Skip to main content
  • Published:

The Influence of Regular Physical Activity on the Cell-Mediated Immunity in Pigs

Abstract

The influence of moderate regular physical activity on the cell-mediated immunity was studied in growing pigs. Ten animals were subjected to physical training on a large animal treadmill, and 10 were kept in their pens throughout a 12-week experimental period.

Regardless of whether the pigs underwent training or not, a whole blood lymphocyte stimulation test performed at 3 stages of the experiment revealed an equal ability of the cells to respond to stimulation induced by pokeweed mitogen and phytohaemaglutinin.

The influence of serum from the pigs of the trained and untrained groups was studied in a stimulation test with purified mononuclear cells obtained from 2 healthy control pigs. The results indicated that no additional serum factors released by the physical training altered the blastogenic response of these lymphocytes.

It is concluded that moderate exercise should not be regarded as a stressor which alters the cellular immunity in pigs.

References

  • Andersson K: SLU-feeding scale for growing fattening pigs. The Research Conference. Report from the Research Information Centre at the Swedish University of Agricultural Sciences. 1985, 67:2.

    Google Scholar 

  • Blecha F, Minocha HC: Suppressed lymphocyte blastogénie responses and enhanced in vitro growth of infectious bovine rhinotracheitis virus in stressed feeder calves. Amer. J. vet. Res. 1983, 44, 2145–2148.

    CAS  PubMed  Google Scholar 

  • Davis CTM, Few JD: Effects of exercise on adrenocortical function. J. appl. Physiology. 1973, 35, 887–891.

    Article  Google Scholar 

  • Edfors-Lilja I, Lundström K, Nyberg L, Rund- gren M: Influence of the hal locus and standardized stress on antibody response and in vitro reactivity of peripheral blood lymphocytes in pigs. Vet. Immunol. Immunpathol. 1987, 14, 157–171.

    Article  CAS  Google Scholar 

  • Eskola J, Runskanen O, Soppi E, Viljanen MK, Järvinen M, Toivonen H, Kuovalainen K: Effect of sport stress on lymphocyte transformation and antibody formation. Clin. exp. Immunol. 1978, 32, 339–345.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Essén B, Lindholm A, Thornton J: Histochemical properties of muscle fibre types and enzyme activities in skeletal muscles of standardbred trotters of different ages. Equine Vet. J. 1980, 12, 175–180.

    Article  Google Scholar 

  • Essén-Gustavsson B, Karlström K, Lindholm A: Fibre types, enzyme activities and substrate utilisation in skeletal muscles of horses competing in endurance rides. Equine Vet. J. 1984, 16, 197–202.

    Article  Google Scholar 

  • Essén-Gustavsson B: Activity and inactivity - related muscle adaption in the animal kingdom. In Biochemistry of exercise VI. Ed. Bengt saltin. Human Kinetics. Publishers Champaign Illinois. 1986, 436–444.

    Google Scholar 

  • Fossum C, Larsson B, Matsson P: Development of mononuclear cell subpopulations and their function during calf hood. J. Vet. Med. 1986 B, 55, 518–527.

    Article  Google Scholar 

  • Galbo H: Hormonal and metabolic adaption to exercise. Georg Thieme Verlag, Stuttgart, New York 1983.

  • Gallo-Torres HE: Absorption. In: L. J. Machlin (Ed.): Vitamin E - A Comprehensive Treatise. Vol. 1. Marcel Dekker Inc., New York 1980.

  • Heijnen CJ, Bevers C, Kavelaars A, Ballieux RE: Effect of alpha-endorphin on the antigen - induced primary antibody response of human blood B cells in vitro. J. Immunol. 1986, 136, 213–216.

    CAS  PubMed  Google Scholar 

  • Heijnen CJ, Croiset G, Zijlstra J, Ballieux RE: Modulation of lymphocyte function by endorphins. Ann. N.Y. Acad. Sei. 1987, 496, 161–165.

    Article  CAS  Google Scholar 

  • Jensen M, Fossum C, Ederoth M, Hakkarainen J: The effect of vitamin E on the cell-mediated immunity in pigs. J. Vet. Med. B. 1988, 35, 549–555.

    Article  CAS  Google Scholar 

  • Johnson HM, Smith EM, Torres BA, Blalock JE: Regulation of the in vitro antibody response by neuroendocrine hormones. Proc. Natl. Acad. Sei. (USA) 1982, 72, 4171–4174.

    Article  Google Scholar 

  • Kelley KW: Stress and immune function: A bibliographic review. Ann. Rech. Vét. 1980, 11, 445–478.

    CAS  PubMed  Google Scholar 

  • Kelley KW, Mertsching HJ, Mathison BA, Kissinger CR: Physiologic concentrations of cortisol suppress mitogenesis of porcine lymphoid cells. J. Anim. Sei. 1982, 55, 1, 191.

    Google Scholar 

  • Kurcz EV, Lawrence LM, Kelley KW, Miller PA: The effect of intense exercise on the cell-mediated immune response of horses. Subm. for publication 1987.

    Google Scholar 

  • Monjan AA: Stress and immunologic competence: Studies in animals. In” Psychoneuroimmuno- logy” Ed. R. Ader. Academic Press, New York 1981, 185–228.

    Google Scholar 

  • Reiland S: Osteochondrosis in the pig. A morphologic and experimental investigation with special reference to the leg weakness syndrome. Thesis 1975.

    Google Scholar 

  • Rülcker C: The influence of physical training and short-time physical stress on colour, fluid loss, pH, adenosine triphosphate and glycogen of the gracilis muscle in pigs. Acta vet. scand. Suppl. 24, 1968.

    Google Scholar 

Download references

Acknowledgements

This work was supported by grants from the Swedish Council for Forestry and Agricultural Research.

The author wishes to thank Docent Caroline Fossum for scientific advice and critical views on the manuscript and Professor Sune Persson and Docent Birgitta Essén-Gustavsson for critical reading of the manuscript.

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jensen, M. The Influence of Regular Physical Activity on the Cell-Mediated Immunity in Pigs. Acta Vet Scand 30, 19–26 (1989). https://doi.org/10.1186/BF03548064

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548064

Keywords