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Bovine Leukocyte Adhesion Deficiency in Danish Holstein-Friesian Cattle

II. Patho-Anatomical Description of Affected Calves

Abstract

The patho-anatomical findings in 3 Danish Holstein-Friesian calves affected with bovine leukocyte adhesion deficiency (BLAD) are described. The diagnosis was confirmed by genotyping for the BLAD mutagene by polymerase chain reaction technique. The main clinical symptoms were general unthriftyness and leukocytosis with a high proportion of neutrophils. None of the calves suffered from severe infections and the major pathological changes were different from those described in previously published cases. One calf had a fibro-granulom-atous perilienitis and calcification of splenic stroma and pulmonic arteries. In the other cases only minor pathological changes were present.

References

  • Hagemoser WA, Roth JA, Löfstedt J, Fagerland JA: Granulocytopathy in a Holstein heifer. J. Amer, vet. med. Assoc. 1983,183, 1093–1094.

    CAS  Google Scholar 

  • Jain NC: Schalm’s Veterinary Hematology. Lea & Febiger. Philadelphia. 1986.4th. edition. 1221 pp.

    Google Scholar 

  • Jubb KVF, Kennedy PC, Palmer N: Pathology of Domestic Animals vol. 3. Academic Press, Inc., San Diego. 1985. 3th. edition. 527 pp.

    Google Scholar 

  • Jørgensen CB, Agerholm JS, Pedersen J, Thomsen PD: Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle -1. PCR screening and allele frequency estimation. Acta vet. scand. 1993,34,231–236.

    Article  Google Scholar 

  • Kaneko J J: Clinical biochemistry of domestic animals. Academic Press, Inc. San Diego. 1989. 4th edition. 932 pp.

    Google Scholar 

  • Kehrli ME, Jr., Schmalstieg FC, Anderson DC, Maaten MJ Van Der, Hughes BJ, Ackermann MR, Wilhelmsen CL, Brown GB, Stevens MG, Whetstone CA: Molecular definition of the bovine granulocytopathy syndrome: Identification of deficiency of the Mac-1 (CDllb/CD18) glycoprotein. Amer. J. vet. Res. 1990,51, 1826–1836.

    PubMed  CAS  Google Scholar 

  • Kehrli ME, Jr., Shuster DE, Ackermann MR: Leukocyte adhesion deficiency among Holstein cattle. Cornell Vet. 1992,82,103–109.

    PubMed  Google Scholar 

  • Nagahata H, Nöda H, Takahashi K, Kurosawa T, So-noda M: Bovine granulocytopathy syndrome: Neutrophil dysfunction in Holstein Friesian calves. J. vet. Med. A 1987,34, 445–451.

    Article  CAS  Google Scholar 

  • Nielsen JS, Jørgensen CB, Thomsen PD: Bovine leukocyte adhesion deficiency syndrome - En ny arvelig defekt hos Sortbroget Dansk Malkerace (Bovine leukocyte adhesion deficiency syndrome - A new hereditary disease in the Danish Holstein-Friesian breed). Dansk VetTidsskr. 1992, 75, 276–277.

    Google Scholar 

  • Shuster DE, Kehrli ME, Jr., Ackermann MR, Gilbert RO: Identification and prevalence of a genetic defect that causes leukocyte adhesion deficiency in Holstein cattle. Proc. Natl. Acad. Sci. 1992,89, 9225–9229.

    Article  CAS  Google Scholar 

  • Stöber M, Kuczka A, Pohlenz J: Bovine Leukozy-ten-Adhäsions-Defizienz (BLAD = Hagemoser-Takahashi-Syndrom): Klinische, pathologischanatomische und -histologische Befunde (Bovine Leukocyte Adhesion-Deficiency (BLAD = Hagemoser-Takahashi-Syndrome): Clinical, patho-anatomical and -histological findings). Dtsch. tierärztl. Wschr. 1991, 98, 443–448.

    Google Scholar 

  • Takahashi K, Miyagawa K, Abe S, Kurosawa T, So-noda M, Nakade T, Nagahata H, Nöda H, Chi-haya Y, Isogai E: Bovine granulocytopathy syndrome of Holstein-Friesian calves and heifers. Jpn. J. vet. Sci. 1987, 49, 733–736.

    Article  CAS  Google Scholar 

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Agerholm, J.S., Houe, H., Jørgensen, C.B. et al. Bovine Leukocyte Adhesion Deficiency in Danish Holstein-Friesian Cattle. Acta Vet Scand 34, 237–243 (1993). https://doi.org/10.1186/BF03548187

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