Skip to main content
Download PDF

Mesangioproliferative Glomerulonephritis in Mink with Encephalitozoonosis

Acta Veterinaria Scandinavica volume 34, pages 69–76 (1993)Cite this article

Abstract

Renal specimens from 6 mink with encephalitozoonosis were studied by light and electron microscopy and immunohistochemistry. The glomeruli of affected kidneys had a mesangioproliferative glomerulonephritis which was characterized by an increase in mesangial cells and matrix in most glomeruli. Some glomeruli were partially or completely sclerosed. There were protein or granular casts in the cortical and medullary tubules. Interstitial nephritis, vasculitis and tubular cysts were found. Electron microscopy demonstrated extensive matrix and increased cellularity in the mesangial areas. Glomeruli showed segmentally thickened or wrinkled capillary basement membranes. Electron dense deposits were found in the glomerular basement membranes and mesangium. Peroxidase-anti-peroxidase immunohistochemistry demonstrated that IgG and IgM positive material was present as granular deposits in the glomerular basement membrane and occasionally in the mesangium.

References

  • Bjerkàs I: Brain and spinal cord lesions in encephalit-ozoonosis in mink. Acta vet. scand. 1990, 31, 423–432.

    PubMed  PubMed Central  Google Scholar 

  • Bjerkâs I, Nordstoga K, Nicolaissen B, Loftsgaard G: Encephalitozoonosis in mink. 4th Int. Sci. Congr. Fur Anim. Product. Toronto, Canada and Wisconsin, USA, 1988 (poster).

  • Bohman S-O, Olsen S, Petersen VP: Glomerular ultra-structure in extracapillary glomerulonephritis. Acta pathol. microbiol. scand. Sect. A, Suppl. 1974, 249, 29–54.

    Google Scholar 

  • Botha WS, Van Dellen AF, Stewart CG: Canine encephalitozoonosis in South Africa. J.S. Afr. vet. med. Ass. 1979, 50, 135–144.

    CAS  Google Scholar 

  • Botha WS, Stewart CG, Van Dellen AF: Observations on the pathology of experimental encephalitozoonosis in dogs. J.S. Afr. vet. med. Ass. 1986, 57, 17–24.

    CAS  Google Scholar 

  • Cho HJ, Greenfield J: Eradication of Aleutian disease of mink by eliminating positive counterimmunoe-lectrophoresis test reactors. J. clin. Microbiol. 1978, 7, 18–22.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Churg J, Sobin LH: Renal Disease - Classification and Atlas of Glomerular Diseases. Igaku-Shoin, Tokyo-New York 1982.

    Google Scholar 

  • Dore M, Morin M, Gagnon H: Proliferative glomerulonephritis leading to nephrotic syndrome in a cow. Can. vet. J. 1987, 28, 40–41.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Jansen JH: Renal lesions in swine. Thesis., Oslo 1988 pp. 45–73.

    Google Scholar 

  • Kashgarian M: Editorial: Mesangium and glomerular disease. Lab. Invest. 1985, 52, 569–571.

    CAS  PubMed  Google Scholar 

  • Kincaid-Smith P: The Kidney - A Clinico-pathologi-cal Study. Blackwell Scientific Publications, Osney Mead, Oxford 1975, pp. 50–65.

    Google Scholar 

  • Krohn K, Jokelainen PT, Sandholm M: Light and electron microscopic observations on glomerular changes in canine interstitial nephritis. Acta pathol. microbiol. scand. Section A 1973, 81, 461–473.

    CAS  Google Scholar 

  • McCausland IP, Milestone BA: Diffuse mesangioproliferative glomerulonephritis in a horse. N. Z. vet. J. 1976, 24, 241–259.

    Article  Google Scholar 

  • McCully RM, Van Dellen AF, Basson PA, Lawrence J: Observations on the pathology of canine microspor-idiosis. Onderstepoort J. vet. Res. 1978, 45, 75–92.

    CAS  PubMed  Google Scholar 

  • Müller-Peddinghaus R, Kalden JR, Schawbedissen H M zu., Trautwein G, Ueberschär S: Immune complex glomerulonephritis of mink with Aleutian disease. Contr. Nephrol. 1980a, 19, 101–103.

