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Control of Caprine Arthritis-Encephalitis Virus and Corynebacterium Pseudotuberculosis Infection in a Norwegian Goat Herd

Bekjempelse av caprint artritt-encefalitt virus og Corynebacterium pseudotuberculosis infeksjon i en norsk geitebesetning

Acta Veterinaria Scandinavica volume 39, pages 109–117 (1998)Cite this article

Abstract

A control programme for caprine arthritis-encephalitis virus (CAEV) and Corynebacterium pseudotuberculosis (C. pseudotuberculosis) infection was established in a Norwegian goat herd comprising approximately 100 milking goats. The herd seroprevalences of antibodies against CAEV and C. pseudotuberculosis were 97% and 94%, respectively.

Kids were removed from the infected flock at birth, avoiding any contact between dam and kid. The kids were kept completely segregated from the seropositive flock and fed cow's colostrum and milk. A seronegative flock was established, based on the removed kids and their offspring. Goats belonging to the seronegative flock were allowed to kid naturally and to mother their kids. The seropositive flock was slaughtered during the second year of the control programme. After washing and disinfection, housing systems and nearby outdoor premises were left empty for 3 months.

Of 230 goats examined for antibodies against CAEV with ELISA regularly during 3 years of the control program, altogether 6 were found to be seropositive, while for 10 the result was indeterminate. All 16 animals were immediately culled. During the third year of the control programme, all goats were examined and proved negative for antibodies against C. pseudotuberculosis by a haemolysis inhibition test. Clinical examination revealed no signs of CAE or caseous lymphadenitis. kw|Keywords|k]control programme; k]ELISA; k]haemolysis inhibition test

Sammendrag

Et kontrollprogram for caprint artritt-encefalitt virus (CAEV) og Corynebacterium pseudotuberculosis (C. pseudotuberculsois) infeksjon ble etablert i en norsk geitebesetning med ca. 100 melkegeiter. Forekomsten av antistoffer mot CAEV og C. pseudotuberculosis i besetningen var 97% og 94%. Kjeene ble fjernet fra den infiserte flokken umiddelbart etter fødsel. All kontakt mellom mor og avkom ble forhindret. Kjeene ble holdt helt atskilt fra den infiserte flokken og alet opp på kumelk. En seronegativ flokk ble etablert, basert på disse kjeene og deres avkom. Geiter som tilhørte den seronegative flokken fikk kjee naturlig og amme kjeene sine. Den seropositive flokken ble slaktet i løpet av det andre året av kontrollprogrammet. Etter vasking og desinfeksjon, ble husdyrrom og nærliggende utearealer holdt fri for dyr i tre måneder.

Av 230 geiter som ble undersøkt for antistoffer mot CAEV med ELISA i løpet av 3 års kontrollprogram, ble 6 funnet seropositive, og 10 hadde ubestemmelig resultat. Alle 16 dyr ble tatt ut av flokken umiddelbart. Det tredje året ble alle geitene i kontrollprogrammet undersøkt og funnet negative for antistoffer mot C. pseudotuberculosis i synergistisk antihemolysin test. Det ble ikke funnet tegn til CAE eller byllesjuke ved klinisk undersøkelse.

References

  • Adams DS, Klevjer AP, Carlson JL, McGuire TC, Gorham JR: Transmission and control of caprine arthritis-encephalitis virus. Am. J. vet. Res., 1983,44, 1670–5.

    Google Scholar 

  • Adams DS, Oliver RE, Ameghino E, Demariini JC, Verwoerd DW, Houwers DJ, Waghela S, Gorham JR, Hyllseth B, Dawson M, Trigo FJ, McGuire TC: Global survey of serological evidence of caprine arthritis-encephalitis virus infection. Vet. Ree, 1984,775, 493–5.

    Google Scholar 

  • Addo PB: Pathology and bacteriology of abortion in sheep experimentally infected with Corynebacte-rium pseudotuberculosis. Bull. Anim. Hlth. Prod. Afr., 1979,27, 257–262.

    Google Scholar 

  • Anderson VM, Nairn ME: Control of caseous lymphadenitis in goats by vaccination. In: Le maladies de la chevre. Niort, 1984, Les colloques de l'inra, 28, 605–609.

    Google Scholar 

  • Ashfaq MK, Campbell SG: A survey of caseous lymphadenitis and its etiology in goats in the United States. Vet. Med., 1979, 74, 1161–1165.

