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Histopathological Changes in Canine Allergic Contact Dermatitis Patch Test Reactions

A study on spontaneously hypersensitive dogs

Acta Veterinaria Scandinavica volume 30, pages 379–384 (1989)Cite this article

Abstract

The histopathology of allergic patch test reactions in dogs with spontaneous allergic contact dermatitis (ACD) was investigated. Epidermal necrosis was present in half of the biopsies and neutrophilic granulocytes were present within epidermis in these biopsies as well as in some of the biopsies without necrosis. Spongiosis was only occasionally observed.

Dermal infiltration with neutrophilic granulocytes and oedema was found in all biopsies while the number of lymphocytes was small.

The results may indicate a different secretion of or responsiveness towards cytokines in canine ACD compared to ACD in man where epidermal necrosis is not a characteristic feature and where the predominant inflammatory cell is the lymphocyte.

It is anticipated that histopathological investigation of patch test reactions in dogs will not be helpful in discriminating between allergic and toxic patch test reactions.

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Acknowledgments

The inspiration and allergological expertise provided for by Dr. Flemming Kristensen, Dept. of Small Animal Diseases, Royal Veterinary and Agricultural University, is gratefully acknowledged by the authors.

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Authors and Affiliations

  1. Dept. of Pharmacology Leo Pharmaceutical Products, Ballerup and Dept. of Pathology, Bispebjerg Hospital, Copenhagen, Denmark

    Mads Krogsgaard Thomsen & Henrik Klem Thomsen

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  1. Mads Krogsgaard Thomsen
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  2. Henrik Klem Thomsen
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Thomsen, M.K., Thomsen, H.K. Histopathological Changes in Canine Allergic Contact Dermatitis Patch Test Reactions. Acta Vet Scand 30, 379–384 (1989). https://doi.org/10.1186/BF03548013

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Acta Veterinaria Scandinavica

ISSN: 1751-0147