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Ovine White-Liver Disease (OWLD). Changes in Blood Chemistry
Kvitleversjuke (kobolt/vitamin B12 mangel) hos lam. Klinisk patologi
Acta Veterinaria Scandinavica volume 31, pages 277–286 (1990)
Abstract
Changes in blood chemistry were examined in vitamin B12 deficient lambs which developed ovine white-liver disease (OWLD), and were compared with values of cobalt/B12 supplemented lambs on the same pastures, as well as clinically healthy, but sometimes B12 deficient, lambs on other pastures (H). In the OWLD group, signs of hepatic damage were seen concurrently with reduction in weight gain, or 1–3 weeks before, and comprised elevation of serum glutamate dehydrogenase (GLDH) and decrease of phospholipid and cholesterol. Drop of plasma glucose and elevation of γGT also came in the earlier phase of the disease. All other blood changes developed later, and were partly regarded as reflections of the inappetence or hepatic injury. The changes included a drop in packed cell volume (PCV) and mean corpuscular volume (MCV), elevation of serum iron, and reduction of total serum protein and urea. Generally Co/B12 supplementation prevented hepatic damage and normalized blood values. The clinically healthy H lambs also showed signs of hepatic damage, especially one year when they were B12 deficient, indicating that simple B12 deficiency causes a moderate liver damage as well. For diagnostic purposes, clinical pathology is recommended mainly on a flock basis.
Sammendrag
Vitamin B12-deficitte lam som utviklet kvitleversjuke (OWLD) ble undersøkt klinisk-patologisk, og verdiene ble sammenliknet med resultatene hos kobolt/B12 doserte lam på de samme beitene, og klinisk friske, men noen ganger B12-deficitte, lam på andre beiter (H). Økning av serum glutamat dehydrogenase (GLDH) og nedsatt fosfolipid- og kolesterolnivå forekom enten samtidig med reduksjon i tilvekst, eller 1–3 veker før, når lamma var 8–10 veker gamle. Fall i plasma glukose og økning av γGT kom også i den tidlige fasen av sjukdommen. Alle andre forandringer i blodbildet kom senere, og ble hovedsakelig vurdert som en følge av nedsatt matlyst og leverskade. Forandringene omfattet fall i PCV og MCV, stigning i serumjern, og reduksjon av serumprotein og urea. Dosering med Co/B12 forhindret leverskade og normaliserte blodverdiene. H-lamma viste også tegn på en viss leverskade, spesielt da de var B12-deficitte, noe som indikerer at det ved simpel B12 mangel også er en moderat leverskade. Ved diagnostiske undersøkeiser anbefales klinisk kjemi gjennomført på flokkbasis.
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Ulvund, M.J. Ovine White-Liver Disease (OWLD). Changes in Blood Chemistry. Acta Vet Scand 31, 277–286 (1990). https://doi.org/10.1186/BF03547540
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DOI: https://doi.org/10.1186/BF03547540