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Ultrastructure of Colonic Epithelial Cells in Vitamin E and Selenium Deficient Pigs

Ultrastrukturelle forandringer i kolonepíteleeller ved vitamin E-og selenmangel hos gris

Abstract

Pigs deficient in vitamin E and selenium had a decreased contrast of the intracellular membranes compared with pigs supplemented with vitamin E and selenium. Other common changes in the deficient animals included a reduced number of microvilli, with a short and irregular appearance, numerous swollen mitochondria with empty spaces and intercellular oedema. It is suggested that these morphological changes are attributed to the insufficient supply of vitamin E and selenium, though it is not excluded that particular intestinal factors may participate in the development of the lesions.

Sammendrag

Mangelgrisene viste nedsatt kontrast i de intracellulære membraner i epitelcellene i kolon sammenlignet med griser gitt tilskudd av vitamin E og selen. Av andre forandringer som ofte opptrådte hos mangeldyra var et redusert antall microvilli med et kort og uregelmessig utseende, oppsvulmede mitokondrier og ødem mellom cellene. Disse morfologiske forandringer er tilskrevet den mangelfulle tilførsel av vitamin E og selen, selvom man ikke utelukker at intestinale faktorer kanskje kan ha deltatt i utviklingen av lesjonene. Det er videre fremhevet at griser fra ett av eksperimentene hadde tydeligere membraner enn de andre dyra som ble undersøkt.

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Teige, J., Nafstad, P.H.J. Ultrastructure of Colonic Epithelial Cells in Vitamin E and Selenium Deficient Pigs. Acta Vet Scand 19, 549–560 (1978). https://doi.org/10.1186/BF03547594

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