Skip to main content
Download PDF
  • Published:

Investigations on the Occurrence of Hereditary Diseases in the Danish Cattle Population 1989-1991

Acta Veterinaria Scandinavica volume 34, pages 245–253 (1993)Cite this article

Abstract

The methods of the Danish Bovine Genetic Disease Programme are outlined, and the results obtained during the first 3 years in function are described. The most common disease reported was spinal muscular atrophy in calves of the Red Danish Dairy breed with 312 reports. Necropsy was performed on 162 cases, and spinal muscular atrophy was diagnosed in 82 of these. Bovine progressive degenerative mye-loencephalopathy, rectovaginal constriction, syndrome of arthrogryposis and palatoschisis, hereditary chondrodysplasia (2 different types), syndactylism, epitheliogenesis imperfecta, and osteogenesis imperfecta was diagnosed with 1 case each. Lethal trait A46 was diagnosed in 4 calves. Some of these diseases have not previously been described in Denmark, and epitheliogenesis imperfecta was for the first time diagnosed in the Hereford breed. Chromosome translocation 1/29 was detected in the Blonde d’Aquitaine (BAQ), Limousine, and Red Danish Dairy breed. The aberration occurred frequently in BAQ. Furthermore, a complex chromosome translocation t(l;8;9)(q45;ql3;q26) was detected in the Red Danish Dairy breed.

References

  • Agerholm JS: Undersøgelser over forekomsten af arvelige sygdomme og udviklingsanomalier i den danske kvaegpopulation. (Investigations on the occurrence of hereditary diseases and congenital malformations in the Danish cattle population). PhD Thesis, The Royal Veterinary and Agricultural University and The National Veterinary Laboratory, Copenhagen, 1992.

    Google Scholar 

  • Agerholm JS, Basse A: Spinal muscular atrophy in calves of the Red Danish Dairy breed. Vet. Rec. (submitted).

  • Agerholm JS, Houe H, Jørgensen CB, Basse A: Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. II. Patho-anatomical description of affected calves. Acta vet. scand. 1993, 34, 237–243.

    Article  CAS  Google Scholar 

  • Andresen E, Christensen K, Jensen PT, Venge O, Rasmussen PG, Basse A, Neimann-Sørensen A, Jensen B, Nielsen J: Dvaergvaekst hos kvaeg af Rød Dansk Malkerace (Achondroplasia bovis typus RDM). (Dwarfism in Red Danish cattle (Bovine achondroplasia: type RDM). Nord. Vet.-Med. 1974,26, 681–691.

    PubMed  CAS  Google Scholar 

  • Christensen K, Agerholm JS, Larsen B: Dairy breed bull with complex chromosome translocation: Fertility and linkage studies. Hereditas 1992, 117, 199–202.

    Article  CAS  Google Scholar 

  • Crew, FAE: The significance of an achondroplasia-like condition met with in cattle. Proc. Royal Society of London, Series B 1924, 95, 228–255.

    Google Scholar 

  • Cribiu EP, Popescu CP: Distribution of the 1/29 Ro-bertsonian translocation in France. Proc. IV Eur. Coloq. Cytogenet. Dornest. Anim. 1980,130–135.

    Google Scholar 

  • Denholm LJ, Cole WG: Heritable bone fragility, joint laxity and dysplastic dentin in Friesian calves: a bovine syndrome of osteogenesis imperfecta. Austr. vet. J. 1983,60, 9–17.

    Article  CAS  Google Scholar 

  • Dyrendahl S: Epitheliogenesis imperfecta inom SRB-rasen (Epitheliogenesis imperfecta in Swedish Red and White cattle). Nord. Vet.-Med. 1956,8, 953–958.

    Google Scholar 

  • Freshney, RI: Culture of Animal Cells. A manual of basic technique. Alan R. Liss, INC. New York. 1983,1st. ed., pp. 295.

    Google Scholar 

  • Gustavsson I: Cytogenetics, distribution and pheno-typic effects of a translocation in Swedish cattle. Hereditas 1969, 63, 68–169.

    Article  CAS  Google Scholar 

  • Hansen KM: Weaver-syndromet hos amerikansk Brunkvaeg (weaver syndrome in Brown Swiss cattle). Dansk VetTidskr. 1984, 67, 425–429.

    Google Scholar 

  • Hansen KM, Elleby F: Anlaegsbaerende tyre for RVC-syndromet hos dansk Jersey-kvaeg -Bekaempelsesarbejdets hidtidige forl0b i Danmark. (RVC carrier bulls in Danish Jersey cattle - The fight against the RVC syndrome in Denmark). Dansk VetTidskr. 1985, 68, 941–947.

    Google Scholar 

  • Jayasekara MU, Leipold HW: Epitheliogenesis imperfecta in Shorthorn and Angus cattle. Zbl. Vet. Med. A 1979,26,497–501.

    Article  CAS  Google Scholar 

  • Jensen PT, Rasmussen PG, Basse A: Congenital osteogenesis imperfecta in Charolais cattle. Nord. Vet.-Med. 1976,28, 304–308.

    PubMed  CAS  Google Scholar 

  • Jubb KVF, Kennedy PC, Palmer N: Pathology of Domestic Animals vol. 1. Academic Press, Inc. San Diego. 1993, 4th. ed., p. 42–43.

