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Senile Cardiac Amyloidosis in The Dog
Amyloidos i hjårtat hos hund
Acta Veterinaria Scandinavica volume 15, pages 206–218 (1974)
Abstract
Thirty-two cases of senile cardiac amyloidosis from a routine necropsy material of 594 dogs were studied. The age of the affected dogs ranged from 10 to 16 years. Amyloid was observed in the intramural arteries and arterioles, predominantly in the ventricular myocardium. The vessels were often obturated with amyloid, and myocardial necroses and fibroses were common consequences of the vascular lesions. In three cases amyloid deposits were also observed in the main subepicardial coronary arteries. In contrast to man, only slight interstitial amyloid degeneration was found in four of the dogs observed. Amyloid in the mitral valves, tricuspid valves and aortic cusps was observed in six, two and three cases respectively. It was concluded that the distribution of senile cardiac amyloidosis in the heart of the dog differs considerably from that in man.
Sammanfattning
Av 594 obducerade hundar påvisades 32 fall av senil hjärtamyloidos. Åldern varierade melian 10 och 16 år. Amyloid påvisades i intramurala artärer och arterioler, huvudsakligen i kammarmuskulaturen. Kärlen var ofta obturerade av amyloid. Nekroser och fibroser i hjärtmuskulaturen var vanliga komplikationer till kärlskadorna. I tre fall påvisades amyloid även i de stora extramurala kransartärerna. I motsats till förhållandet hos människa sågs sällan interstitiell amyloid degeneration. I endast fyra fall förekom lindriga amyloiddepositioner av denna typ. Amyloid i mitralisklaffar, tricuspidalisklaffar och aortaklaffar förekom i sex, två respektive tre fall. Undersökningen har visat att primär hjärtamyloidos endast förekommer hos gamla hundar, och att förändringarna huvudsakligen är lokaliserade tili hjärtats intramurala artärer och arterioler.
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Jönsson, L. Senile Cardiac Amyloidosis in The Dog. Acta Vet Scand 15, 206–218 (1974). https://doi.org/10.1186/BF03547482
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DOI: https://doi.org/10.1186/BF03547482