Skip to main content
Download PDF
  • Published:

Albumin Metabolism in Chronic Fasciola Hepatica Infections of Cattle

Albuminomsætning ved kronisk infektion med Fasciola hepatica hos kvæg

Acta Veterinaria Scandinavica volume 12, pages 335–343 (1971)Cite this article

Abstract

The metabolism of I131-albumin was examined in chronically fluke- infected animals in which anaemia and hypoalbuminaemia were prominent features. Animals with high fluke-burdens exhibited increased turnover rates of albumin, presumably due to a loss of blood into the bile ducts. Despite pronounced hepatic fibrosis the animals had a normal or only slightly decreased synthetic rate of albumin. This was in keeping with results from liver-function tests and is presumably explained by enlargement of the liver, resulting in maintenance of a near-normal parenchymal cell mass.

Sammendrag

Omsætningen af J131-albumin er undersøgt hos dyr med kronisk distomatose. Disse dyr havde udtalt anæmii og hypoalbuminæmi. Kraftigt inficerede dyr havde forøgede relative omsætningshastigheder af albumin, hvilket formentlig skyldtes et blodtab til galdegangene. Til trods for en udtalt hepatisk fibrose havde dyrene en normal eller kun let nedsat albumin syntese. Dette var i overensstemmelse med lever-funktionsprøver og kan antagelig forklares ved en forstørrelse af leveren, resulterende i en normal eller kun let formindsket masse af parenchymceller.

References

  • Dargie, J. D.: Pathophysiology of Fasciola hepática infections in rabbits. Thesis, Glasgow 1969.

    Google Scholar 

  • Dargie, J. D., P. H. Holmes, J. M. MacLean & W. Mulligan: Pathophysiology of fascioliasis in the rabbit. Studies on albumin turnover. J. comp. Path. 1968, 78, 101–105.

    Article  CAS  Google Scholar 

  • Dow, C, J. G. Ross & J. R. Todd: The pathology of experimental fascioliasis in calves. J. comp. Path. 1967, 77, 377–385.

    Article  CAS  Google Scholar 

  • Dow, C, J. G. Ross & J. R. Todd: The histopathology of Fasciola hepatica infections in sheep. Parasitology 1968, 58, 129–135.

    Article  CAS  Google Scholar 

  • Holmes, P. H., J. D. Dargie, J. M. MacLean & Mulligan: The anaemia in fascioliasis: Studies with 51Cr-labelled red cells. J. comp. Path. 1968a, 78, 415–420.

    Article  CAS  Google Scholar 

  • Holmes, P. H., J. D. Dargie, J. M. MacLean & W. Mulligan: Albumin and globulin turnover in chronic ovine fascioliasis. Vet. Rec. 1968 b, 83, 227–228.

    Article  CAS  Google Scholar 

  • Jennings, F. W., W, Mulligan & G. M. Urquhart: Radioisotope studies on the anemia produced by infection with Fasciola hepática. Exp. Parasit. 1956, 5, 458–468.

    Article  CAS  Google Scholar 

  • Keck, G. & R. Supperer: The changes occurring in the bileducts in chronic bovine fascioliasis. Vet. Med. Rev. 1967, No. 2/3, 322–329.

    Google Scholar 

  • Mancini, G., A. O. Carbonara & J. F. Heremans: Immunochemical quantitation of antigens by single radial immunodiffusion. Im-munochemistry 1965, 2, 235–254.

    CAS  Google Scholar 

  • McFarlane, A. S.: Efficient trace-labelling of proteins with iodine. Nature (Lond.) 1958, 182, 53.

    Article  CAS  Google Scholar 

  • Nansen, P.: Metabolism of bovine immunoglobulin-G. A clinical and pathophysiological study. Thesis, Copenhagen 1970.

    Google Scholar 

  • Nansen, P., L. Eriksen, M. G. Simesen & K. Nielsen: Chronic fascioliasis in sheep. II. Metabolism of 131I-labelled albumin and 125I-labelled immunoglobulin-G. Nord. Vet.-Med. 1968, 20, 651–656.

    Google Scholar 

  • Nieberle, K. & P. Cohrs: Lehrbuch der speziellen pathologischen Anatomie der Haustiere. (Textbook of special pathological anatomy of domestic animals). G. Fischer Verlag, 4th Ed., Jena 1961.

    Google Scholar 

  • Nielsen, K.: Gastrointestinal protein loss in cattle. A clinical and pathophysiological study. Thesis. Carl Fr. Mortensen, Copenhagen 1966.

    Google Scholar 

  • Nosslin, B.: In Applications of Tracer Theory of Protein Turnover Studies. J. nucl. Biol. Med. 1966, 10, 3–30.

    Google Scholar 

  • Pearson, I. G.: Use of the chromium radioisotope 51Cr to estimate blood loss through ingestion by Fasciola hepática. Exp. Parasit. 1963, 13, 186–193.

    Article  CAS  Google Scholar 

  • Rahko, T.: The pathology of natural Fasciola hepática infection in cattle. Path. Vet. 1969, 6, 244–256.

    CAS  Google Scholar 

  • Sewell, M. M. H., J. A. Hammond & D. C. Dinning: Studies on the aetiology of anaemia in chronic fascioliasis in sheep. Brit. vet. J. 1968, 124, 160–170.

    Article  CAS  Google Scholar 

  • Supperer, R.: Zum Wirt-Parasit-Verhältnis des grossen Leberegels, Fasciola hepática L. (The host-parasite relationship of Fasciola hepática). Dtsch. tierärztl. Wschr. 1964, 71, 668–670.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departement of Special Pathology and Therapeutics, Royal Veterinary and Agricultural University, Copenhagen, Denmark

    Peter Nansen

Authors
  1. Peter Nansen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nansen, P. Albumin Metabolism in Chronic Fasciola Hepatica Infections of Cattle. Acta Vet Scand 12, 335–343 (1971). https://doi.org/10.1186/BF03547734

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03547734

Acta Veterinaria Scandinavica

ISSN: 1751-0147