    Google Scholar 

  • Augustine JL, Renshaw HW: Survival of Corynebac-terium pseudotuberculosis in axenic purulent exudate on common barnyard fomites. Am. J.vet. Res., 1986,47, 713–715.

    Google Scholar 

  • Brown CC, Olander HJ: Caseous lymphadenitis of goats and sheep: A review. Vet. Bull. 1989, 57, 1–12.

    Google Scholar 

  • Bulgin MS: Ovine progressive pneumonia, caprine arthritis-encephalitis, and related lentiviral diseases of sheep and goats. Vet. Clin. North Am. Food Anim. Pract, 1990, 6, 691–704.

    Article  Google Scholar 

  • Dawson M: Caprine arthritis-encephalitis. In Practice: Farm Pract., 1987, 8–11.

    Google Scholar 

  • Dercksen DP, ter Laak EA, Schreuder BEC: Eradication programme for caseous lymphadenitis in goats in the Netherlands. Vet. Ree, 1996, 138, 237.

    Article  Google Scholar 

  • East NE, Rowe JD, Dahlberg JE, Theilen GH, Pedersen NC: Modes of transmission of caprine arthritis-encephalitis virus infection. Small rumin. Res., 1993, 70,251–262.

    Google Scholar 

  • Ellis T: Control of caprine arthritis-encephalitis in goats. J. Agric, West. Aust., 1988,29, 91–95.

    Google Scholar 

  • Ellis T, Robinson W, Wilcox G: Effect of colostrum deprivation of goat kids on the natural transmission of caprine retrovirus. Aust. vet. J., 1983, 60, 326–329.

    Article  Google Scholar 

  • Ellis TM: “Big knee” virus of goats. Agric. Farm-note, West. Aust. Dept., 1985, 60(85) 15–17.

    Google Scholar 

  • Fenner F, Bachmann PA, Gibbs EPJ, Murphy FA, Studdert MJ, White DO: Veterinary Virology. London: Academic Press, 1987.

    Google Scholar 

  • Halgaard C: Det frivillige maedi-visna kontrolpro-gram. (Voluntary maedi/visna control programme). Dan. vet. Tidsskr., 1988, 77, 198–202.

    Google Scholar 

  • Holstad G: Corynebacterium pseudotuberculosis in goats, II. The prevalence of caseous lymphadenitis in 36 goat herds in northern Norway. Acta vet. scand., 1986a, 27, 584–597.

    Article  Google Scholar 

  • Holstad G: Corynebacterium pseudotuberculosis infection in goats, V Relationships between the infection and lesions resulting from vaccination against paratuberculosis. Acta vet. scand., 1986b, 27, 617–622.

    Article  Google Scholar 

  • Holstad G: Corynebacterium pseudotuberculosis infection in goats, I. Evaluation of two serological diagnostic tests. Acta vet. scand., 1986c, 27, 575–583.

    Article  Google Scholar 

  • Holstad G: Corynebacterium pseudotuberculosis infection in goats, IV Course of the infection in two recently infected goat herds. Acta vet. scand., 1986d, 27, 609–616.

    Article  Google Scholar 

  • Holstad G, Teige J, Larsen HJ: Corynebacterium pseudotuberculosis infection in goats VIII. The effect of vaccination against experimental infection. Acta vet. scand., 1989, 30, 275–283.

    Article  Google Scholar 

  • Holstad G: Corynebacterium pseudotuberculosis infection in goats, IX. The effect of vaccination against natural infection. Acta vet. scand., 1989, 30, 285–293.

    Article  Google Scholar 

  • MacDiarmid SC: Scheme to accredit flocks free from caprine arthritis encephalitis infection. N. Z. vet. J., 1984, 32, 165–66.

    Article  Google Scholar 

  • MacKenzie RW, Oliver RE, Rooney JP, Kagei H: A successful attempt to raise goat kids free of infection with caprine arthritis encephalitis virus in an endemically infected goat herd. N. Z. vet. J., 1987,35, 184–86.

    Article  Google Scholar 

  • McGuire TC, O'Rourke KI, Knowles DP, Cheevers WP: Caprine arthritis encephalitis lentivirus transmission and disease. Curr. Top. Microbiol. Immunol., 1990,160, 61–75.

    Google Scholar 

  • Narayan O, Clements JE, Strandberg, JD, Cork LC, Griffin DE: Biological characterization of the virus causing leukoencephalomyelitis and arthritis in goats. J. gen. Virol., 1980, 50, 69–79.

