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Ovine White-Liver Disease (OWLD). Serum Copper and Effects of Copper and Selenium Supplementation

Kvitleversjuke (kobolt/vitamin Β12 mangel) hos lam. Serum kopper og effekt av dosering med kopper og selen

Acta Veterinaria Scandinavica volume 31, pages 287–295 (1990)Cite this article

Abstract

Serum copper was generally higher in lambs affected with ovine white-liver disease (OWLD) than in cobalt/vitamin B12 supplemented lambs grazing the same pastures. Although the copper content of the grass was very low on the OWLD pastures, dosing lambs with Cu alone resulted in worsening of the clinical condition and aggravation of clinical pathology. Dosing with selenium had no effect on OWLD. Dosing with a combination of Co, Se and Cu resulted in normal lamb growth and normal laboratory tests. Lambs growing well on other pastures (H) showed elevated serum Cu when they were subclinically B12 deficient.

Sammendrag

Serum kopper var som regel høyere hos lam med kvitleversjuke (OWLD) enn hos dem som fikk tilskudd av kobolt eller vitamin Β12. Til tross for att graset på sjukdomsbeitene var kopperfattig ble sjukdomstilstanden forverret når lam på disse beitene ble dosert med kopper, og forandringene i blodbildet ble forsterket. Dosering med selen hadde ingen virkning på sjukdommen. Dosering med en kombinasjon av kobolt, selen og kopper resulterte i normal tilvekst, og normale forhold i blodbildet. Kontrollama viste stigning i serum kopper når de var subklinisk Co/B12 deficitte.

References

  • Allen WM, Sansom BF, Gleed PT, Mallinsom CB, Drake CF: Boluses of controlled release glass for supplementing ruminants with copper. Vet. Rec. 1984, 115, 55–57.

    Article  CAS  Google Scholar 

  • Andrews ED, Grant AB, Stephenson BJ: Weight responses of sheep to cobalt and selenium in relation to vitamin B12 and selenium concentrations in liver and kidney. N. Z. J. agric. Res. 1964, 7, 17–27.

    Article  CAS  Google Scholar 

  • Blaxter KL: The effect of selenium administration on the growth and health of sheep on Scottish farms. Brit. J. Nutr. 1963, 17, 105–115.

    Article  CAS  Google Scholar 

  • Care AD, Anderson PJB, Illingworth DV, Zervas G, Telfer SB: The effect of soluble-glass on the copper, cobalt and selenium status of Suffolk Cross lambs. In: Mills CF, Bremner I, Chesters JK (eds.): Trace elements in Man and Animals. TEMA-5. Proc. 5th int. Symp. on trace elements in man and animals, Aberdeen 1984, CAB, London 1985, p. 717–719.

  • Corrigall W, Dalgarno AC, Ewen LA, Williams RB: Modulation of plasma copper and zinc concentrations by disease states in ruminants. Vet. Rec. 1976, 99, 396–397.

    Article  CAS  Google Scholar 

  • Driver PM, Eames C, Telfer SB: Efficacy of soluble glass boluses containing copper, cobalt and selenium in store lambs. In: Proc. 6th int. Conf. on production disease in farm animals, Belfast 1986, 108–111.

  • Ellis NJS, Shallow M, Judson GJ: Weight gains of lambs treated with a soluble glass bullet containing cobalt, selenium and copper. Aust. vet. J. 1987, 64, 93–94.

    Article  CAS  Google Scholar 

  • Gardiner MR: Chronic selenium toxicity studies in sheep. Aust. vet. J. 1966a, 42, 442–448.

  • Gardiner MR: Mineral metabolism in sheep lupinosis. J. comp. Path. 1966b, 76, 107–120.

  • Hannam RJ, Judson GJ, Reuter DJ, McLaren LD, McFarlane JD: Effect of vitamin B12 injections on the growth of young merino sheep. Aust. J. agric. Res. 1980, 31, 347–355.

    Article  Google Scholar 

  • Hartley WJ, Drake C, Grant AB: Selenium and animal health. N. Z. J. agric. 1959, 99, 259–264.

    CAS  Google Scholar 

  • Hill MK, Walker SD, Taylor AG: Effects of marginal deficiences of copper and selenium on growth and productivity of sheep. N. Z. J. agric. Res. 1969, 12, 261–270.

    Article  CAS  Google Scholar 

  • Howell J McC: The effect of experimental copper deficiency on growth, reproduction and haemopoiesis in the sheep. Vet. Rec. 1968, 83, 226–227.

    Article  CAS  Google Scholar 

  • Knott P, Algar B, Zervas G, Telfer SB: Glass – a medium for providing animals with supplementary trace elements. In: Mills CF, Bremner I, Chesters JK (eds.): Trace elements in man and animals. TEMA-5. Proc. 5th int. Symp. on trace elements in man and animals, Aberdeen 1984. CAB, London 1985, p. 708–714.

  • Lee HJ: Cobalt and copper deficiencies affecting sheep in South Australia. J. Dep. Agric. S. Aust. 1951, 54, 475–532.

    CAS  Google Scholar 

  • Lee HJ: Trace elements in animal production. In: Nicholas DJD, Egan AR (eds.): Trace elements in soil-plant-animal systems. Academic Press, London 1975, p. 39–54.

  • MacPherson A, Moon FE, Voss RC: Some effects of feeding young steers on a diet deficient in both cobalt and copper. Brit. vet. J. 1973, 129, 414–426.

