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Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study
II. History, Symptoms, Laboratory Findings, Therapy, and Follow-Up
Toxiciteten av halogenerade oxikinoliner hos hund. En klinisk studie. II. Anamnes, symptombild, laboratorieundersökningar, terapi och uppföljning
Acta Veterinaria Scandinavica volume 15, pages 218–238 (1974)
Abstract
Intoxication due to short-term oxyquinoline therapy was studied in 100 dogs, which had been so treated because of diarrhoea (except in 2 cases). The latter condition was in itself mild and uncomplicated. The main symptoms of intoxication were listlessness or excitation and nervousness, aggressiveness, tremor, convulsions, and salivation. Clinical examination revealed myocarditis and liver injury. Mortality, i.e. the sum of spontaneous deaths and euthanasia, amounted to 30 %. The treatment considered to be most important was sedation and anticonvulsant measures. It was further essential to correct the dehydration, which was often present. A follow-up investigation showed that approx. 1/3 of the dogs which had recovered from the acute intoxication developed recurrent convulsions within the next 3 years.
Sammanfattning
Hundra fall av oxikinolinförgiftning hos hund har studerats. Behandling med oxikinoliner hade (utom i 2 fall) företagits på grund av att hundarna led av en lindrig, okomplicerad diarré. Symptomen utgjordes främst av slöhet eller exitation och nervositet, aggressivitet, muskelryckningar, kramper och salivation. Den kliniska undersökningen avslöjade myokardit och leverskada. Mortaliteten, summan av spontant döda och avlivade fall, var 30 %. Den viktigaste behandlingen är sedativ och antikonvulsiv terapi samt att korrigera den ofta föreliggande dehydreringen. En efterkontroll visar, att ungefär en tredjedel av de hundar som tillfrisknat från det akuta förgiftningstillståndet under de närmast 3 kommande åren får återkommande epileptiska anfall.
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Supported by grants from the Swedish Medical Research Council.
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Lannek, B. Toxicity of Halogenated Oxyquinolines in Dogs. A Clinical Study. Acta Vet Scand 15, 218–238 (1974). https://doi.org/10.1186/BF03547483
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DOI: https://doi.org/10.1186/BF03547483