Skip to main content
Download PDF
  • Published:

Distribution of Penicillin G in Serum and Tissue Cage Fluid in Cattle*

Distribution av penicillin i serum och vävnadskammarvätska hos kalv

Acta Veterinaria Scandinavica volume 27, pages 313–325 (1986)Cite this article

Abstract

The penetration of penicillin into tissue cage fluid (TCF) in calves was studied after intravenous and intramuscular injection. The penicillin concentrations in TCF were lower than in serum and maximum was reached much later. Intravenous injection of benzyl-penicillin gave significantly higher levels in TCF than intramuscular injection. The penetration after procaine penicillin was very slow. The results showed that the serum peak rather than the area under curve determines the penetration of penicillin. Repeated intramuscular injections of benzylpenicillin and procaine penicillin caused an accumulation of penicillin in TCF. Similar levels were however reached by one single intravenous injection. The clinical counterparts to the used tissue cage model are abscesses. It was concluded that if high penicillin concentration are desireable in such foci, the drug must be given in a way that gives as high serum peaks as possible.

Sammanfattning

Koncentrationerna av penicillin i serum och vävnadsvätska uppsamlad med hjälp av vävnadskammare studerades hos kalv. Intravenös injektion gav mycket högre koncentrationer i vävnadskammare än intramuskulär. Penetrationen till kammarvätskan skedde mycket långsamt efter injektion av prokainpenicillin. Resultaten visade att höga koncentrationstoppar i serum har en avgörande betydelse för penetrationen till kammarvätskan. Upprepade intramuskulära injektioner gav en ackumulation av penicillin i kamrarna. Lika höga koncentrationer kunde dock uppnås efter en enida intravenös injektion. Den kilniska motsvarigheten til vävnadskammare är abscesser. Det konkluderades att när höga penicillinkoncentrationer är önskvärda i svårtillgängliga infektionsfoci bör penicillin tillföras på ett sådant sätt att högsta möjliga serumkoncentrationer uppnås.

References

  • Adam, D., B. Reichart, J. Beyer, B. Kemke, B. Rothenfusser, C. Weinhold & M. Helmerking: Diffusion of cefradine and cefalothin into interstitial fluid of human volunteers with tissue cages. Infection 1978, 6, Suppl. 1, 78–81.

    Article  CAS  Google Scholar 

  • Baggot, J.D.: Principles of Drug Disposition in Domestic Animals. W. B. Saunders Co. Philadelphia/London/Toronto 1977.

    Google Scholar 

  • Barza, M. & Weinstein: Penetration of antibiotics into fibrin loci in vivo. 1. Comparison of penetration into fibrin clots, abscesses and interstitial fluid. J. infect. Dis. 1974, 129, 59–65.

    Article  CAS  Google Scholar 

  • Barza, M.: Principles of tissue penetration of antibiotics. J. antimicrob. Chemother. 1981, 8, Suppl. C, 7–28.

    Article  CAS  Google Scholar 

  • Bengtsson, B., J. Luthman & S.O. Jacobsson: Evaluation of a tissue cage model for use in cattle. Acta vet. scand. 1984, 25, 480–494.

    Article  CAS  Google Scholar 

  • Bergan, T.: Kinetics of tissue penetration. Scand. J. infect. Dis. 1978, Suppl. 1, 36–46.

    Google Scholar 

  • Carbon, C., A. Contrepois, N. Brion & S. Lamotte-Barrillon: Penetration of cefazolin, cephaloridin and cef am ondoie into interstitial fluid in rabbits. Antimicrob. Agents. Chemother. 1977, 11, 594–598.

    Article  CAS  Google Scholar 

  • Cars, O., C. Henning & S.E. Holm: Penetration of ampicillin and dicloxacillin into tissue cage fluid in rabbits: Relation to serum and tissue protein binding. Scand. J. infect. Dis. 1984, 13, 69–74.

    Article  Google Scholar 

  • Chisholm, G.D., P.M. Waterworth, J.S. Calnan & L.P. Garrod: Concentration of antibacterial agents in interstitial tissue fluid. Brit med. J. 1973, 1, 569–573.

