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Immune Response to other Agents of Calves Persistently Infected with Bovine Virus Diarrhoea Virus (BVDV)

Acta Veterinaria Scandinavica volume 34, pages 305–310 (1993)Cite this article

Abstract

The ability of calves persistently infected (PI) with bovine virus diarrhoea virus BVDV to respond immunologically to defined antigens other than BVDV was studied. Five clinically healthy PI calves were studied together with 5 non-PI calves serving as controls. The humoral immune response was tested by measuring the serum antitoxin titre following immunization against tetanus. The cellular immune response was tested by the ability to develop a positive reaction in a cutaneous tuberculin test performed 1 month after immunization against Johne’s disease (paratuberculosis). Finally, a skin-sensitizing agent, dinitrochlorobenzene (DNCB), was employed to study whether PI calves would react by hypersensitization following skin exposure to DNCB for 7 consecutive days followed by application of DNCB to a new skin area remote from the area that had first been exposed.

The response of PI calves to the various types of antigenic stimuli applied was not significantly different from that of the control calves. Thus, PI calves developed a potent antitoxin response after tetanus immunization, they showed a positive reaction to tuberculin skin test after immunization against paratuberculosis, and were skin sentitized with DNCB.

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Acknowledgments

This study was made with support from R. N0rtoft Thomsens Foundation, Viktor A. Goldschmidts Fund and Upjohn’s Jubilee Foundation.

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Authors and Affiliations

  1. Department of Clinical Studies, Division of Large Animal Medicine, The Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870, Frederiksberg C, Denmark

    H. Houe & I. Heron

  2. Department of Bacterial Vaccines, State Serum Institute, Copenhagen, Denmark

    H. Houe & I. Heron

Authors
  1. H. Houe
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  2. I. Heron
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Houe, H., Heron, I. Immune Response to other Agents of Calves Persistently Infected with Bovine Virus Diarrhoea Virus (BVDV). Acta Vet Scand 34, 305–310 (1993). https://doi.org/10.1186/BF03548195

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Acta Veterinaria Scandinavica

ISSN: 1751-0147