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Pathogenicity and Immunity Studies of Haemophilus Parasuis Serotypes

Acta Veterinaria Scandinavica volume 34, pages 193–198 (1993)Cite this article

Abstract

After intranasal inoculation of SPF pigs with the 7 reference strains of Haemophilus parasuis only the reference strains of serotypes 1 and 5 proved to be pathogenic and were able to produce the lesions characteristic of Glässer’s disease. Even though the reference strains of serotypes 2, 3, 4, 6 and 7 proved to be apathogenic, intranasal inoculation resulted in the development of circulating antibodies as demonstrated by the complement fixation test. This serological response suggests an antigenic relationship between serotypes 1 and 3 different from the relationship seen among serotypes 2, 4, 5, 6 and 7. Pigs given an aerosol with the apathogenic serotypes 2, 3, 4 and 7, respectively, resisted challenge with a virulent Danish strain of serotype 5. These results indicate that the 7 serotypes also have antigenic determinants in common and that these determinants elicit cross-protecting immunity on the respiratory mucosa.

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  1. National Veterinary Laboratory, DK-1790, Copenhagen V, Denmark

    R. Nielsen

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  1. R. Nielsen
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Nielsen, R. Pathogenicity and Immunity Studies of Haemophilus Parasuis Serotypes. Acta Vet Scand 34, 193–198 (1993). https://doi.org/10.1186/BF03548209

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  • DOI: https://doi.org/10.1186/BF03548209

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Acta Veterinaria Scandinavica

ISSN: 1751-0147