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Clinical Biochemistry, Haematology and Body Weight in Piglets

Acta Veterinaria Scandinavica volume 39, pages 381–393 (1998)Cite this article

Abstract

Reference ranges for clinical biochemical parameters commonly investigated in pigs were determined in one- (day 1), 21- and 35-day old piglets. The mean and standard deviation were also estimated for body weight, and haematological and clinical biochemical parameters at these ages. The piglets were divided into 2 investigation groups according to whether they had a haemoglobin concentration ≤ 80 g/1 (“anaemic group”) or > 80 g/1 (“normal group”) on days 14,21 and 28. The “anaemic group” was compared to the “normal group” on days 21 and 35. Many of the clinical biochemical parameters varied according to age. Some of the enzymes had high average values and wide reference ranges in piglets, especially on day 1, compared to the reference ranges for sows given in the literature. The refer-ence ranges for some of the metabolic parameters were broader on day 1 than later in the preweaning period. The reference ranges for albumin, total iron-binding capacity and serum iron were, however, lower and more narrow on day 1. On days 21 and 35, rel-atively high values for phosphorus must be considered “normal” compared to the fig-ures given in the literature for adult pigs. The other minerals seemed to be quite unaf-fected of age, but some were affected by anaemia. The anaemic piglets had lower average serum iron but higher total iron-binding capacity than the “normal” piglets on days 21 and 35. However, variation between piglets gave wide reference ranges, indi-cating that these parameters will only have limited usefulness in detecting iron defi-ciency anaemia in piglets. The electrolytes seemed also to be affected by the existence of anaemia. The body weight and leukocyte counts were significantly lower in the “anaemic group” than the “normal group” on day 35, while the greatest differences in clinical biochemical parameters between the groups were found on day 21, when the piglets in the “anaemic group” were most severely anaemic. Although these piglets suf-fered from severe iron-deficiency anaemia, only a few clinical biochemical parameters were affected, and the differences between groups were mostly small.

References

  • Agricultural Research Council: The nutrient requirements of farm livestock. London. 1967, Pigs.

  • Baustad B: Forsek med perorale jerntilskudd til smågris. (Studies on peroral iron supplementation in piglets). Medlemsbl. norske Veterinaer Foren. 1969, 21, 253–262. (In Norwegian).

    CAS  Google Scholar 

  • Bengtsson G, Gentz J, Hakkarainen J, Hellström R, Persson B: Plasma levels of FEA, glycerol, ß-hy-droxybutyrate and blood glucose during the postnatal development of the pig. J. Nutr. 1969, 97, 311–315.

    Article  CAS  PubMed  Google Scholar 

  • Brenner KV, Gürtler H: Die Konzentration an Kortisol, Glukose und freien Fettsäuren im Blutplasma bei Schweinen in Abhängigkeit vom Alter sowie bei Sauen im Zeitraum der Geburt. (Concentrations of cortisone, glucose, and free fatty acids in blood plasma of swine, depending on age, and in sows close to farrowing.) Arch. exp. Vet.-Med. 1977, 31, 741–747.

    CAS  Google Scholar 

  • Carlson GP: Fluid, electrolyte, and acid-base balance. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, California. 1989, 543–575.

    Google Scholar 

  • Coalson JA, Maxwell CV, Hillier JC, Washam RD, Nelson EC: Calcium and phosphorus requirements of young pigs reared under controlled environmental conditions. J. Anim. Sci. 1972, 35, 1194–1200.

    Article  CAS  PubMed  Google Scholar 

  • Coulter DB, Swenson MJ: Plasmatic and erythrocytic electrolytes in irondeficiency anemia of pigs (SUS SCROFA). Comp. Biochem. Physiol. 1973, 44A, 461–466.

    Article  Google Scholar 

  • Dallman PR: Biochemical basis for the manifestations of iron deficiency Ann. Rev. Nutr. 1986, 6, 13–40.

    Article  CAS  Google Scholar 

  • Egeli AK: Iron deficiency anaemia in piglets. PhD thesis, Norwegian College of Veterinary Medicine, Oslo, Norway. 1998.

    Google Scholar 

  • Egeli AK, Framstad T: Evaluation of the efficacy of perorally administered glutamic acid-chelated iron and irondextran injected subcutaneously in Duroc and Norwegian Landrace piglets. J Vet. Med. A, 1998a, 45, 1–000

    Article  Google Scholar 

  • Egeli AK, Framstad T: Effect of an oral starter dose of iron on haematology and weight gain in piglets having voluntary access to glutamic acid-chelated iron solution. Acta vet. scand. 1998b.

