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Determination and Occurrence of Free and Conjugated Histamine in Urine of Sheep

Bestemmelse og forekomst av fri og konjugert histamin i urin fra sau (får)

Acta Veterinaria Scandinavica volume 11, pages 305–317 (1970)Cite this article

Abstract

  1. 1.

    By modifying the method of Duriér & Pernow (1956) the urinary excretion of free and conjugated histamine was examined in 11 healthy adult sheep.

  2. 2.

    The mean excretion of free histamine was 9.8 ± 9.0 (s) µg base/24 hrs. (uncorrected for losses during extraction). When individual means were used, the range was: 2.1–34.2 µg base/24 hrs. The intraindividual variations were of the same order as the interindividual variations.

  3. 3.

    The mean excretion of conjugated histamine was equivalent to 15.1 ± 9.9 (s) µg histamine base/24 hrs. In all animals the ratio conjugated/free histamine was above 1. The interindividual as well as the intraindividual variation for conjugated histamine was of the same order as for free histamine.

Sammendrag

  1. 1.

    Utskillelsen av fri og konjugert histamin med urinen hos 11 voksne, normale sauer ble undersøkt med en metode etter Dunér & Pernow (1956) noe modifisert.

  2. 2.

    Ekskresjonen av fritt histamin var i middel 9.8 ± 9.0 (s) µg base/24 timer (ukorrigert for tap under ekstraksjonen). De individuelle middelverdier varierte fra 2.1 til 34.2 µg base/24 timer. De intraindividuelle og de interindividuelle variasjoner var av samme størrelsesorden.

  3. 3.

    Utskillelsen av konjugert histamin var i middel ekvivalent med 15.1 ± 9.9 (s) µg histamin-base/24 timer. Hos alle dyr var kvotienten konjugert/fri histamin større enn 1. Både de intra- og interindividuelle variasjoner for konjugert histamin var av samme størrelsesorden som for fri histamin.

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Acknowledgments

The technical assistance of Mrs. Solvaar Eliassen is highly appreciated.

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  1. Department of Physiology, Veterinary College of Norway, Oslo, Norway

    Ø. V. Sjaastad

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Sjaastad, Ø.V. Determination and Occurrence of Free and Conjugated Histamine in Urine of Sheep. Acta Vet Scand 11, 305–317 (1970). https://doi.org/10.1186/BF03547990

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Acta Veterinaria Scandinavica

ISSN: 1751-0147