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Some Effects of Protein Deficiency in Young Growing Pigs. II. Blood Plasma Free Amino Acids

Acta Veterinaria Scandinavica volume 11, pages 1–15 (1970)Cite this article

Summary

The influence of protein deficiency, rehabilitation and total starvation on the free amino acid levels in the blood plasma of pigs has been investigated. It was found that the concentration of most amino acids was reduced during protein deficiency. The levels of leucine, isoleucine and valine were diminished by the greatest proportion, followed by threonine, tyrosine and citrulline. During the first few weeks of protein deficiency the levels of lysine, histidine and arginine were slightly increased, but later decreased below control values. Concentrations of glycine and alanine were altered in a similar way except that the initial increase was much more pronounced. The concentrations of most of these amino acids returned to control levels after rehabilitation. Total starvation led to an increase in concentration of leucine, isoleucine, valine, threonine and to a smaller extent phenylalanine, lysine, citrulline and arginine. The concentration of glycine, alanine and glutamic acid were very much reduced. The level of urea in the circulation dropped reversibly during protein deficiency and increased very much during total starvation.

References

  • Allison, J. B., R. W. Wannemacher Jr., & W. L. Banks: Influence of dietary protein on protein biosynthesis in various tissues. Fed. Proc. 1963, 22, 1126–1130.

    CAS  PubMed  Google Scholar 

  • Cuperlovic, M., M. Jovanovic & D. Stosic: Free amino acids in the blood plasma of pigs during total starvation. In Isotope Studies on the Nitrogen Chain. International Atomic Energy Agency, Vienna 1968, 193–208.

    Google Scholar 

  • Cuperlovic, M. & D. Stosit: Protein metabolism in monogastric animals connected with their requirements for essential limiting amino acids. Institute for Application of Nuclear Energy in Agriculture, Veterinary Medicine and Forestry, Zemun, Yugoslavia. Ann. rep. Project no. E-30-AH-6, 1968.

    Google Scholar 

  • Elwyn, D. H.: Modification of plasma amino acids patterns by the liver. In Protein Nutrition and Free Amino Acid Patterns, ed. J. H. Leathern, Rutgers Univ. Press, New Rrunswick, New Jersey 1968, 88–107.

    Google Scholar 

  • Fajans, S. S., J. C. Floyd Jr., R. F. Knopf & J. W. Conn: Effect of amino acids and protein on insulin secretion in man. Recent Progr. Hormone Res. 1967, 23, 617–662.

    CAS  PubMed  Google Scholar 

  • Fallon, H. J., J. L. Davis & R. A. Goyer: Effect of protein intake on tissue amino acid levels and the enzymes of serin biosynthesis in the rat. J. Nutr. 1968, 96, 220–226.

    Article  CAS  Google Scholar 

  • Holt, L. E., S. E. Snyderman, P. M. Norton, E. Roitman & J. Finch: The plasma aminogram in kwashiorkor. Lancet 1963, II, 1343–1348.

    Article  Google Scholar 

  • Holt, L. E., S. E. Snyderman, P. M. Norton & E. Roitman: The plasma aminogram as affected by protein intake. In Protein Nutrition and Free Amino Acid Patterns, ed. J. H. Leathern, Rutgers Univ. Press, New Brunswick, New Jersey 1968, 32–40.

    Google Scholar 

  • Lindquist, B.: Hydrolysis of proteins for amino acid determination. In Methods for Determination of Amino Acid Composition of Milk Proteins, ed. K. Brunfeldt, Danish Institute of Protein Chemistry, Copenhagen 1966, 7–15.

    Google Scholar 

  • Luyken, R., N. A. Pikaar, P. Slump, T. Dohle & R. Schrender: Serum amino acids and low-protein diet. Lancet 1966, I, 1213.

    Article  Google Scholar 

  • McMenamy, R. H., W. C. Shoemaker, J. E. Richmond & D. Ehvyn: Uptake and metabolism of amino acids by the dog liver perfused in situ. Amer. J. Physiol. 1962, 202, 407–414.

