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Fate of Ingested Histamine in Sheep
II. Faecal and Urinary Excretion
Acta Veterinaria Scandinavica volume 8, pages 176–183 (1967)
Abstract
When histamine was given by mouth to sheep, the urinary increase in free and conjugated histamine on an average corresponded to 0.016 and 0.52 % of the administered dose, respectively. Between 4 and 18 % of C14-histamine given by mouth was recovered as radioactivity in the urine.
Free and conjugated histamine was only occasionally detected in faeces after oral loading with histamine diphosphate, and the quantities were small. Following oral administration of C14-histamine 2.4—11.2 % of the administered radioactivity was excreted with faeces. This study gave no clue to explain the fate of the radioactivity not excreted by faeces or urine.
References
Bergstrøm, S. & G. Hansson: The use of Amberlite IRC-50 for the purification of adrenaline and histamine. Acta physiol. scand. 1951, 22, 87–92.
Halpern, B. N., Th. Neveu & C. W. M. Wilson: The distribution and fate of radioactive histamine in the rat. J. Physiol. (Lond.) 1959, 147, 437–449.
Schauer, R. W.: The metabolism of ring-labeled histamine. J. biol. Chem. 1952, 196, 469–475.
Sjaastad, Ø. V.: Determination and occurrence of histamine in rumen liquor of sheep. Acta vet. scand. 1967 a, 8, 50–70.
Sjaastad, Ø. V.: Fate of ingested histamine in sheep. I. Disappearance from the rumen. Acta vet. scand. 1967 b, 8, 157–175.
Sjaastad, Ø. V.: Determination and occurrence of free and conjugated histamine in urine of sheep. 1967 c. In preparation.
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Sjaastad, Ø.V. Fate of Ingested Histamine in Sheep. Acta Vet Scand 8, 176–183 (1967). https://doi.org/10.1186/BF03547842
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DOI: https://doi.org/10.1186/BF03547842