- Published:
Ultrastructure of Colonic Epithelial Cells in Vitamin E and Selenium Deficient Pigs
Ultrastrukturelle forandringer i kolonepíteleeller ved vitamin E-og selenmangel hos gris
Acta Veterinaria Scandinavica volume 19, pages 549–560 (1978)
Abstract
Pigs deficient in vitamin E and selenium had a decreased contrast of the intracellular membranes compared with pigs supplemented with vitamin E and selenium. Other common changes in the deficient animals included a reduced number of microvilli, with a short and irregular appearance, numerous swollen mitochondria with empty spaces and intercellular oedema. It is suggested that these morphological changes are attributed to the insufficient supply of vitamin E and selenium, though it is not excluded that particular intestinal factors may participate in the development of the lesions.
Sammendrag
Mangelgrisene viste nedsatt kontrast i de intracellulære membraner i epitelcellene i kolon sammenlignet med griser gitt tilskudd av vitamin E og selen. Av andre forandringer som ofte opptrådte hos mangeldyra var et redusert antall microvilli med et kort og uregelmessig utseende, oppsvulmede mitokondrier og ødem mellom cellene. Disse morfologiske forandringer er tilskrevet den mangelfulle tilførsel av vitamin E og selen, selvom man ikke utelukker at intestinale faktorer kanskje kan ha deltatt i utviklingen av lesjonene. Det er videre fremhevet at griser fra ett av eksperimentene hadde tydeligere membraner enn de andre dyra som ble undersøkt.
References
Brown, J. H. & S. H. Pollock: Stabilization of hepatic lysosomes of rats by vitamin E and selenium in vivo as indicated by thermal labilization of isolated lysosomes. J. Nutr. 1972, 102, 1413–1419.
Callinan, R. B. & E. G. Russell: Aetiology and pathogenesis of swine dysentery - recent advances. Aust. vet. J. 1975, 51, 423–427.
Combs, G. F. Jr., T. Noguchi & M. L. Scott: Mechanisms of action of selenium and vitamin E in protection of biological membranes. Fed. Proc. 1975, 34, 2090–2095.
Diplock, A. T.: The nutritional and metabolic roles of selenium and vitamin E. Proc. Nutr. Soc. 1974, 33, 315–322.
Drees, D. T. & G. L. Waxier: Enteric colibacillosis in gnotobiotic swine: An electron microscopic study. Amer. J. vet. Res. 1970, 31, 1159–1171.
Glock, R. D.: Studies on the etiology, hematology and pathology of swine dysentery. Thesis, Iowa State Univ. 1971, 169 pp.
Grant, C. A.: Morphological and aetiological studies of dietetic microangiopathy in pigs (“Mulberry heart”). Acta vet. scand. 1961, 2, Suppl. 3.
Hayward, A. F. & H. S. Johnston: The fine structure of the epithelium of the colon in the mouse. Scot. med. J. 1961, 6, 416–425.
Jenkins, K. J. & M. Hidiroglou: A review of selenium/vitamin E responsive problems in livestock: A case for selenium as a feed additive in Canada. Canad. J. Anim. Sci. 1972, 52, 591–620.
Kenworthy, R., J. M. Stubbs & G. Syme: Ultrastructure of small- intestinal epithelium in weaned and unweaned pigs and pigs with post-weaning diarrhoea. J. Path. Bact. 1967, 93, 493–498.
Lucy, J. A.: Functional and structural aspects of biological membranes: A suggested structural role for vitamin E in the control of membrane permeability and stability. Proc. int. conf, vitamin E and its role in cellular metabolism. Ann. N. Y. Acad. Sci. 1972, 203, 4–11.
Molenaar, L., F. A. Hommes, W. G. Braams & H. A. Potman: Effect of vitamin E on membranes of the intestinal cell. Proc. nat. Acad. Sci. (Wash.) 1968, 61, 982–988.
Molenaar, J., J. Vos, F. C. Jager & F. A. Hommes: The influence of vitamin E deficiency of biological membranes. An ultrastruc- tural study on the intestinal epithelial cells of ducklings. Nutr. Metabol. 1970, 12, 358–370.
Mouwen, J. M. V. M.: White scours in piglets at three weeks of age. Thesis, Univ. Utrecht 1972, 116 pp.
Nafstad, I. & S. Tollersrud: The vitamin E-deficiency syndrome in pigs. I. Pathological changes. Acta vet. scand. 1970, 11, 452–480.
Porta, E. A., F. A. de la Iglesia & W. S. Hartroft: Studies on dietary hepatic necrosis. Lab. Invest. 1968, 18, 283–297.
Schofield, G. C. & A. M. Atkins: Secretory immunoglobulin in columnar epithelial cells of the large intestine. J. Anat. (Lond.) 1970, 107, 491–504.
Sibalin, M. & N. Bjorkman: On the fine structure and absorptive function of the porcine jejunal villi during the early suckling period. Exp. Cell Res. 1966, 44, 165–174.
Taylor, D. J. & W. F. Blakemore: Spirochaetal invasion of the colonic epithelium in swine dysentery. Res. Vet. Sci. 1971, 12, 177–179.
Teige, J. Jr., K. Nordstoga & J. Aursjo: Influence of diet on experimental swine dysentery. 1. Effects of a vitamin E and selenium deficient diet supplemented with 6.8 % cod liver oil. Acta vet. scand. 1977, 18, 384–396.
Teige, J. Jr., F. Saxegaard & A. Froslie: Influence of diet on experimental swine dysentery. 2. Effects of a vitamin E and selenium deficient diet supplemented with 3 % cod liver oil, vitamin E or selenium. Acta vet. scand. 1978, 19, 133–146.
Thake, D. C.: Jejunal epithelium in transmissible gastroenteritis of swine. An electron microscopic and histochemical study. Amer. J. Path. 1968, 53, 149–168.
Vos, J.: Cellulaire membranen bij vitamine E gebrek. Een ultrastruk- tureel en biochemisch onderzoek van de lever bij de Peking- eend. (Cellular membranes in vitamin E deficiency. An ultra- structural and biochemical study on the liver of the Peking- duckling). Thesis, Univ. Groningen 1972, 96 pp.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Teige, J., Nafstad, P.H.J. Ultrastructure of Colonic Epithelial Cells in Vitamin E and Selenium Deficient Pigs. Acta Vet Scand 19, 549–560 (1978). https://doi.org/10.1186/BF03547594
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1186/BF03547594