    Article  Google Scholar 

  • Müller-Peddinghaus R, Kalden JR, Schawbedissen HM zu., Trautwein G, Ueberschär S: Correlation of various forms of glomerulonephritis to the amount of serum immune complexes in mink with experimental Aleutian disease. Vet. Pathol. 1980b, 17, 653.

    Article  Google Scholar 

  • Nordstoga K: Nosematosis in blue foxes. Nord. Vet.-Med. 1972, 24, 21–24.

    CAS  PubMed  Google Scholar 

  • Plowright W: An encephalitis-nephritis syndrome in the dog probably due to congenital encephalitozoon infection. J. comp. Pathol. 1952, 62, 83–93.

    Article  CAS  PubMed  Google Scholar 

  • Portis JL, Coe JE: Deposition of IgA in renal glomeruli of mink affected with Aleutian disease. Amer. J. Pathol. 1979, 96, 227–236.

    CAS  Google Scholar 

  • Sabnis SG, Gunson DE, Antonovych TT: Some unusual features of mesangioproliferative glomerulonephritis in horses. Vet. Pathol. 1984, 21, 574–581.

    Article  CAS  PubMed  Google Scholar 

  • Sanford SE: Encephalitozoonosis in a pet rabbit. Can. vet. J. 1987, 28, 417.

    Google Scholar 

  • Shadduck JA, Pokes SP: Encephalitozoonosis (nosematosis) and toxoplasmosis. Amer. J. Pathol. 1971, 64, 657–672.

    CAS  Google Scholar 

  • Shirota K, Yoyama R, Nomura Y: Glomerulopathy in swine: microscopic lesions and IgG or C3 deposition in 100 pigs. Jap. J. vet. Sci. 1986, 48, 15–22.

    Article  CAS  Google Scholar 

  • Slauson DO, Russell SW, Schechter RD: Naturally occurring immunecomplex glomerulonephritis in the cat. J. Pathol. 1971, 103, 131–133.

    Article  CAS  PubMed  Google Scholar 

  • Slauson DO, Lewis RM: Comparative pathology of glomerulonephritis in animals. Vet. Pathol. 1979, 16, 135–164.

    Article  CAS  PubMed  Google Scholar 

  • Testoni FJ: Enzootic renal nosematosis in laboratory rabbits. Aust. vet. J. 1974, 50, 159–163.

    Article  CAS  PubMed  Google Scholar 

  • Van Rensburg IBJ, Du Plessis JL: Nosematosis in a cat: a case report. J. S. Afr. vet. med. Ass. 1971, 42, 327–331.

    Google Scholar 

  • Waller T: The india-ink immunoreaction: a method for the rapid diagnosis of encephalitozoonosis. Lab. Anim. 1977, 11, 93–97.

    Article  CAS  PubMed  Google Scholar 

  • Wilson JM: The biology of Encephalitozoon cunicu-li. Med. Biol. 1979, 57, 84–101.

    CAS  PubMed  Google Scholar 

  • Zhou Z-y, Nordstoga K, Bjerkås I: Extraglomerular lesions in kidneys of mink with encephalitozoonosis. Acta vet. scand. 1992, 33, 33–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

The authors thank Dr. Bent Aasted, Royal Veterinary and Agricultural University, Copenhagen, Denmark, for providing the rabbit anti-mink sera and Dr. Johan Høgset Jansen for valuable suggestions. We thank Birgit Røe, Ingjerd Andersen and Anne Kristine Fevang for skilled technical assistance.

Author information

Authors and Affiliations

  1. Department of Pathology, Norwegian College of Veterinary Medicine, P.O. Box 8146, Dep., N-0033, Oslo 1, Norway

    Z.-Y. Zhou & K. Nordstoga

Authors
  1. Z.-Y. Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. K. Nordstoga
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Zhou, ZY., Nordstoga, K. Mesangioproliferative Glomerulonephritis in Mink with Encephalitozoonosis. Acta Vet Scand 34, 69–76 (1993). https://doi.org/10.1186/BF03548225

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1186/BF03548225

Keywords

  • light and electron microscopy
  • immunohistochemistry

Acta Veterinaria Scandinavica

ISSN: 1751-0147