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Serum Glutathione Peroxidase Activity and Blood Selenium in Pigs

Serumgluiationperoxidas-aktivüet och blodselen hos grisar

Acta Veterinaria Scandinavica volume 19, pages 269–284 (1978)Cite this article

Abstract

Blood serum glutathione peroxidase activity and blood selenium concentration were measured in blood samples from pigs subjected to experimentally induced selenium deficiency and dietary selenium supplementation on graded levels. A highly significant correlation between blood selenium and serum GSH-Px activity in pigs, especially in selenium deficient pigs, was demonstrated. There was also a strong relationship between blood selenium concentration and serum GSH-Px activity in pigs receiving dietary selenium at graded levels. Serum GSH-Px activity exhibited an excellent close-response relationship to dietary selenium. Linear regression analysis showed that the increased serum GSH-Px activity was a function of the dietary selenium concentration. The fitness of serum in monitoring slight changes of the selenium status of pigs with help of the estimation of GSH-Px activity was discussed. The measurement of serum GSH-Px activity seems to provide a useful and rapid means for defining selenium requirements and for identifying selenium deficiency in growing pigs.

Sammanfattning

Blodserumglutationperoxidas-aktivitet och blodselenkoncentration mättes i blodprov från grisar vilka var utsatta för experimentellt in- ducerad selenbrist och dietär supplementering med selen på olika nivåer. Höggradigt signifikant korrelation mellan blodselen och serum GSH-Px aktivitet hos grisar, speciellt hos grisar utsatta för selenbrist, påvisades. Ett starkt samband konstaterades vidare föreligga mellan blodselenkoncentration och serum GSH-Px aktivitet hos grisar som fick selentillskott på olika nivåer i kosten. Höggradigt signifikant korrelation förelåg mellan serum GSH-Px aktivitet och dietärt intag av selen. Valet av serum vid glutationperoxidas-analyser för att avläsa grisens selenstatus diskuteras. Det fastslás att bestämning av serum- glutationperoxidas-aktivitet är en väl användbar och snabb metod för att fastställa selenbehov och att diagnostisera tillstånd av selen- brist hos växande grisar.

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Authors and Affiliations

  1. the Department of Animal Hygiene and the Department of Pathology, College of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden

    Juhani Hakkarainen, Paul Lindberg, Gösta Bengtsson & Lennart Jönsson

  2. the Department of Biochemistry, College of Veterinary Medicine, Helsinki, Finland

    Juhani Hakkarainen, Paul Lindberg, Gösta Bengtsson & Lennart Jönsson

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  1. Juhani Hakkarainen
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  2. Paul Lindberg
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  3. Gösta Bengtsson
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  4. Lennart Jönsson
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Hakkarainen, J., Lindberg, P., Bengtsson, G. et al. Serum Glutathione Peroxidase Activity and Blood Selenium in Pigs. Acta Vet Scand 19, 269–284 (1978). https://doi.org/10.1186/BF03547632

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Acta Veterinaria Scandinavica

ISSN: 1751-0147