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Hyaluronan Turnover in the Synovial Fluid in Metacarpophalangeal–and Middle Carpal Joints in Standardbred Horses

Acta Veterinaria Scandinavica volume 37, pages 147–151 (1996)Cite this article

Abstract

The biological turnover of hyaluronan (sodium hyaluronate) of different molecular weights (0.6×106 and 2.5×106 Daltons) was studied in the synovial fluid of the middle carpal and metacarpophalangeal joints of 6 clinically healthy Standardbred horses. The hyaluronan was radioactively labelled with 14C. The biological half-life (t1/2) was calculated from repeated synovial samples after injection of the labelled hyaluronan. The mean t1/2 in the metacarpophalangeal joints was 9.7 h for low molecular weight hyaluronan and 8.9 h for high molecular weight hya-luronan and in the middle carpal joints 16.0 h and 12.5 h respectively. There was no sig-nificant difference in turnover of the different molecular weights of hyaluronan.

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Authors and Affiliations

  1. Department of Medicine & Surgery, Swedish University of Agricultural Sciences, P.O. Box 7018, S-75007, Uppsala, Sweden

    A. Lindholm & B. Ronéus

  2. Pherrovet AB, Box 835, 201 80, Malmö, Sweden

    G. Lindblad

  3. Department of Clinical Chemistry, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden

    B. Jones

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  1. A. Lindholm
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  2. B. Ronéus
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  3. G. Lindblad
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  4. B. Jones
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Correspondence to A. Lindholm.

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Lindholm, A., Ronéus, B., Lindblad, G. et al. Hyaluronan Turnover in the Synovial Fluid in Metacarpophalangeal–and Middle Carpal Joints in Standardbred Horses. Acta Vet Scand 37, 147–151 (1996). https://doi.org/10.1186/BF03548107

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Acta Veterinaria Scandinavica

ISSN: 1751-0147