    Article  CAS  Google Scholar 

  • MacPherson A, Moon FE, Voss RC: Biochemical aspects of cobalt deficiency in sheep with special reference to vitamin status and a possible involvement in the eatiology of cerebral necrosis. Brit. vet. J. 1976, 132, 294–308.

  • Marston HR, Thomas RG, Murnane D, Lines EWL, McDonald IW, Moore HO, Bull LB: Studies on coast disease of sheep in South Australia. Commonwealth Scientific and Industrial Res. Org., Melbourne 1938 (Bull. no. 113).

  • McLean JW, Thompson CG, Claxton JH: Growth responses to selenium in lambs. N. Z. vet. J. 1959, 7, 47–52.

    Article  CAS  Google Scholar 

  • Millar KR, Meads Wj, Albyt AT, Scahill BG, Sheppard AD: The retention and efficacy of soluble glass boluses for providing selenium, cobalt and copper to sheep. N. Z. vet. J. 1988, 36, 11–14.

    Article  CAS  Google Scholar 

  • Mitchell PJ, McOrist S, Thomas KW, McCausland IP: White liver disease of sheep. Aust. vet. J. 1982, 58, 181–184.

    Article  CAS  Google Scholar 

  • Robertson TG, During C: Live weight responses to selenium in lambs, but few responses to cobalt. N. Z. J. Agric. 1961, 103, 306–310.

    Google Scholar 

  • Schwan O, Jacobsson SO, Frank A, Rudby-Martin L, Peters son LR: Cobalt and copper deficiency in Swedish landrace pelt sheep. Application of diagnosis in flock-related deficiency diseases. J. vet. Med. A, 1987, 34, 709–718.

    Article  CAS  Google Scholar 

  • Seaman JT: Pyrrolizidine alkaloid poisoning of sheep in New South Wales. Aust. vet. J. 1987, 64, 164–167.

    Article  CAS  Google Scholar 

  • Sutherland RJ, Cordes DO, Carthew GC: Ovine white liver disease – an hepatic dysfunction associated with B12 deficiency. N. Z. vet. J. 1979, 27, 227–232.

    Article  CAS  Google Scholar 

  • Suttle NF, Jones DG, Woolliams JA, Woolliams C, Wiener G: Growth responses to copper and selenium in lambs of different breeds on improved hill pastures. Proc. Nutr. Soc. 1984, 43, 103 A.

  • Suttle NF: Copper deficiency in ruminants; recent developments. Vet. Rec. 1986, 119, 519–522.

    Article  CAS  Google Scholar 

  • Telfer SB, Zervas G, Carlos G: Curing or preventing deficiencies in copper, cobalt and selenium in cattle and sheep using tracerglass. Canad. J. anim. Sci. 1984, 64, 243–235.

    Article  Google Scholar 

  • Ulvund MJ: Ovine white-liwer disease (OWLD). Vitamin B12 and methylmalonic acid (MMA) estimations in blood. Acta vet. scand. 1990a, 31, 267–275.

  • Ulvund MJ: Ovine white-liver disease (OWLD). Changes in blood chemistry. Acta vet. scand. 1990b, 31, 277–286.

  • Ulvund MJ, Pestalozzi M: Ovine white-liver disease (OWLD) in Norway: Clinical symptoms and preventive measures. Acta vet. scand. 1990a, 31, 53–62.

  • Ulvund MJ, Pestalozzi M: Ovine white-liver disease (OWLD). Botanical and chemical composition of pasture grass. Acta vet. scand. 1990b, 31, 257–265.

  • Whitelaw A, Armstrong RH, Evans CC, Fawcett AR: An investigation into copper deficiency in young lambs on an improved hill pasture. Vet. Rec. 1977, 101, 229–230.

    Article  CAS  Google Scholar 

  • Whitelaw A, Armstrong RH, Evans CC, Fawcett AR: A study of the effects of copper deficiency in Scottish blackface lambs on improved hill pasture. Vet. Rec. 1979, 104, 455–460.

    Article  CAS  Google Scholar 

  • Whitelaw A, Armstrong RH, Evans CC, Fawcett AR, Russell AJF: Effects of oral administration of copper oxide needles to hypocupraemic sheep. Vet. Rec. 1980, 107, 87–88.

    Article  CAS  Google Scholar 

  • Whitelaw A, Russell AJF, Armstrong RH, Evans CC, Fawcett AR, MacDonald AJ: Use of cupric oxide needles in the prophylaxis of induced copper deficiency in lambs grazing improved hill pastures. Vet. Rec. 1983, 112, 382–384.

    Article  CAS  Google Scholar 

  • Wiener G, Hall JG, Hayter S, Field AC, Suttle NF: Relationships between haemoglobin type and copper concentrations in whole blood and its components in sheep of different breeds. Anim. Prod. 1974, 19, 291–299.

    Google Scholar 

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  1. State Veterinary Research Station for Small Ruminants, P. O. Box 264, N-4301, Høyland, Sandnes, Norway

    Martha J. Ulvund

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Ulvund, M.J. Ovine White-Liver Disease (OWLD). Serum Copper and Effects of Copper and Selenium Supplementation. Acta Vet Scand 31, 287–295 (1990). https://doi.org/10.1186/BF03547541

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Acta Veterinaria Scandinavica

ISSN: 1751-0147