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Liver Abscesses in Intensively Fed Cattle

Serial Investigations of Serum Proteins

Leverabscesser hos intensivt uppfödda kalvar. Serieundersökningar av serumproteiner

Abstract

An attempt was made to determine the time of onset of liver abscesses in intensively fed calves. Determinations of seram proteins (total protein, albumin, globulin, albumin/ globulin ratio, agarose-gel electrophoretic separation and formol-gel test) and, in a part of the material, of serum-GOT and -GPT were made in serial samples taken once a month from 125 calves. Liver abscesses were found in 48 (38.4 %) when slaughtered at 6–7 months of age.

Total protein and globulin increased, the albumin-globulin ratio decreased with increasing age. Calves with liver abscesses had a significantly (0.05 > P > 0.01) higher globulin concentration at the last sampling. At this sampling the material was of a limited size and the difference has to be interpreted with caution. No other significant differences were found. Nor were any rises observed in S-GOT and S-GPT referable to the formation of liver abscesses.

Bacteriological studies were not made but, in analogy with observations on a similar animal material in another part of Sweden, the infectious agent in the liver abscesses was assumed to be Sph. necrophorus. The explanation of the almost absent changes in the serum proteins in calves with liver abscesses may be the low antigenicity of this bacterium.

In conclusion it is stated that the present serial investigations of the serum protein pattern in young cattle provide no definite guidance for establishing the time of onset of liver abscesses.

Sammanfattning

För att försöka bestämma tidpunkten för uppkomsten av leverabscesser hos intensivt uppfödda kalvar gjordes bestämningar av serumproteiner (totalprotein, albumin, globulin, AG-kvot, agarosgelelektroforetisk separation samt formol-geltest) och på en del av materialet av serumaktiviteten av GOT och GPT i serieprover, tagna en gång per månad på 125 kalvar. Leverabscesser konstaterades hos 48 st (38.4 %) då de slaktades vid 6–7 månaders ålder.

Totalprotein och globulin ökade medan AG-kvoten minskade med stigande ålder. Kalvar med leverabscesser hade signifikant (0.05 > Ρ > 0.01) högre globulinkoncentration vid sista provtagningen. Materialets begränsade storlek vid detta tillfälle gör att skillnaden, måste tolkas med försiktighet. Inga andra signifikanta skillnader konstaterades. Någon ökning av serum GOT och GPT som kunde hänföras till leverabscessernas uppkomst, observerades inte.

Bakteriologiska undersökningar utfördes inte men det antas att — i analogi med observationer på liknande djurmaterial i en annan del av Sverige — infektionsämnet i leverabscesserna var Sph. necrophorus. Förklaringen tili de uteblivna förändringarna i serumproteiner hos kalvar med leverabscesser skulle kunna vara denna bakteries låga antigenicitet.

Som slutsats framhålles att de utförda serieundersökningarna over serumproteinmönstret hos unga nötkreatur inte ger någon ledning för att bestämma tidpunkten för leverabscessernas uppkomst.

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The investigations were carried out with financial support from the Swedish Council for Forestry and Agricultural Research.

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Jönsson, G., Liberg, P. Liver Abscesses in Intensively Fed Cattle. Acta Vet Scand 15, 264–273 (1974). https://doi.org/10.1186/BF03547487

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