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Absence of Feeding-Induced Variations in Plasma Insulin in Hypoglycaemic-Ketonaemic Cows
Fravær av fórings-framkalte variasjoner i plasma insulin hos kyr med hypoglykemi og ketonemi
Acta Veterinaria Scandinavica volume 19, pages 215–228 (1978)
Abstract
The effects of food intake on plasma insulin levels were studied in 38 cows with plasma sugar ranging from 41 to 86 mg/100 ml and acetoacetate (Acac) ranging from 0.2 to 18 mg/100 ml, measured before morning feeding. The animals were fed concentrates, silage and hay. Blood samples were taken immediately before feeding in the morning and at intervals of % to 1 hr. during the following 4 hrs.
In animals with low blood Acac, plasma insulin concentrations began to increase as early as 1/2 hr. after the start of feeding and reached maxima after 2 hrs. Simultaneously Acac increased and sugar decreased markedly. Animals with Acac levels > 1 mg/100 ml had low pre-feeding insulin concentrations, and the level of the hormone did not increase after feeding. They did not show systematic changes in Acac. But plasma sugar tended to decrease when food was given, even in the absence of insulin increments in peripheral blood.
Glucose was infused at a low rate (0.9 g/min.) for 18 hrs. into a hypoglycaemic, ketonaemic cow. As her glucose and ketone levels became normalized, she also responded to feeding with insulin increments. But throughout the experiment her plasma insulin remained considerably lower than in an identically treated control animal which had low Acac levels before the infusion. It appears that the endocrine adjustments during ketonaemia in cows include, beside low basal (pre-feeding) insulin levels, an inhibition of the normally occurring elevation of plasma insulin after feeding.
Sammendrag
Virkningene av fóring på insulin i blodplasma ble studert hos 38 kyr med plasma sukker varierende fra 41 til 85 mg/100 ml og plasma acetoacetat (Acac) fra 0.2 til 18 mg/100 ml, ved måling før morgen- fóring. Alle dyrene ble fóret med kraftfór, silofór og h0y. Blodpr0ver ble tatt like før morgenfóring og med tidsintervall på 1/2 til 1 time i de fø1gende fire timer.
Hos individer med lave Acac-nivåer begynte plasma insulin å øke allerede 1/2 time etter fóring og nådde maksima etter omkring 2 timer. Samtidig økte Acac, og plasma sukker viste markert nedgang. Kyr med forhøyede Acac-verdier (> 1 mg/100 ml) og varierende grader av hypoglykemi hadde generelt lave insulinnivåer og hormonet viste ingen økning etter fóring. Heller ikke Acac forandret seg syste- matisk. Men en viss nedgang i plasma sukker etter fóring kunne på- vises, selv i fravær av insulin inkrement i perifert blod.
Evnen til å reagere på fóring med insulin inkrement ble restituert i 1øpet av en periode med langsom, kontinuerlig, intravenøs infusjon av glukose hos en hypoglykemisk-ketonemisk ku, samtidig med at ketonemien forsvant. Men under hele forsøket hadde den betydelig lavere plasmainsulin enn en likt behandlet kontrollku med lave ut- gangsverdier for Acac.
Den endokrine tilpasning til ketonemi hos kyr ser ut til å inn- befatte et lavt basalnivå (før fóring) av insulin og inhibisjon av den normalt forekommende økning i plasma insulin etter fóring.
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Hove, K., Halse, K. Absence of Feeding-Induced Variations in Plasma Insulin in Hypoglycaemic-Ketonaemic Cows. Acta Vet Scand 19, 215–228 (1978). https://doi.org/10.1186/BF03547627
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DOI: https://doi.org/10.1186/BF03547627