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Ruminal Metabolism and Methemoglobin-Forming Effect of Dinobuton in Sheep
Acta Veterinaria Scandinavica volume 12, pages 300–302 (1971)
Abstract
Many aromatic nitro compounds are reduced to the corresponding amines in the rumen by the activity of the rumen flora, and this may influence the effect of such compounds when given orally to ruminants. The dinitrophenol herbicide DNBP (2-(1-methyl-n-propyl)-4,6-dinitrophenol, dinoseb) is a good example of a compound with this property, as DNBP has a methemoglobin-forming effect in ruminants (Frøslie & Karlog 1970). These authors connected this phenomenon with the ruminai metabolism of DNBP, because it is reduced to 6-ANBP (2-(1-methyl-n-propyl)-4-nitro-6-aminophenol), and 6-ANBP successively is reduced to DABP (2-(1-methyl-n-propyl)-4,6-diaminophenol) in the rumen.
References
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Fieser, L. F. & M. Fieser: Organic Chemistry. 3rd Ed., Reinhold, New York 1956, p. 178.
Frøslie, A.: The difference in methemoglobin formation by 6-amino metabolites of DNOC and DNBP in ruminant and nonruminant animals, with special references to sheep and swine. (In press).
Frøslie, A.: 1971. Not published.
Frøslie, A. & O. Karlog: Ruminai metabolism of DNOC and DNBP. Acta vet. scand. 1970, 11, 114–132.
Matsuo, H. & J. E. Casida: Photodegradation of two dinitrophenolic pesticide chemicals, dinobuton and dinoseb, applied to bean leaves. Bull, envir. Contain. Toxicol. 1970, 5, 72–78.
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Frøslie, A. Ruminal Metabolism and Methemoglobin-Forming Effect of Dinobuton in Sheep. Acta Vet Scand 12, 300–302 (1971). https://doi.org/10.1186/BF03547762
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DOI: https://doi.org/10.1186/BF03547762