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Bovine Uterine, Cervical and Ovarian Cytosol Estrogen and Progesterone Receptor Concentrations in Cystic Ovarian Disease

Acta Veterinaria Scandinavica volume 34, pages 35–43 (1993)Cite this article

Abstract

Bovine cytosol estrogen (ERC) and progesterone receptor (PRC) concentrations were measured simultaneously in various regions of the uterus and in ovarian stromal tissue in cows with cystic ovarian disease (follicular cysts), arid the concentrations compared with those in animals with normal cycles. In cystic ovarian disease, ERC concentrations in endometrium (550 fmol/mg cytosol protein (c.p.)) and in myometrium (405) were significantly higher than in control animals. Very high PRC contents were measured in the endometrium (3115) and myometrium (2761) of cows with cystic ovarian disease. In control animals, PRC concentrations in the endometrium and myometrium were significantly lower than in diseased animals. No statistical differences were observed in ERC or PRC contents between the endometrium and the myometrium in cows with cystic ovarian disease. ERC and PRC concentrations in the uterine cervix and ovaries were low compared to those detected in the uterus. Bovine serum estradiol-17ß concentrations were higher (p<0.001) in cows with cystic ovarian disease than in control animals in postpartum anestrus or during the normal estrous cycle. Serum sex hormone-binding globulin (SHBG) concentrations were of the same magnitude as in control cows during their estrous cycles. These findings show that long standing low endogenous progesterone and elevated estradiol concentrations in serum are associated with elevated ERC and PRC concentrations in bovine uterus.

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Acknowledgments

This study was supported by grants from the Research Council for Medicine, and the Research Council for Agriculture and Forestry, of the Academy of Finland, the Oscar Öflund Foundation, the Finnish Veterinary Science Foundation and Coopers Information Center.

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  1. Department of Clinical Chemistry, University of Oulu, Kajaanintie 50, SF-90220, Oulu, Finland

    M. Vesanen

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Vesanen, M. Bovine Uterine, Cervical and Ovarian Cytosol Estrogen and Progesterone Receptor Concentrations in Cystic Ovarian Disease. Acta Vet Scand 34, 35–43 (1993). https://doi.org/10.1186/BF03548221

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  • DOI: https://doi.org/10.1186/BF03548221

Keywords

  • steroid hormones

Acta Veterinaria Scandinavica

ISSN: 1751-0147