Naturally Occurring Canine Nephrotic Syndrome is a Potentially Hypercoagulable State

Abstract

Fourteen dogs with naturally occurring nephrotic syndrome were evaluated for abnormalities in the hemostatic system. Histopathologic diagnoses included 8 dogs with membraneous glomerulonephritis, 1 dog with acute glomerulon-ephritis, 2 dogs with idiopathic glomerulopathy, and 2 dogs with amyloidosis. The coagulation protein assays performed included concentrations of factors V, VII, VIII: C, IX, X, fibrinogen (I), anti-thrombin III, and plasminogen. Thrombocyte counts were also performed. All of these analytes were significantly elevated (P < 0.05) with the exception of ATIΠ which was significantly decreased (P < 0.05). Five of the dogs had histologic evidence and 1 dog had angiographic evidence of thrombosis and thromboembolism. Naturally occurring canine nephrotic syndrome thus represents a potentially hypercoagulable state and may serve as a valuable model in the study of certain components of the human disease.

Sammendrag

Fjorten hunde med naturligt forekommende nefrotisk syndrom blev undersøgt for abnormaliteter i hæmostasesystemet. Histopatologisk diagnosticeredes membranøs glomerulonefritis hos 8, idiopatisk glomerulopati hos 2, akut glomerulonefritis hos. 1, subakut glomerulonefritis hos 1 og amyloidose hos 2 hunde. Koncentrationen af følgende koagulationsproteiner blev bestemt: faktorerne V, VII, VIII:C, IX, X, fibrinogen (1), antithrombin III og plasminogen. Trombocyttælling blev også foretaget. Alleparametre var signifikant forhøjede (P < 0,05) med undtagelse af ATIII, som var signifikant formindsket (P < 0,05). Hos 5 hunde fandtes histologiske og hos 1 hund angiografiske tegn på tromboembolisme. Naturligt forekommende nefrotisk syndrom hos hund repræsenterer således en potentiel hyperkoagulationstilstand og kan tjene som værdifuld model for studiet af visse elementer af den humane lidelse.