    CAS  Google Scholar 

  • Mihailovic, M., B. Nikolic, O. Pavlovic, M. Vukotic, M. Cuperlovic & D. Stosic: The effect of total starvation on body weight and some blood components. Yugosl. physiol, pharmacol. Acta 1967, 3, 342–345.

    CAS  Google Scholar 

  • Miller, L. L.: The role of liver and nonhepatic tissues in the regulation of free amino acid levels in the blood. In Amino Acid Pools, ed. J. T. Holden, New York, Elsevier 1962, 708–721.

    Google Scholar 

  • Mimura, T., C. Jamada & Marian E. Swendseid: Influence of dietary protein levels and hydrocortisone administration on the bran- ched-chain amino acid transaminase activity in rat tissues. J. Nutr. 1968, 95, 493–497.

    Article  CAS  Google Scholar 

  • Nikolic, J. A., M. Cuperlovic & D. Stosic: Some effects of protein deficiency in young growing pigs. I. The serum protein system. Acta vet. scand. 1969, 10, 382–401.

    Article  CAS  Google Scholar 

  • Pimstone, B., G. Barbezat, J. D. L. Hansen & P. Murray: Growth hormone and protein calorie malnutrition. Lancet 1967, II, 1333–1334.

    Article  Google Scholar 

  • Saunders, S. J., A. S. Truswell, G. O. Barbezat, W. Wittman & J. D. L. Hansen: Plasma free amino acid pattern in protein calorie malnutrition. Lancet 1967, II, 795–797.

    Article  Google Scholar 

  • Scharff, R. & J. G. Wool: Effect of diabetes on the concentration of amino acids in plasma and heart muscle of rats. Biochem. J. 1966, 99, 173–178.

    Article  CAS  Google Scholar 

  • Stein, W. H. & S. Moore: The free amino acids of human blood plasma. J. biol. Chem. 1954, 211, 915–926.

    Article  CAS  Google Scholar 

  • Swendseid, M. E., S. G. Tuttle, W. S. Figueroa, D. Mulcare, A. J. Clark & F. J. Massey: Plasma amino acid levels of men fed diets differing in protein content. Some observations with valine deficient diets. J. Nutr. 1966, 88, 239–248.

    Article  CAS  Google Scholar 

  • Whitehead, R. G.: Hydroxyproline creatinine ratio as an index of nutritional status and rate of growth. Lancet 1965, II, 567–570.

    Article  Google Scholar 

  • Widdowson, E. M. & R. G. Whitehead: Plasma amino acid ratios and urinary hydroxyproline excretion in rats deficient in protein and calories. Nature (Lond.) 1966, 212, 683–686.

    Article  CAS  Google Scholar 

  • Young, V. R. & N. S. Schrimshaw: Endogenous nitrogen metabolism and plasma free amino acids in young adults given a “protein- free” diet. Brit. J. Nutr. 1968, 22, 9–20.

    Article  CAS  Google Scholar 

  • Zimmermann-Telschow, H.: Die Veranderung der freien Aminosauren im Nuchernblut in Abhangigkeit von der Ernahrung beim Men- schen. 2. Ernahrungsversuche mit Milchprotein. (Changes in free amino acids in fasting human blood in relation to diet. 2. Trials with milk protein). Nutr. et Dieta (Basel) 1965, 7, 37–50.

    CAS  Google Scholar 

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Acknowledgment

The authors wish to thank Professor J. Moustgaard, Royal Veterinary and Agricultural University, Copenhagen, Denmark, for advice and helpful discussions and Zdenka Boban for skilled technical assistance.

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Authors and Affiliations

  1. The Institute for the Application of Nuclear Energy in Agriculture, Veterinary Medicine and Forestry, Zemun, Yugoslavia, Serbia

    M. Cuperlovié & D. Stosié

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  1. M. Cuperlovié
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  2. D. Stosié
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Cuperlovié, M., Stosié, D. Some Effects of Protein Deficiency in Young Growing Pigs. II. Blood Plasma Free Amino Acids. Acta Vet Scand 11, 1–15 (1970). https://doi.org/10.1186/BF03547999

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Acta Veterinaria Scandinavica

ISSN: 1751-0147