    Google Scholar 

  • Jørgensen CB, Agerholm JS, Pedersen J, Thomsen PD: Bovine leukocyte adhesion deficiency in Danish Holstein-Friesian cattle. I. PCR screening and allele frequency estimation. Acta vet. scand. 1993,34, 231–236.

    Article  Google Scholar 

  • Kovács A, Villagomez DAF, Gustavsson I, Lindblad K, Foote RH, Howard TH: Synaptoneal complex analysis of a three breakpoint translocation in a bull. Cytogenet. Cell Genet. 1992,61, 195–201.

    Article  Google Scholar 

  • Leipold HW, Mills JHL, Huston K: Epitheliogenesis imperfecta in Holstein-Friesian calves. Can. vet. J. 1973, 14, 114–118.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Leipold HW, Cates WF, Radostits OM, Howell WE: Arthrogryposis and associated defects in newborn calves. Amer. J. vet. Res. 1970, 31, 1367–1374.

    PubMed  CAS  Google Scholar 

  • Leipold HW, Cates WF, Radostits OM, Howell WE: Spinal dysraphism, arthrogryposis and cleft palate in newborn Charolais calves. Can. vet. J. 1969,10, 268–273.

    PubMed  PubMed Central  CAS  Google Scholar 

  • Nielsen JS: Hereditary diseases in cattle - especially of current concern in European AI-work. Proc. 3th. Meeting of A.I.-Vets in the EEC 1991,20–30.

    Google Scholar 

  • Nielsen JS, Christensen K: Kromosomtranslokation 1/29 hos kvaeg. (Chromosome translocation 1/29 in cattle). Dansk VetTidskr. 1989, 72, 586–590.

    Google Scholar 

  • Nielsen JS, Christensen K: Kromosomtranslokation 1/29 hos dansk Limousine kvaeg. (Chromosome translocation 1/29 in Danish Limousine cattle). Dansk VetTidskr. 1990, 73, 1036–1039.

    Google Scholar 

  • Nielsen JS, Jensen KM: Bovin syndactyli hos SDM (Bovine syndactylism in a Danish Holstein-Friesian calf). Dansk VetTidskr. 1990, 73, 699–701.

    Google Scholar 

  • Nygaard H (ed): Årsberetning 1992, Landsudvalget for Kvaeg (Year book 1992, National Committee on Danish Cattle Husbandry), p. 34–35.

  • Rasbech NO: Arvelige misdannelser; Med henblik på registrering af letale og semiletale anlaeg hos kvaeg (Hereditary malformations with special regard to registration of lethal and semilethal conditions in cattle). Nord. Vet.-Med. 1960 (suppl. I), 12, 1–57.

    Google Scholar 

  • Stuart LD, Leipold, HW: Bovine progressive degenerative myeloencephalopathy (“weaver”) of Brown Swiss cattle II: clinical and laboratory findings. Bovine Pract. 1983,18, 133–146.

    Google Scholar 

  • Stuart LD, Leipold, HW: Lesions in bovine progressive degenerative myeloencephalopathy (“weaver”) of Brown Swiss cattle. Vet. Pathol. 1985, 22, 13–23.

    Article  CAS  Google Scholar 

  • Stöber, M: Parakeratose beim schwarzbunten Niederungskalb. 1. Klinisches Bild und Ätiologi (Parakeratosis in black pied calves. 1. Clinical findings and etiology). Dtsch. tierärztl. Wschr. 1971, 78, 257–265.

    Google Scholar 

  • Termine JD, Robey PG, Fisher LW, Shimokawa H, Drum MA, Conn KM, Hawkins GR, Cruz JB, Thompson KG: Osteonectin, bone proteoglycan, and phosphophoryn defects in a form of bovine osteogenesis imperfecta. Proc. Natl. Acad. Sci. USA 1984, 81,2213–2217.

    Article  CAS  Google Scholar 

  • Thomsen PD, Nielsen JS: PCR-screening for carriers of hereditary citrullinaemia in Danish Holstein-Friesian bulls. Acta vet. scand. 1991,32, 279–282.

    Article  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to the Danish breeding associations, the National Committee on Danish Cattle Husbandry, the Danish Veterinary Service, and to the Department of Radiology and the Division of Large Animal Medicine, the Royal Veterinary and Agricultural University for cooperation. The investigations were supported by a grant from the Danish Research Academy, the National Committee on Danish Cattle Husbandry, and the National Veterinary Laboratory.

Author information

Authors and Affiliations

  1. Department of Pathology and Epidemiology, National Veterinary Laboratory, Copenhagen, Department of Pharmacology and Pathobiology, Laboratory of Veterinary Pathology, and Department of Animal Science and Animal Health, Division of Animal Genetics, Royal Veterinary and Agricultural University, Bülowsvej 27, DK-1790, Copenhagen, Denmark

    J. S. Agerholm, A. Basse & K. Christensen

Authors
  1. J. S. Agerholm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Basse
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Christensen
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Agerholm, J.S., Basse, A. & Christensen, K. Investigations on the Occurrence of Hereditary Diseases in the Danish Cattle Population 1989-1991. Acta Vet Scand 34, 245–253 (1993). https://doi.org/10.1186/BF03548188

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548188

Keywords

Acta Veterinaria Scandinavica

ISSN: 1751-0147