Skip to main content
Download PDF
  • Published:

Hematological and Biochemical Analyses of Blood and Serum in Pigs with Regional Ileitis with Special Reference to the Pathogenesis

Hematologisk och biokemisk analys au blod och serum från grisar med regional ileit med särskild hänsyn till patogenesen

Acta Veterinaria Scandinavica volume 17, pages 233–243 (1976)Cite this article

Abstract

Biochemical and hematological analyses of blood and serum were performed in pigs with regional ileitis and in wasting pigs with a negative necropsy. In sera from pigs with regional ileitis the levels of total protein, albumin, transferrin, alkaline phosphatase and zinc were significantly decreased compared with normal pigs of the same age. The number of white blood cells, and the concentration of Cortisol and α1-antitrypsin were significantly increased. In wasting pigs with early signs of regional ileitis or with a negative necropsy the same blood changes were observed but to a less degree. It was concluded that a wasting syndrome after weaning may precede regional ileitis. Concerning the etiology of regional ileitis the significance of malabsorption and wasting syndrome in combination with invasion of intestinal intercellular microorganisms is discussed.

Sammanfattning

Analysen av serum och blod från grisar med regional ileit och från s.k. „Pellar“ med negativ sektion har utförts. I serum från fall av regional ileit påvisades en signifikant minskad halt av totalprotein, albumin, alkaliskt fosfatas och zink. Antalet vita blodkroppar samt halten Cortisol och α1-antitrypsin var signifikant ökad. I serum från s.k. „Pellar“ med antingen negativ sektion eller i mycket tidigt stadium av regional ileit påvisades samma avvikelser som dock var mindre uttalade. Ett „wasting syndrome“ (Pelleutseende) efter avvänjning anses predisponera för uppkomsten av regional ileit. Angående etiologin till regional ileit diskuteras betydelsen av malabsorption och „wasting syndrome“ i kombination med invasion av intracellulära mikroorganismer i epitelet av ileum.

References

  • Agergaard, N. & B. Palludan: Zinkomsætningen hos svin. VII. Alkalisk fosfataseaktivitet i plasma og væv i relation til zinkstatus. (Zinc metabolism in swine. VII. Alkaline phosphatase activity in plasma and tissues in relation to zinc status). Aarsberetn. Inst. Sterilitetsforskn. 1974, p. 47–59, A/S Carl F. Mortensen, Copenhagen.

  • Burch, R. E., R. V. Williams, H. K. J. Hahn, M. M. Jeton & J. F. Sullivan: Serum and tissue enzyme activity and trace-element content in response to zinc deficiency in the pig. Clin. Chern. 1975, 21, 568–578.

  • Dodd, D. C.: Adenomatous intestinal hyperplasia (proliferative ileitis) of swine. Path. Vet. 1968, 5, 333–341.

  • Forster, G.: In Methoden der enzymatischen Analyse. Ed. by H. U. Bergmeyer, 2. Auflage, 1970, p. 755.

    Google Scholar 

  • Glock, R. D.: The pathogenesis of swine dysentry. Proc. Int. vet. Pig Soc., Hannover 1972, p. 62.

    Google Scholar 

  • Huang, T. C., C. P. Chem, V. Wefler & A. Raftery: A stable reagent for Lieberman-Burchard reaction applied to rapid serum cholesterol determination. Analyt. Chem. 1961, 33, 1405–1411.

  • Jönsson, L. & K. Martinsson: Regional ileitis in pigs. Morphological and pathogenetical aspects. Acta vet. scand. 1976, 17, 223–232.

  • Kenworthy, R. & W. D. Allen: The significance of E. coli to the young pig. J. comp. Path. 1966, 76, 31–44.

  • Kenworthy, R., J. M. Stubbs & G. Syme: Ultrastructure of small-intestinal epithelium in weaned and unweaned pigs with postweaning diarrhoea. J. Path. Bact. 1967, 93, 493–498.

  • Laurell, C.-B.: Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies. Analyt. Biochem. 1966, 15, 45–52.

