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The Pathology of Vinyl Chloride Exposed Mice

Acta Veterinaria Scandinavica volume 17, pages 328–342 (1976)Cite this article

Abstract

Outbred albino laboratory mice were exposed to 50 p.p.m. and 500 p.p.m. vinyl chloride by inhalation 6 hrs./day, 5 days/week during 52 and 26 weeks, respectively. Pathologic examination showed the presence of histologically benign alveologenic lung adenomas, haem-angiosarcomas in fat tissue as well as a few benign and malignant tumours at various sites. Only one liver haemangiosarcoma was noted. All animals exposed to 500 p.p.m. developed tumours; 71 % of the animals given 50 p.p.m. were tumour bearing. The frequency of all tumours, number of tumour foci and size of foci in both groups suggest a dose-dependent carcinogenic effect of vinyl chloride. Haemocoelia due to blood vessel rupture was a common cause of death. Telangiectasis of the liver was also observed in a few animals. The role of fat tissue as well as blood vessel involvement in the pathology of vinyl chloride is discussed.

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Acknowledgment

The authors are indebted to Alna Ekner, Annika Eriksson, Ella Jensen, Ulla Hammarström and Gun Lindkvist for technical assistance and to Inge Ericsson for preparing photographs.

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Authors and Affiliations

  1. Section of Occupational Toxicology, National Board of Occupational Safety and Health, Stockholm, and the National Veterinary Institute, Stockholm, Sweden

    B. Holmberg (assoc. professor), T. Kronevi & M. Winell

  2. National Board of Occupational Safety and Health, P. O. Box S-100 26, Stockholm, Sweden

    B. Holmberg (assoc. professor), T. Kronevi & M. Winell

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  1. B. Holmberg
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  2. T. Kronevi
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  3. M. Winell
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Holmberg, B., Kronevi, T. & Winell, M. The Pathology of Vinyl Chloride Exposed Mice. Acta Vet Scand 17, 328–342 (1976). https://doi.org/10.1186/BF03547913

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Acta Veterinaria Scandinavica

ISSN: 1751-0147