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Experimental Infection with Mycobacterium Avium, Serotype 2, in Pigs

Infektionsforsøg på svin med Mycobacterium avium, Serotype 2: 4. Kontaktsmitte fra svin podet per os

4. Contact Infection from Orally Inoculated Pigs*

Acta Veterinaria Scandinavica volume 19, pages 58–72 (1978)Cite this article

Abstract

In 3 experiments, 13 pigs were inoculated orally with 0.5 mg Mycobacterium avium daily for 5 days (1 mg = 32–68×106 viable units). Five to 8 days after inoculation, 16 non-inoculated pigs were added to the inoculated pigs.

Cultures from faeces showed excretion of M. avium from all the inoculated pigs for some time within the period 16 to 65 days after the last inoculation; the greatest numbers of organisms (62000 per 100 g faeces) were found at about the middle of the excretion period (Table 2). Two of the contact pigs were found to excrete M. avium in small numbers, 1 at 15, the other at 37 and 44 days after contact.

All the inoculated pigs and 13 of the contact pigs showed positive intradermal tuberculin reactions. Post-mortem examination showed tuberculous lesions in all the inoculated pigs (Table 3). M. avium was transmitted to 15 of 16 pigs by contact. Five of these pigs showed gross lesions, 10 of them microscopic lesions only; in 9 of them the infection was proved by culture.

Sammendrag

I 3 eksperimenter blev ialt 13 grise podet peroralt med 0,5 mg M. avium daglig i 5 dage (1 mg = 32—68×106 bakterier).

Fem til 8 dage efter podningen blev 16 ikke-podede grise sat sammen med de podede.

Ved dyrkning fra gødningsprøver kom vækst af M. avium fra alle de podede grise. Udskillelsesperioden lå mellem 16. og 65. dag efter podningen, og den maksimale udskillelse (62000 bakterier pr. 100 g gødning) fandtes ca. midt i perioden (Tabel 2). To af kontaktgrisene viste udskillelse af M. avium i ringe antal, den ene gris 15. dag og den anden 37. og 44. dag efter kontaktsmittens begyndelse.

Post mortem undersøgelser viste, at alle de inficerede grise havde tuberkuløse forandringer.

Femten af 16 kontaktgrise viste tegn på smitteoverførsel enten ved tilstedeværelse af makroskopiske processer (5 grise) eller mikroskopiske processer (10 grise). Ni kontaktgrise var positive ved dyrkning.

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Authors and Affiliations

  1. The State Veterinary Serum Laboratory, Bülowsvej 27, DK-1870, Copenhagen V, Denmark

    J. Berg Jørgensen

  2. Tuberculosis Department, Statens Seruminstitut, Copenhagen, Denmark

    J. Berg Jørgensen

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  1. J. Berg Jørgensen
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Jørgensen, J.B. Experimental Infection with Mycobacterium Avium, Serotype 2, in Pigs. Acta Vet Scand 19, 58–72 (1978). https://doi.org/10.1186/BF03547642

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Acta Veterinaria Scandinavica

ISSN: 1751-0147