 8th Ed. The Williams & Wilkins Company, Baltimore 1966.
Bradlow, H. L.: The hydrolysis of steroid conjugates. In Chemical and Biological Aspects of Steroid Conjugation. Bernstein, S. & S. Solomon, ed. Springer Verlag, Berlin, Heidelberg, New York 1970, 131–181.
Comar, C. L.: Radioisotopes in Biology and Agriculture. Mc Craw-Hill Book Co., Inc. New York 1955, p. 173.
David, N. A., N. M. Phatak & F. B. Zener: Iodochlorhydroxyquinoline and diiodohydroxyquinoline : Animal toxicity and absorption in man. Amer. J. trop. Med. 1944, 24, 29–33.
Goodman, L. S. & A. Gilman: The Pharmacological Basis of Therapeutics. 4th Ed. The Macmillan Company, New York 1971.
Hangartner, P.: Troubles nerveux observés chez le chien après absorption d’Entéro-Vioforme Ciba. (Nervous symptoms observed in dogs after absorption of Enterovioform Ciba). Schweiz. Arch. Tierheilk. 1965, 107, 43–47.
Haskins, W. T. & G. W. Luttermoser: Spectrometric determination of 8-Quinolinol. Analyt. Chem. 1951, 23, 456–458.
Haskins, W. T. & G. W. Luttermoser: Urinary excretion of; vioform and diodoquin in rabbits. J. Pharmacol. exp. Ther. 1953, 109, 201–205.
Haskins, W. T., G. W. Luttermoser & F. J. Brady: The physiological disposition of diodoquin, vioform and chiniofon in the rabbit as determined with radioiodine. Amer. J. trop. Med. 1950, 30, 599–612.
de la Huerga, J., C. Yesinick & H. Popper: Estimation of total serum lipids by a turbidimetric method. Amer. J. clin. Path. 1953, 23, 1163–1167.
Knight, A. A. & J. Miller: Comparative studies on the iodine absorption of Anayodin, Chiniofon, Diodoquin, and Vioform in man. Ann. intern.. Med. 1949, 30, 1180–1187.
Korzun, B. P., S. M. Brody & F. Tishler: Thin-layer chromatography of iodochlorhydroxyquin. J. pharm. Sci. 1964, 53, 976–977.
Lannek, B.: Toxicity of halogenated oxyquinolines in dogs. A clinical study. I. A survey of cases. Acta vet. scand. 1973, 14, 723–744.
Lannek, B.: Toxicity of halogenated oxyquinolines in dogs. A clinical study. II. History, symptoms, laboratory findings, therapy, and follow-up. Acta vet. scand. 1974, 15, 219–238.
Lannek, B. & L. Jönsson: Toxicity of halogenated oxyquinolines in dogs. A clinical study. V. Pathological findings. Acta vet. scand. 1974, 15. In press.
Lannek, B. & P. Lindberg: Vioform poisoning in dogs. The absorption of vioform from the intestine. Svensk Vet.-Tidn. 1972, 11, 438–441.
Lannek, B. & P. Lindberg: Toxicity of halogenated oxyquinolines in dogs. A clinical study. III. Intoxication experiments. Acta vet. scand. 1974, 15, 398–418.
Liewendahl, K., V. Kivakongas & B-A Lamberg: Metabolism of 125iodochloroxyquinoline in man. II. Metabolites in plasma, urine and faeces. Nucl.-Med. (Stuttg.) 1967, 6, 32–43.
Müller, L. F.: Die Mexaformvergiftung des Hundes (Klinische Demonstration) . (The mexaform poisoning in the dog. Clinical demonstration). Kleintier-Prax. 1967, 12, 51–52.
Palm, A.: Untersuchungen in der Chinolinreihe. X. Mitteilung: Dijodverbindungen. (Investigations of the quinoline derivatives. X. Communication : Diiodocompounds). Naunyn-Schmiedeberg’s Arch. exp. Path. Pharmak. 1932, 166, 176–185.
Püschner, H. & R. Fankhauser: Neuropathologische Befunde bei experimenteller Vioform-Vergiftung der weissen Maus. (Neurological symptoms after experimental Vioform poisoning in the white mouse). Schweiz. Arch. Tierheilk. 1969, 111, 371–379.
Ritter, P. & M. Jermann: Vergleichende Untersuchungen über Resorption und Stoffwechsel einiger therapeutisch angewendeter 8-hydroxychinolin. (Comparative study on the absorption and the metabolism of some 8-hydroxyquinolines for therapeutic use). Arzneimittel-Forsch. 1966, 16, 1647–1652.
Rodriguez, L. A. & J. A. Close: The metabolism of the 5-7-dibromo-8-hydroxyquinoline (Broxyquinoline) in man. Biochem. Pharmacol. 1969, 17, 1647–1653.
Schantz, B. & B. Wikström: Suspected poisoning with oxyquinoline preparations in dogs. Svensk Vet.-Tidn. 1965, 4, 106–107.
Sen-Gupta, T.: Preparation of 5-chloro-7-iodo-8-oxyquinoline. J. Indian chem. Soc. 1945, 22, 171–172.
Author information
Authors and Affiliations
Additional information
Supported by grants from the Swedish Medical Research Council.
Rights and permissions
About this article
Cite this article
Lannek, B., Lindberg, P. Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study. Acta Vet Scand 15, 419–435 (1974). https://doi.org/10.1186/BF03547468
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1186/BF03547468