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Differences in Renal Clearances Measured in Danish Pigs

Forskelle i renale clearances målt på danske svin

Acta Veterinaria Scandinavica volume 11, pages 443–451 (1970)Cite this article

Abstract

Measurements are reported of renal clearances of inulin, endogenous creatinine, urea and PAH in 15 pigs in order to elucidate (a) the effect of pentobarbitone and urethane on the renal clearances, (b) differences in clearances measured by continuous infusion and by subcutaneous injection, (c) the effect of the intensity of feeding on the renal clearances, and (d) the difference in the renal clearances between two strains of Danish Landrace pigs.

Sedation with pentobarbitone and urethane had no effect on the renal clearances of the pigs. Measurement of clearances by continuous infusion gave the same results as use of the subcutaneous injection method. Changes in the intensity of feeding and the consequent effect on growth had no influence on the renal clearances or on the relative kidney weight. Considerable differences were demonstrated in the renal function of pigs from two different strains of Danish Landrace Pigs.

Sammendrag

Der er udført renale clearance undersøgelser omfattende clearance for inulin, endogen kreatinin, urinstof og PAH på 15 svin til belysning af: a) mebumal og uretans indflydelse på de renale clearances, b) forskelle i clearances målt ved henholdsvis kontinuerlig infusion og ved subkutan injektion, c) fodringsintensitetens indflydelse på de renale clearances og d) forskellen i de renale clearances mellem to grise-stammer indenfor Dansk Landrace.

Beroligelse med mebumal og uretan påvirkede ikke de renale clearances hos svin. Glearancemålinger udført med kontinuerlig infusion gav samme resultater som ved anvendelse af subkutan injektion. Ændret fodringsintensitet og dermed ændret tilvækst påvirkede hverken de renale clearances, eller den relative nyrevægt. Der påvistes betydelige forskelle i nyrefunktionen hos grise fra to forskellige grise-stammer indenfor Dansk Landrace.

References

  • Bonsnes, R. W. & H. H. Taussky: On the colorimetric determination of creatinine by the Jaffe reaction. J. biol. Chem. 1945, 158, 581–591.

    CAS  Google Scholar 

  • Bratton, A. C. & E. K. Marshall: A new coupling component for sulfanilamide determination. J. biol. Chem. 1939, 128, 537–550.

    CAS  Google Scholar 

  • Brun, C: In Iversen, P., T. Bjering & J. Bing: De medicinske nyre-lidelser. (Medical renal disease). 2. udg., K0benhavn 1946, p. 83-85.

  • Conway, E. J.: Microdiffusion analysis and volumetric error. 3rd Ed., London 1950, p. 152.

    Google Scholar 

  • Corcoran, A. C. & I. H. Page: Effects of anesthetic dosage of pentobarbital sodium on renal function and blood pressure in dogs. Amer. J. Physiol. 1943, 140, 234–239.

    Article  CAS  Google Scholar 

  • Dalgaard-Mikkelsen, S., E. Poulsen & B. Simesen: Sulfadimidin og sulfatiazol til ungsvin. (Fate of sulfamezathine and sulpha-thiazole in young pigs). Nord. Vet.-Med. 1953, 5, 965–981.

    Google Scholar 

  • Deutsch, S., E. C. Pierce jr. & L. D. Yandam: Cyclopropane effects on renal function in normal man. Anesthesiology 1967, 28, 547–558.

    Article  CAS  Google Scholar 

  • Dupré, J. & R. V. Coxon: Use of subcutaneous depots of test substances in the measurement of renal clearances. Quart. J. exp. Physiol. 1958, 43, 74–85.

    Article  Google Scholar 

  • Gilmore, J. P. & L. L. Michaelis: Influence of anesthesia on renal responses of the foxhound to intravascular volume expansion. Amer. J. Physiol. 1969, 216, 1367–1369.

    Article  CAS  Google Scholar 

  • Glauser, K. F. & E. E. Selkurt: Effect of barbiturates on renal function in the dog. Amer. J. Physiol. 1952, 168, 469–479.

    Article  CAS  Google Scholar 

  • Gyrd-Hansen, N.: Renal clearances in pigs. Acta vet. scand. 1968, 9, 183–198.

    CAS  Google Scholar 

  • Gyrd-Hansen, N.: The effects of diuretics on renal clearances in pigs. Acta vet. scand. 1969, 10, 345–358.

    CAS  PubMed  Google Scholar 

  • Habif, D. V., E. M. Papper, H. F. Fitzpatrick, P. Lowrance, C. McC. Smythe & S. E. Bradley: The renal and hepatic blood flow, glomerular filtration rate, and urinary output of electrolytes during cyclopropane, ether, and thiopental anesthesia, operation, and the immediate postoperative period. Surgery 1951, 30, 241–255.

    CAS  PubMed  Google Scholar 

  • Lassen, J. B. & O. E. Nielsen: Investigations into the diuretic effect and elimination of triamterene. Acta pharmacol. (Kbh.) 1963, 20, 309–316.

    Article  CAS  Google Scholar 

  • Nielsen, O. E.: Den renale kaliumudskillelse. (The renal excretion of potassium). Thesis. K0benhavn 1968, p. 33–44.

    Google Scholar 

  • Papper, S. & E. M. Papper: The effects of preanesthetic, anesthetic, and postoperative drugs on renal function. Clin. Pharmacol. Ther. 1964, 5, 205–215.

    Article  CAS  Google Scholar 

  • Ramsay, D. J. & R. V. Coxon: The effect of intravenously infused saline on the renal clearances of inulin and para-aminohippurate in dogs. Quart. J. exp. Physiol. 1967, 52, 145–149.

    Article  CAS  Google Scholar 

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  1. Institute of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Copenhagen, Denmark

    N. Gyrd-Hansen

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Gyrd-Hansen, N. Differences in Renal Clearances Measured in Danish Pigs. Acta Vet Scand 11, 443–451 (1970). https://doi.org/10.1186/BF03547970

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Acta Veterinaria Scandinavica

ISSN: 1751-0147