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The Effect of Detomidine Hydrochloride on the Electrical Activity of Uterus in Pregnant Mares
Effekten av detomidin hydroklorid på den elektriska aktiviteten i livmodern hos dräktiga ston
Acta Veterinaria Scandinavica volume 30, pages 307–311 (1989)
Abstract
The effect of detomidine on the electrical activity of the uterus was studied during the last trimester of pregnancy in 6 mares.
The effect was observed in 3–5 min after the i.m. injection and it lasted for 50–70 min. 20 and 40 μg/kg b.w. doses of detomidine decreased the myometrial electrical activity, whereas 60 μg/kg dose did not have any effect on the activity.
The results suggested that 20, 40 and 60 μg/kg b.w. doses of detomidine can be administered to mares during the last trimester of pregnancy without the risk of abortion induced by increased uterine electrical activity.
Sammendrag
Effekten av detomidin på den elektriska aktiviteten i livmodern undersöktes under den sista trimestern hos 6 dräktiga ston.
Effekten observerades 3–5 min efter i.m, injektion, och den kvarstod i 50–70 min. Doser av 20 och 40 μg/kg kroppsvikt minskade den elektriska aktiviteten i myometriet, medan en dos av 60 μg/kg inte hade någon effekt på aktiviteten.
På basen av dessa resultat kan man utgå ifrån att doser av 20, 40 och 60 μg/kg detomidin /kg kroppsvikt kan ges åt ston under den sista dräktig-hetstrimestem utan risk för abort inducerad av en ökad elektrisk aktivitet i livmodern.
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Jedruch, J., Gajewski, Z. & Kuussaari, J. The Effect of Detomidine Hydrochloride on the Electrical Activity of Uterus in Pregnant Mares. Acta Vet Scand 30, 307–311 (1989). https://doi.org/10.1186/BF03548036
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DOI: https://doi.org/10.1186/BF03548036