    Article  CAS  Google Scholar 

  • Chisholm, G.D., C.B. Smith, P.M. Waterworth & J.S. Calnan: Factors influencing the distribution of antibacterial agents in interstitial tissue fluid: molecular size and protein binding. Infection, 4, suppl. 2, 123–127.

  • Holm, S.E., C. Ekedahl & A.M. Bergholm: Comparison of antibiotic assays using different experimental models and their possible clinical significance. Scand. J. infect. Dis. 1978, suppl. 14, 214–220.

    Google Scholar 

  • Luthman, J., B. Bengtsson & S.O. Jacobsson: Penetration of antimicrobial agents into tissue cage fluid in cattle. Zbl. Vet. Med. A, 1984, 31, 303–313.

    Article  CAS  Google Scholar 

  • Marshal, A.B. & G.B. Palmer: Injection sites and drug bioavailability. In: Trends in Veterinary Pharmacology and Toxicology. Ed. van Miert, A. S. J. P. A. M., J. Frens & van der Kreek. Elsevier Scientific Publishing Gomp. Amsterdam/Oxford/New York 1980.

  • Ryan, D.M.: Implanted tissue cages: A critical evaluation of their relevance in measuring tissue concentrations of antibiotics. Scand. J. infect. Dis. 1978, suppl. 13, 58–62.

    Google Scholar 

  • Rylander, M., S.E. Holm, R. Norrby & J.E. Brorson: Studies on the pharmacokinetics of cefoxitin, cefuroxime, cephaloridine and cephalothin using subcutaneous tissue cages. Scand. J. infect. Dis. 1978, 13, 52–57.

    CAS  Google Scholar 

  • Schreiner, A., K.B. Helium, A. Diyranes & I. Bergman: Transfer of penicillin G and ampicillin into human skin blisters induced by suction. Scand. J. infect. Dis. 1978, suppl. 14, 233–237.

    Google Scholar 

  • Sullins, K., N.T. Messer & L. Nelson: Serum concentrations of penicillin in the horse after repeated intramuscular injections of procaine penicillin G alone or in combination with benzathine penicillin and/or phenylbutazone. Amer. J. vet. Res. 1984, 45, 1003–1007.

    CAS  PubMed  Google Scholar 

  • Stanton, A., R.J. Byivater & G.H. Palmer: The use of tissue cages in calves to study distribution of antibiotics in interstitial fluid. Proc. 2nd Conf. European Assoc. Vet. Pharmacol. Toxicol. Toulouse 1980.

    Google Scholar 

  • Taylor, A. & H. Gibson: Concentrating ability of lymphatic vessels. Lymphology 1975, 8, 43–49.

    CAS  PubMed  Google Scholar 

  • Tight, R.R. & A.C. White: Serum and subcutaneous chamber dynamics of penicillins after single large parenteral doses. Anti- microb. Agents Ghemother. 1980, 17, 229–234.

    Article  CAS  Google Scholar 

  • van Etta, L., C.E. Fasching, L.R. Peterson & D.N. Gerding: Comparison study of the kinetics of ceftizoxime penetration into extravascular spaces with known surface area/volume ratio in vitro and in vivo in rabbits. Antimicrob. Agents Chemother. 1983, 23, 49–53.

    Article  CAS  Google Scholar 

  • Waterman, N.G. & L.B. Kastan: Interstitial fluid and serum antibiotic concentrations. Arch. Surg. 1972, 105, 192–196.

    Article  CAS  Google Scholar 

  • Ziv, G., M. Wanner & J. Nicolet: Distribution of penicillin G, dihydro- streptomycin, oxytetracycline, and chloramphenicol in serum and subcutaneous chamber fluid. J. vet. Pharmacol. Therap. 1982, 5, 59–69.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Cattle and Sheep Diseases, College of Veterinary Medicine, Swedish University of Agricultural Sciences, S-750 07, Uppsala, Sweden

    Jan Luthman & S. O. Jacobsson

Authors
  1. Jan Luthman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. O. Jacobsson
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Luthman, J., Jacobsson, S.O. Distribution of Penicillin G in Serum and Tissue Cage Fluid in Cattle*. Acta Vet Scand 27, 313–325 (1986). https://doi.org/10.1186/BF03548146

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548146

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147