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Preliminary Experiments on Vaccination and Serum Treatment in the Prophylaxis of E. Coli O149:K91:H10 Infections in Newborn Piglets
Acta Veterinaria Scandinavica volume 12, pages 457–459 (1971)
Abstract
In a preliminary experiment two sows were vaccinated, respectively a fortnight and seven weeks before expected farrowing, with a vaccine consisting of equal parts of a suspension of E. coli strain A1 serotype O149:K91:H10 and Freund’s incomplete adjuvant, final concentration 5×109 organisms/ml, dose 4 ml, administered subcutaneously behind the ear. The vaccine gave rise to an immediate local reaction and left a fibrous nodule of walnut-size, but no systemic reaction was noticed. This agrees with experience from experimental work with vaccination of cows (Dam 1968) with a vaccine of the same composition, but representing the calf-pathogenic types of E. coli, and with experiences from the widespread use of vaccine of the same strength, but with the complete Freund adjuvant, in the prophylaxis of bovine colibacillosis in Belgium (Schoenaers & Kaeckenbeeck 1963). In none of these studies were systemic reactions ever observed.
References
Dam, A.: Prophylaxis of Coli septicaemia in calves by vaccination of the dams, serological and electrophoretical studies and calf-inoculation experiments. V. Int. Meet. Diseases Cattle. Opatija 1968, 247–253.
Dam, A.: Experimental infection of newborn piglets and weanling pigs with haemolytic E. coli, strain A1, serotype O149: K91:H10. Acta vet. scand. 1971, 12, 293–296.
Schoenaers, F. & A. Kaeckenbeeck: Études sur la colibacillose du veau. IV: Vaccination anticolibacillaire de la vache gestante. (Studies on Colibacillosis in calves. IV: Vaccination of the pregnant cow against E. coli). Ann. Méd. vét. 1963, 107, 529–543.
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Dam, A. Preliminary Experiments on Vaccination and Serum Treatment in the Prophylaxis of E. Coli O149:K91:H10 Infections in Newborn Piglets. Acta Vet Scand 12, 457–459 (1971). https://doi.org/10.1186/BF03547747
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DOI: https://doi.org/10.1186/BF03547747