Skip to main content
Download PDF
  • Published:

Tryptophan Metabolism in Pigs

Tryptofanomsætningezi hos svin: Relation til syntese og funktion af serotonin

Relation to Synthesis and Function of Serotonin

Acta Veterinaria Scandinavica volume 17, pages 113–130 (1976)Cite this article

Abstract

Contrary to blood serotonin the level of free and total tryptophan is distinctly influenced by feed intensity and composition. Piglets show a considerably higher plasma free tryptophan and blood serotonin content than adult pigs, just as boars possess a significantly higher blood level of tryptophan and serotonin than sows. A pronounced individual variation of blood serotonin and a much less variable content among littermate pigs provide evidence that blood serotonin is genetically controlled. Tryptophan is readily absorbed and distributed in a characteristic manner among investigated organs and tissues. A genetical control of blood serotonin and its possible relation with type of reaction exhibited by ergometer exercised pigs support the influence of tryptophan and serotonin on the ability of pigs to withstand controlled environmental conditions such as physical exercise.

Sammendrag

Effekten af såvel ydre som genetiske faktorer på blodets Trp- og 5-HT-indhold er undersøgt hos Dansk Landrace svin.

Ved tilførsel af mærket (3H-Trp) og ikke mærket Trp er endvidere undersøgt tryptofans resorption, transport, fordeling samt relation til serotoninsyntesen.

Plasmaets indhoid af fri og total Trp er i modsætning til blodets 5-HT markant påvirkelig af næringstilførselens omfang og sammensætning. Unge grise viste et væsentligt høj ere plasma fri Trp og blod 5-HT indhold end voksne grise, ligesom kønsmodne orner besidder et signifikant højere Trp- og 5-HT-indhold i blodet end sogrise. En betydelig mindre variation af blod 5-HT indenfor kuld end mellem disse tyder på en genetisk kontrol af blodets 5-HT-indhold.

Trp optages hurtigt fra svinets tarmkanal og fordeles på en karakteristisk måde mellem de undersøgte væv og organer. Resultaterne af Trp-belastningen tyder på en nær relation mellem tryptofan- og serotoninomsætningen hos svin.

Den genetiske kontrol af blodets 5-HT-indhold samt dettes sammenhæng med grises reaktion på ergometerbelastning synes at understrege tryptofans og Serotonins betydning for grises adaptationsevne under disse betingelser.

References

  • Biber, B., J. Fara & O. Lundgren: Intestinal vascular responses to 5-hydroxytryptamine. Acta physiol, scand. 1973, 87, 526–534.

  • Bligh, J., W. H. Cottle & M. Maskreg: Influence of ambient temperature on the thermoregulatory responses to 5-hydroxytryptamine, noradrenaline and acetylcholine injected into the lateral cerebral ventricles of sheep, goats and rabbits. J. Physiol. (Lond.) 1971, 212, 377–392.

  • Bouillon, D. J. & R. A. O’Brien: Abnormalities of 5-hydroxytryptamine uptake and binding by blood platelets from children with Down’s syndrome. J. Physiol. (Lond.) 1971, 212, 287–297.

  • Brummerstedt-Hansen, E.: The Serum Proteins in the Pig. An Immunoelectrophoretic Study. Thesis, Munksgaard, Copenhagen 1967.

    Google Scholar 

  • Boyum, A.: Separation of leucocytes from blood and bone marrow. Scand. J. clin. Lab. Invest. 1968, 21, suppl. 97.

    Google Scholar 

  • Candlish, E., N. E. Stanger, T. J. Devlin & L. J. La Croix: Tryptophan absorption and metabolism in sheep. Canad. J. Anim. Sci. 1970, 50, 337–344.

  • Cassens, R. G., D. N. Marple & G. Eikelenboom: Animal physiology and meat quality. In Advances in Food Research. C. O. Chichester et al., eds. Vol. 21, p. 71, Acad. Press, N. Y. 1975.

    Article  CAS  Google Scholar 

  • Ciaranello, R. D., A. Lipsky & J. Axelrod: Association between fighting behaviour ard catecholamine biosynthetic enzyme activity in two inbred mouse sublines. Proc. nat. Acad. Sci. (Wash.) 1974, 71, 3006–3008.

  • Collu, R., F. Fraschini, P. Visconti & L. Martini: Adrenergic and serotonergic control of growth hormone secretion in adult male rats. Endocrinology 1972, 90, 1231–1237.

  • Crawford, N.: Serotonin absorption by normal and “carcinoid” platelets. Glin. chim. Acta 1967, 18, 297–307.

  • Curzon, G., B. D. Kantamaneni, J. Winch, A. Rojas-Bueno, I. M. Murray-Lyon & R. Williams: Plasma and brain tryptophan changes in experimental acute hepatic failure. J. Neurochem. 1973, 21, 137–145.

  • Denckla, W. D. & H. K. Dewey: The determination of tryptophan in plasma, liver and urine. J. Lab. clin. Med. 1967, 69, 160–169.

  • Eleftheriou, B. E. & D. W. Bailey: A gene controlling plasma serotonin levels in mice. J. Endocr. 1972, 55, 225–226.

  • Erspamer, V.: Pharmacology of indolealkylamines. Pharmacol. Rev. 1954, 6, 425–444.

  • Feldberg, W. & R. D. Myers: A new concept of temperature regulation of amines in the hypothalamus. Nature (Lond.) 1963, 200, 1325.

