Sensitivity of Suckling Mice to Various Strains of Infectious Bronchitis Virus
Acta Veterinaria Scandinavica volume 8, pages 86–87 (1967)
Suckling mice are serviceable in many virological experiments because they are sensitive to various virus species. Simpson & Groupé (2) succeeded in adapting the Beaudette strain of infectious bronchitis virus (IBV) to suckling mice, using the intracerebral route of inoculation. A study of the properties of a Finnish strain of infectious bronchitis virus (IBVF) has been published recently (1). It successfully established the intracerebral adaptation of IBVF to suckling mice. The suckling mice were 100 % sensitive to this virus strain up to an age of 12 days. Symptoms of the central nervous system with a typical clearly discernible gibbosity in the vertebral column were elicited after an incubation period of 2—3 days, and the animals died 3—4 days after the inoculation. Parallelly with IBVF, transmission experiments with other IBV strains were carried out. The present paper is a report on the results of these experiments.
Estola, T.: Studies on the infectious bronchitis virus of chickens isolated in Finland with reference to the serological survey of its occurrence. Acta vet. scand. 1966, suppl. 18.
Simpson, A. W. & V. Groupé: Temperature of incubation as a critical factor in the behavior of avian bronchitis virus in chicken embryos. Virology 1959, 8, 456–469.
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Estola, T. Sensitivity of Suckling Mice to Various Strains of Infectious Bronchitis Virus. Acta Vet Scand 8, 86–87 (1967). https://doi.org/10.1186/BF03547856