    Google Scholar 

  • Egeli AK, Framstad T, Gronningen D: The effect of peroral administration of amino acid-chelated iron to pregnant sows in preventing sow and piglet anaemia. Acta Vet. Scand. 1998c, 39, 1.

    Google Scholar 

  • Farver TB: Concepts of normality in clinical bio-chemistry. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, 1989, 1–20.

    Google Scholar 

  • Framstad T, Sjaastad OV, Aass R: Blodprovetaking på gris. (Blood sampling in pigs) Norsk Vet.-T. 1988. 100, 265–273. (In Norwegian).

    Google Scholar 

  • Framstad T, Havre GN, Morberg H: Effekt av lagring, separering og heparin på klinisk-kjemiske analyseresultater av griseblod. (The effect of storage, separation and use of heparin on the clinical biochemical analysis of pig blood) Norsk Vet.-T. 1989. 101, 237–243. (In Norwegian).

    Google Scholar 

  • Framstad T, Morberg H, Aass RA: Klinisk-kjemiske analyser av griseblod. Referanseomrâder for purker. (Clinical biochemical analyses of pig blood. Reference ranges for sows) Norsk Vet.-T. 1991, 103, 807–815. (In Norwegian).

    Google Scholar 

  • Friendship RM, Lumsden JH, McMillan I, Wilson MR: Hematology and biochemistry reference values for Ontario swine. Canad. J. comp. Med. 1984, 48, 390–393.

    CAS  Google Scholar 

  • Furugouri K: Characteristic aspects of iron metabolism in piglets. Jap. agric. Res. Q. 1975, 9, 171–176.

    CAS  Google Scholar 

  • Gainer JH, Guarnieri J, Das NK: Neutropenia and anemia in the iron deficient baby pig. Calif. Vet. 1985, I, 18–41.

    Google Scholar 

  • Glawischnig Von E, Schierica G, Schuller W, Baumgartner W: Arbeitswerte in der laboratoriumsdi-agnostik beim schwein. (Working values for laboratory diagnosis in pigs.) Wien, tierärztl. Mschr. 1977, 64, 341–346.

    CAS  Google Scholar 

  • Groth Von W, Kalchreuter S, Hahn R: Die Einflüsse der Rasse, des Alters, der Jahreszeit und der Umstallung in die Besamungsstation auf Enzymaktivitäten, Mineralstoff- und Harnstoffkonzentratione im Blutplasma von Besamungsebern. (Influence of breed, age, season and change of housing on enzyme activity, and mineral and urea concentrations in blood plasma of boars) 1 Teil. Tierärztl. Umsch. 1986, 41, 652–658.

    Google Scholar 

  • Groth Von W, Kalchreuter S, Hahn R: Die Einflüsse der Rasse, des Alters, der Jahreszeit und der Umstallung in die Besamungsstation auf Enzymaktivitäten, Mineralstoff- und Harnstoffkonzentratione im Blutplasma von Besamungsebern. (Influence of breed, age, season and change of housing on enzyme activity, and mineral and urea concentrations in blood plasma of boars) Teil 2. Tierärztl Umsch. 1986, 41, 778–787.

    Google Scholar 

  • Grün Von E, U Ix: Serumenzyme bei neugeborenen Tieren. 2. Mitt: Verhalten bei neugeborenen Ferkeln. (Serum enzymes in new-born animals. 2nd communication: Behaviour in new-born piglets.) Mh. Vet.-Med. 1973, 28, 705–712.

    Google Scholar 

  • Harvey JW: The erythrocyte: Physiology, Metabolism, and Biochemical Disorders. In: Kaneko JJ, Harvey JW, Bruss ML (ed.) Clinical biochemistry of domestic animals. 5th ed. Academic Press. San Diego, 1997, 157–203.

    Chapter  Google Scholar 

  • Kaneko JJ: Appendix VII: Normal blood analysis values in large animals. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, California. 1989, 886–891.

    Google Scholar 

  • Kaneko JJ: Serum proteins and the dysproteinemias. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, 1989, 142–165.

    Google Scholar 

  • Kramer JW: Clinical enzymology. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, 1989, 338–363.

    Google Scholar 

  • Ku PK, Miller ER, Ullrey DE: Effect of parenteral iron on serum electrolytes of the baby pig. J. Anim. Sci. 1983, 57, 638–644.

    Article  CAS  PubMed  Google Scholar 

  • Lumsden JH, Mullen K: On establishing reference values. Canad. J. comp. Med. 1978, 42, 293–301.

    CAS  Google Scholar 

  • McClellan RO, Vogt GS, Ragan HA: Age-related changes in hematological and serum biochemical parameters in miniature swine. In: Swine in biomedical research. Frayn printing, Seattle. 1966, 597–610.