  • Lawson, G. H. K. & A. C. Rowland: Intestinal adenomatosis in the pig: Abacteriological study. Res. Vet. Sci. 1974, 17, 331–336.

  • Martinsson, K. & K. Carlstrom: The analogues of human α1-antitrypsin, α2-macroglobulin and pregnancy zone protein (PZ) in swine with some aspects of pregnancy diagnosis. Zbl. Vet.-Med. 1976. In press.

    Google Scholar 

  • Martinsson, K. &. L. Ekman: Behandlingsförsök avseende s.k. pellar bland avvanda grisar. (Experiments of treating wasting pigs after weaning with zinc). Svensk Vet.-Tidn. 1974, 24, 824–828.

  • Martinsson, K., N. Holmgren, L. Jönsson & G. Nordström: Några under-sbkningar over terminal ileit hos grisar. (Some investigations on terminal ileitis in pigs). Svensk Vet.-Tidn. 1974, 10, 347–354.

  • Mukasa, H., S. Kajiyama, K. Sugiyama, K. Funakubo, M. Itoh, Y. Nosoh & T. Sato: The subunit structure of porcine ceruloplasmin. Biochim. biophys. Acta (Amst.) 1968, 168, 132–142.

  • Nielsen, K.: Metabolism and distribution of I131-labelled albumin in pigs with gastrointestinal disease. Acta vet. scand. 1966, 7, 321–329.

  • Nielsen, K.: Regional enteritis in domestic animals. Regional enteritis (Grohn’s disease). Ed. by Engel & Larsson, Stockholm 1971.

    Google Scholar 

  • Parisi, A. F. & B. L. Wallee: Isolation of a zinc α2-macroglobulin from human serum. Biochemistry 1970, 9, 2421–2428.

  • Platt, B. S. & W. Frankul: The influence of a low-protein diet on the level of zinc and iron in the serum and liver of the pig. Proc. Nutr. Soc. 1962, 21, VII—VIII.

  • Prasad, A. S., D. Oberleas & P. Wolf: Changes in trace elements and enzyme activities in tissue of zinc deficient pig. Amer. J. clin. Nutr. 1969, 22, 628–638.

  • Richkind, M. & L. E. Edqvist: Peripheral plasma levels of corticosteroids in normal beagles and greyhounds measured by a rapid competitive protein binding technique. Acta vet. scand. 1973, 14, 745–757.

  • Rowland, A. C. & P. G. M. Rowntree: A hemorrhagic bowel syndrome associated with intestinal adenomatosis in the pig. Vet. Rec. 1972, 91, 235–241.

  • Rowland, A. C. & G. H. K. Lawson: Intestinal adenomatosis in the pig: Immunofluorescent and electron microscopic studies. Res. Vet. Sci. 1974, 17, 323–330.

  • Scandinavian Committee on Enzymes: Recommended methods for the determination of four enzymes in blood. Scand. J. clin. Lab. Invest. 1974, 33, 291–295.

  • Taylor, D. J. & W. F. Blakemore: Spirochaetal invasion of the colonic epithelium in swine dysentery. Res. Vet. Sci. 1971, 12, 177–179.

  • Thoron-Tolling, K. & K. Martinsson: On the transferrin concentration in serum of sows and growing pigs and in sow colostrum. Acta vet. scand. 1974, 15, 120–134.

Download references

Author information

Authors and Affiliations

  1. the Department of Medicine I, the Department of Clinical Biochemistry and the Department of Pathology, Royal Veterinary College, S-104 05, Stockholm 50, Sweden

    Κjell Martinsson, Lars Ekman & Lennart Jönsson

Authors
  1. Κjell Martinsson
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Lars Ekman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Lennart Jönsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Martinsson, Κ., Ekman, L. & Jönsson, L. Hematological and Biochemical Analyses of Blood and Serum in Pigs with Regional Ileitis with Special Reference to the Pathogenesis. Acta Vet Scand 17, 233–243 (1976). https://doi.org/10.1186/BF03547931

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03547931

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147