    Article  Google Scholar 

  • Narayan O, Wolinsky JS, Clements JS, Strandberg JD, Griffin DE, Cork LC: Slow virus replication: the role of macrophages in the persistence and expression of visna viruses of sheep and goats. J. gen. Virol., 1982, 59, 345–356.

    Article  Google Scholar 

  • Regli J, Ruff G, Zanoni R: Impact of CAE disease and practical experience in CAE sanitation in Switzerland. Toulouse: 41st annual meeting of the European Association for Animal Production, Session IV, 1985, (Commision on sheep and goat production, Animal management and health, Slow-virus-diseases in sheep and goats).

  • Rimstad E, East N, Derock E, Higgins J, Pedersen NC: Detection of antibodies to caprine arthritis-encephalitis virus using recombinant GAG proteins. Arch. Virol., 1994,134, 345–356.

    Article  Google Scholar 

  • Rimstad E, East NE, Torten M, Higgins J, Derock E, Pedersen NC: Delayed Seroconversion following Naturally Acquired Caprine Arthritis-Encephalitis Virus Infection in Goats. Amer. J. vet. Res., 1993, 54, 1858–1862.

    Google Scholar 

  • Robinson WF, Ellis TM: Caprine arthritis-encephalitis virus infection: from recognition to eradication. Aust. vet. J., 1986, 63, 237–241.

    Article  Google Scholar 

  • Rowe JD, East NE, Franti CE, Thurmond MC, Pedersen NC, Theilen GH: Risk factors associated with the incidence of seroconversion to caprine arthritis-encephalitis virus in goats on California dairies. Amer. J. vet. Res., 1992a, 53, 2396–403.

    Google Scholar 

  • Rowe JD, East NE, Thurmond MC, Fränti CE, Pedersen NC: Cohort study of natural transmission and two methods for control of caprine arthritis-encephalitis virus infection in goats on a California dairy. Amer. J. vet. Res., 1992b, 53, 2386–95.

    Google Scholar 

  • Schreuder BEC, ter Laak EA, Dercksen DP: Eradication of caseous lymphadenitis in sheep with the help of a newly developed ELISA technique. Vet. Ree, 1994,135, 174–176.

    Article  Google Scholar 

  • Smith MC, Cutlip R: Effects of infection with caprine arthritis-encephalitis virus on milk production in goats. J. Amer. vet. med. Ass. 1988,193, 63–7.

    Google Scholar 

  • Woodard JC, Gaskin JM, Poulos PW, MacKay RJ, Burridge MJ: Caprine arthritis-encephalitis: cli-nicopathologic study. Amer. J. vet. Res., 1982, 43, 2085–96.

    Google Scholar 

  • Zink MC, Narayan O: Lentivirus-induced interferon inhibits maturation and proliferation of monocytes and restricts the replication of caprine arthritis-encephalitis virus. J. Virol., 1989, 63, 2578–84.

    Article  Google Scholar 

  • Zwahlen R, Aeschbacher M, Balcer T: Lentivirusin-fectionen bei Ziegen mit Carpitis und interstitieller Mastitis. (Lentivirusinfection in Goats with Carpitis and interstitial Mastitis). Schweiz. Arch. Tierheilk., 1983,125, 281–299.

    Google Scholar 

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Acknowledgments

We wish to thank Dr. A. Storset for kindly blood-sampling and testing the infected animals by virus isolation. We are grateful to Professor S.A. Oedegaard for performing caesarian sections, and to District Veterinary Officer J.G. Noersteboe for clinical examinations and sampling. Thanks are also due to Anne Berit Hvaal for serological examinations for C. pseudotuberculosis.

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Authors and Affiliations

  1. Department of Large Animal Clinical Sciences, Norwegian College of Veterinary Medicine, 0033, Oslo, Norway

    K. Nord & K Grønstøl

  2. Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway

    G. Holstad

  3. Department of Animal Science, Agricultural University of Norway, Aas, Norway

    L.O. Eik

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  1. K. Nord
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  2. G. Holstad
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Nord, K., Holstad, G., Eik, L. et al. Control of Caprine Arthritis-Encephalitis Virus and Corynebacterium Pseudotuberculosis Infection in a Norwegian Goat Herd. Acta Vet Scand 39, 109–117 (1998). https://doi.org/10.1186/BF03547812

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Acta Veterinaria Scandinavica

ISSN: 1751-0147