Corynebacterium Pseudotuberculosis Infection in Goats IX
Corynebacterium pseudotuberculosis infeksjon hos geit IX. Effekten av vaksinasjon mol naturlig infeksjon
The Effect of Vaccination against Natural Infection
Acta Veterinaria Scandinavica volume 30, pages 285–293 (1989)
A vaccination trial was carried out in 10 infected herds. The trial included 247 female kids, the number of animals in each herd varying from 15 to 38. About half of the animals in each herd were vaccinated twice at 3 to 4 week intervals, the first vaccination being carried out before the age of 4 months. A combination of a crude filtrate of C. pseudotuberculosis toxoid with whole organisms, was used.
Overall, the prevalence of animals with superficial swellings was higher in the un vaccinated than in the vaccinated group during the first 1–2 years following immunization. However, in some herds superficial swellings were as common in vaccinated as in unvaccinated animals.
An antibody response following vaccination was demonstrated in the hemolysis inhibition test, but not in the bacterial agglutination test. Superficial swellings were more common in vaccinated animals which were negative than in animals which were positive in the hemolysis inhibition test at 11/2 months after vaccination.
The vaccine used in the present study, was not sufficiently efficacious to be recommended as the only protective measure against caseous lymphadenitis in Norwegian goat herds.
Ett vaksinasjonsforsøk ble utført i 10 infiserte besetninger. Det var ialt 247 dyr med i forsøket, og det var fra 15 til 38 dyr i hver besetning. Omlag halvparten av dyrene i hver besetning ble vaksinert 2 ganger med 3–4 ukers mellomrom. Første vaksinasjon ble utført før dyrene var 4 måneder gamle. Dyrene ble vaksinert med filtrert urenset toksoid og hele drepte bakterier av C. pseudo-tuberculosis.
Prevalensen av dyr med overfladiske hevelser var høyere i den uvaksinerte enn i den vaksinerte gruppa ved undersøkelser foretatt i løpet av de første 1–2 årene etter immunisering. Overfladiske hevelser var imidlertid like vanlig hos vaksinerte som hos uvaksinerte dyr i noen besetninger.
Etter vaksinering ble det påvist antistoffrespons ved a nti hemolysin test, men ikke ved bakterieag-glutinasjonstest. Overfladiske hevelser forekom vanligere hos dyr som var negative enn hos dyr som var positive ved antihemolysintest 1 1/2 måned etter vaksinering.
Den vaksinen som ble benyttet i foreliggende undersøkelse gav for dårlig beskyttelse til å kunne anbefales som eneste beskyttelsestiltak mot kaseos lymfadenitt i norske geitebesetninger.
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The investigation was supported by grants from the Agricultural Research Council of Norway.
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Holstad, G. Corynebacterium Pseudotuberculosis Infection in Goats IX. Acta Vet Scand 30, 285–293 (1989). https://doi.org/10.1186/BF03548033
- whole killed bacteria
- crude filtrated toxoid
- infected goat herds