    Article  CAS  Google Scholar 

  • Fuxe, K., J. Schubert, T. Hökfelt & G. Jonsson: Some aspects of the interrelationship between central 5-hydroxytryptamine neurons and hormones. Adv. biochem. Psychopharmacol. 1974, 11, 67–74.

  • Heikkinen, E. S.: Inactivation of 5-hydroxytryptamine in rats. Acta physiol, scand. 1968. Suppl. 311, p. 7–82.

  • Holmsen, H. & H. J. Day: The selectivity of the trombin-induced platelet release reaction. J. Lab. clin. Med. 1970, 75, 840–844.

  • Imura, H., Y. Nakai & T. Yoshimi: Effect of 5-hydroxytryptophan (5-HTP) on growth hormone and AGTH release in man. J. clin. Endocr. 1973, 36, 204–206.

  • Meyer, D. C., P. D. Sturkie & K. Gross: Diurnal rhythm in serotonin of blood and pineals of chickens. Comp. Biochem. Physiol. 1973, 46A, 619–623.

  • Murphy, D. L., J. R. Mendell & W. K, Engel: Serotonin and platelet function in Duchenne Muscular Dystrophy. Arch. Neurol. (Ghic.) 1973, 28, 239–243.

  • Neckers, L. & P. Y. Sze: Regulation of 5-hydroxytryptamine metabolism in mouse brain by adrenal glucocorticoids. Brain Res. 1975, 93, 123–132.

  • Page, I. H.: Serotonin (5-hydroxytryptamine). Physiol. Rev. 1954, 34, 563–587.

  • Page, I, H.: Serotonin. Year Book Medical Publ., Chicago 1968.

  • Rastogi, R. B. & R. L. Singhal: Thyroid hormone control of 5-hydroxytryptamine metabolism in developing rat brain. J. Pharmacol, exp. Ther. 1974, 191, 72–81.

  • Sneddon, J. M.: Platelet Serotonin. In Progress in Neurobiology. Kerkut, G. A. & J. W. Phillis, eds. Vol. 1, pp. 151–198, Pergamon Press, Oxford 1973.

  • Tagliamonte, A., G. Biggio, L. Vargiu & G. L, Gessa: Free tryptophan in serum controls brain tryptophan level and serotonin synthesis. Life Sci. 1973, 12, 277–287.

  • Thierry, Anne-Marie, M. Fekete & J. Glowinski: Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5-HT) in the central nervous system of the rat. II. Modifications of serotonin metabolism. Europ. J. Pharmacol. 1968, 4, 384–389.

  • Topel, D. G., D, G. Wilson, G. M. Weiss & L. L. Christian: Influence of phenoxybenzamine and propanolol on blood serotonin and pH, plasma cortisol and M. longissimus pH and color in swine. J. Animal Sci. 1973, 36, 1077–1080.

  • Tschopp, T. B. & M. B. Zucker: Hereditary defect in platelet function in rats. Blood 1972, 40, 217–226.

  • Vermes, L., G. Dull, G. Telegdy & K. Lissak: Possible role of serotonin in the monosamine induced inhibition of the stress mechanism in the rat. Acta physiol. Acad. Sci. hung. 1972, 42, 219–223.

  • Weiss, H. J., T. B. Tschopp, J. Bogers & H. Brand: Studies of platelet 5-hydroxytryptamine (serotonin) in storage pool disease and albinism. J. clin. Invest. 1974, 54, 421–432.

  • Went, M. & B. Csaba: Effect of cortisone treatment and adrenalectomy on 5-hydroxytryptophan decarboxylase and monoamino oxidase activity in mouse tissues. Acta physiol. Acad. Sci. hung. 1973, 43, 233–237.

  • Wurtman, B. J. & J. D. Fernstrom: L-tryptophan, L-tyrosine, and the control of brain monoamine biosynthesis. In Perspectives in Neuropharmacology. S. H. Snyder, ed. Oxford Univ. Press 1972, p. 143.

    Google Scholar 

  • Wurtman, B. J., C. M. Bose, C. Chou & F. Larin: Daily rhythms in the concentrations of various amino acids in human plasma. New. Engl. J. Med. 1968, 279, 171–175.

  • Vuwiler, A., S. Plotkin, E. Geller & E. B. Brrvo: A rapid accurate procedure for the determination of serotonin in whole human blood. Biochem. Med. 1970, 3, 426–436.

Download references

Acknowledgment

The authors wish to address their gratitude to Professor, dr. med. vet. Johs. Moustgaard on whose initiative the present work was undertaken. For valuable assistance during the work we wish to thank dr. Birthe Palludan.

Author information

Authors and Affiliations

  1. Department of Physiology, Endocrinology and Bloodgrouping, Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870, Copenhagen V, Denmark

    J. Hyldgaard-Jensen & Inger Wegger

  2. Institute for the Application of Nuclear Energy in Agriculture, Veterinary Medicine and Forestry, Zemun, Yugoslavia, Serbia

    R. Cmiljanić

  3. Clinic for Surgery, Veterinary Faculty, University of Belgrade, Yugoslavia, Serbia

    R. Andrić

Authors
  1. J. Hyldgaard-Jensen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Cmiljanić
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Inger Wegger
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. R. Andrić
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hyldgaard-Jensen, J., Cmiljanić, R., Wegger, I. et al. Tryptophan Metabolism in Pigs. Acta Vet Scand 17, 113–130 (1976). https://doi.org/10.1186/BF03547921

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03547921

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147