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Fate of Ingested Histamine in Sheep

II. Faecal and Urinary Excretion


When histamine was given by mouth to sheep, the urinary increase in free and conjugated histamine on an average corresponded to 0.016 and 0.52 % of the administered dose, respectively. Between 4 and 18 % of C14-histamine given by mouth was recovered as radioactivity in the urine.

Free and conjugated histamine was only occasionally detected in faeces after oral loading with histamine diphosphate, and the quantities were small. Following oral administration of C14-histamine 2.4—11.2 % of the administered radioactivity was excreted with faeces. This study gave no clue to explain the fate of the radioactivity not excreted by faeces or urine.


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Sjaastad, Ø.V. Fate of Ingested Histamine in Sheep. Acta Vet Scand 8, 176–183 (1967).

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