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Morphologic Evaluation of Acute Endometritis in Mares with Differing Resistance to Uterine Infections
Morfologisk bedömning av akut endometrit hos ston med varierande motståndskraft mot infektioner i livmodern
Acta Veterinaria Scandinavica volume 27, pages 378–387 (1986)
Abstract
The study was designed to determine differences between normal mares and mares with endometrial pathology in the inflammatory response after bacterial challenge. Six normal mares (biopsy category I) and 4 mares with pathological endometrial changes (biopsy category II) were given an intrauterine infusion of β-hemolytic streptococci on the second day of estrus. All mares had a similar kind of inflammatory response after the bacterial inoculation as assessed by rectal and vaginal examinations. There were no significant differences in the amount of discharge, uterine tone, uterine size and cervical relaxation between the groups. Leukocytic response, as determined by endometrial smears and biopsies, was of the same magnitude in both groups. Two mares from the pathological group were not able to eliminate the infection, but had vaginal discharge and bacteriologically positive uterine swabs until the end of the experiment. It is concluded that the inability of some mares to clear uterine infections cannot be explained by a deficient inflammatory response.
Sammendrag
Föreliggande undersökning utfördes för att klargöra skillnaden mellan normala ston och ston med patologiska förändringar i endometriet beroende på en inflammatorisk reaktion ansluten till bakteriell infektion. Sex normala ston (biopsi kategori I) och 4 ston med patologiska förändringar i endometriet (biopsi kategori II) inokulerades intrauterint med β-hämoly tiska streptokocker under den andra brunstdagen. Alla ston uppvisaide en likadan inflammatorisk reaktion efter den bakteriella inokulationen, vilket konfirmerades vid rektala och va/ginala undersökningar. Inga signifikanta skillnader påvisades mellan de två grupperna visavis mängden av flytning, livmoderns tonus och storlek, samt avslapningen av cervix. Leukocytreaktionen, som bestämdes med hjälp av endometriella utstryk och biopsier, var av samma storleksgrad i båda grupperna. Två ston i den patologiska gruppen förmådde inte eliminera infektionen, utan hade vaginal flytning och bakteriologiskt positiva prov från livmodern ända till undersökningens slut. Vår slutsats är, att oförmåga att klara uterina infektioner inte kan förklaras bero på en bristande inflammatorisk reaktion.
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Katila, T., Lock, T.F., Ely, R.W. et al. Morphologic Evaluation of Acute Endometritis in Mares with Differing Resistance to Uterine Infections. Acta Vet Scand 27, 378–387 (1986). https://doi.org/10.1186/BF03548152
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DOI: https://doi.org/10.1186/BF03548152