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The Influence of a »Flushing Dose« of Selenium on the Excretion of Selenium in Sheep
Acta Veterinaria Scandinavica volume 9, pages 199–207 (1968)
Summary
The influence of injected selenium on the excretion of radioactive selenium stored in the body was studied in 4 male sheep. At the beginning of the experiment, radioactive selenium as Se75-sodium selenite and Se75-L-selenomethionine was injected subcutaneously, each compound in 2 rams. The injection of Se75-sodium selenite was repeated in one ram after 37 days. Non-radioactive selenium as sodium selenite or DL-selenomethionine was injected between 5 and 47 days after the injection of the Se75-dose. Each injection of non-radioactive sodium selenite increased the urinary Se75-excretion on an average 10 times. A close correlation was demonstrated between the concentration of Se75 and total selenium in urine.
After the subcutaneous injection of Se75-L-selenomethionine the Se75-excretion in urine was increased both with a “flushing dose” of sodium selenite and with DL-selenomethionine. The concentration of Se75 and that of total selenium in urine of these animals were closely correlated.
Se75-excretion in feces was not markedly influenced by the administration of non-radioactive selenium.
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Jacobsson, S.O., Lindberg, P. The Influence of a »Flushing Dose« of Selenium on the Excretion of Selenium in Sheep. Acta Vet Scand 9, 199–207 (1968). https://doi.org/10.1186/BF03547867
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DOI: https://doi.org/10.1186/BF03547867