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Influence of the Local Tolerance on the Pharmokinetics of two Penicillin G Preparations in Cattle and Swine
Inverkan av den lokala toleransen hos två penicillin G beredningar på farmakokinetiken hos svin och nötkreatur
Acta Veterinaria Scandinavica volume 29, pages 199–206 (1988)
Abstract
The addition of citrate buffer to a penicillin G preparation for injection was in a preliminary study found to improve the local tolerance in rabbits. In the present study 2 penicillin G preparations with different citrate buffer content was tested in the target species swine and cattle. The results of the local tolerance studies indicated that the preparation with the highest citrate content caused less tissue damage. In swine this preparation gave 100% higher maximum levels in serum than the more tissue irritating preparation. In calves the most irritating preparation showed significantly longer half-life. The results indicated that the local tolerance may influence the serum levels in a way that may influence the penetration of penicillin.
Sammanfattning
En ökning av innehållet av citratbuffert i en penicillin G beredning för injektion visades i preliminära försök förbättra den lokala toleransen hos kanin. I föreliggande arbete undersöktes effekterna av två penicillin G beredningar med olika citratinnehål hos svin och nötkreatur. Resultaten av toleransstudierna indikerade att en ökad mängd citrat reducerade vävnadsskadorna efter intramuskulär injektion. Hos svin gav den mest vävnadsvänliga beredningen 100% högre maximumkoncentration än den mera vävnadsirriterande. Hos kalv var halveringstiden signifikant längre för den mest vävnadsirriterande beredningen. Resultaten visar att den lokala toleransen efter intramuskulär injektion påverkar farmakokinetiken på ett sätt som kan ha betydelse för penetrationen av penicillin.
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Luthman, J., Dali, V., Jacobsson, S.O. et al. Influence of the Local Tolerance on the Pharmokinetics of two Penicillin G Preparations in Cattle and Swine. Acta Vet Scand 29, 199–206 (1988). https://doi.org/10.1186/BF03548371
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DOI: https://doi.org/10.1186/BF03548371