    Google Scholar 

  • Mersmann HJ, Arakelian MC, Brown LI: Plasma lipids in neonatal and growing swine. J. Anim. Sci. 1979, 48, 554–558.

    Article  CAS  PubMed  Google Scholar 

  • Miller ER, Ullrey DE, Zutaut CL, Betty, Baltzer V, Schmidt DA, Hoefer JA, Luecke RW: Phosphorus requirement of the baby pig. J. Nutr. 1964, &2, 34–40.

    Article  Google Scholar 

  • Reese DE, Peo ER, Lewis AJ, Hogg A: Serum chemical values of gestating and lactating swine: Reference values. Amer. J. Vet. Res. 1984, 45, 978–980.

    CAS  PubMed  Google Scholar 

  • Schierica Von G, Köfer J, Baumgartner W, Schuh M: Verlaufsuntersuchungen über die Blutgase und den Säure-Basen-Haushalt mit Bestimmung von Hämoglobin und Hämatokrit bei Ferkeln. (Follow up studies on blood gases, acid-base-relationship, hemoglobin and hematocrit in blood from piglets. 2nd communication: phase from birth to weaning.) Dtsch. Tierärztl. Wschr. 1981, 88, 50–53.

    Google Scholar 

  • Smith JE: Iron metabolism and its diseases. In: Kaneko JJ (ed.) Clinical biochemistry of domestic animals. 4th ed. Academic Press. San Diego, 1989, 256–273.

    Google Scholar 

  • Tewes H, Steinbach J, Smidt D: Investigations on the blood composition of sows during the reproductive cycle. II. Blood changes during pregnancy. Zuchthyg. 1979, 14, 111–116.

    Article  CAS  Google Scholar 

  • Tewes H, Steinbach J, Smidt D: Investigations on the blood composition of sows during the reproductive cycle. Blood changes during lactation. Zuchthyg. 1979, 14, 111–116.

    Article  CAS  Google Scholar 

  • Tollersrud S, Baustad B: Serum enzyme activity of new-born calves, pigs, and lambs. Acta Vet. Scand. 1970, 11, 525–535.

    CAS  PubMed  Google Scholar 

  • Tumbleson ME, Hutcheson DP, Fogg TJ: Serum bio-chemical values of fetal and neonatal crossbred swine. Technicon International Congress (1970, New York) Advances in automated analysis. Futura Pub. Co, Mount Kisco, New York. 1972, 149–156.

    Google Scholar 

  • Tumbleson ME, Schmidt DA, Scholl E: Hematology and clinical chemistry. In Diseases of swine. A.D. Leman (ed.) 6th ed. Ames, Iowa, The Iowa State University Press. 1986, 27–44.

    Google Scholar 

  • Ullrey DE, Miller ER, Brent BE, Bradley BL, Hoefer JA: Swine hematology from birth to maturity. IV Serum calcium, magnesium, sodium, potassium, copper, zink and inorganic phosphorus. J. Anim. Sci. 1967, 25, 1024–1029.

    Article  Google Scholar 

  • van Kempen GJM: Avoid iron deficiency in piglets. Pigs. 1987, 3, 10–11.

    Google Scholar 

  • Venn JAJ, McCance RA, Widdowson EM: Iron metabolism in piglet anaemia. J. comp. Path. 1947, 57, 314–325.

    Article  CAS  Google Scholar 

  • Wilson GDA, Harvey DG, Snook CR: A review of factors affecting blood biochemistry in the pig. Brit. Vet. J. 1972, 128, 596–609.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

The authors wish to thank the staff of the Central Laboratory, Department of Physiology, Biochemistry and Nutrition, Norwegian College of Veterinary Medicine for technical assistance.

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Authors and Affiliations

  1. Department of Reproduction and Forensic Medicine, Norwegian College of Veterinary Medicine, POB. 8146, N-0033, Oslo, Norway

    A. K. Egeli & T. Framstad

  2. Department of Biochemistry, Physiology and Nutri-tion, Central Laboratory, Norwegian College of Veterinary Medicine, POB. 8146, Dep. N-0033, Oslo, Norway

    H. Morberg

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  1. A. K. Egeli
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  2. T. Framstad
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  3. H. Morberg
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Correspondence to A. K. Egeli.

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Egeli, A.K., Framstad, T. & Morberg, H. Clinical Biochemistry, Haematology and Body Weight in Piglets. Acta Vet Scand 39, 381–393 (1998). https://doi.org/10.1186/BF03547786

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Acta Veterinaria Scandinavica

ISSN: 1751-0147